Term
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Definition
HMG-CoA reductase inhibitors
-statin
pleiotropic effects |
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Term
| Decreased Protein Prenylation |
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Definition
| isoprenoids decrease protein prenylation: leads to reducing arterial intimal thickening, preventing restenosis, increasing iNOS, decrease IL-6 and CRP, decrease platelet aggregation, inhibit PAI --> decrease thrombus formation |
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Term
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Definition
atorvastatin and rosuvastatin have longest half life
all inhibit HMG-CoA to same extent except pravastatin (only 50%) |
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Term
|
Definition
statins reduce LDL
niacin (<exercise) increases HDL
fibric acid decreases TG
problem: niacin causes histamine release |
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Term
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Definition
blocks cholesterol uptake in intestine
can be paired with statin, but does not work |
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Term
|
Definition
treat TG
can be combine with atorvastatin = AtorvaFen
do NOT combine with gemfibrozil |
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Term
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Definition
-LDL: greatest by atorva- and rosuva- but little clinical significance
+HDL: 1%
-TG: 10% |
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Term
|
Definition
DO NOT use during pregnancy
low incidence of ADRs
very safe drugs
some hepatotoxicity and rhabdomyotoxicity
do not take with 3A4 inhibitors (-navirs) |
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Term
|
Definition
dose related
mostly asymptomatic |
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Term
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Definition
-myalgia: soreness
-myopathy: myalgia + high CK
-myolysis: myopathy + myoglobinemia + myoglobinuria |
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Term
|
Definition
-LDL>>-TG>>+HDL
dual acting drugs
single isomers
lipophilic (except prava, rosuva)
atorva and rosuva most potent
cave 3a4 inhibitors and gemfibrozil |
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