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Definition
Unexpected and undesired, results in dangerous effects on the body.
ie. hepatotoxicity
nephrotoxicity
neurotoxicity |
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Term
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Definition
Types of drug effects that are expected when a medication is given at therapeutic doses.
Less serious than adverse effects. |
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| Adverse Event Reporting System (AERS) |
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Definition
| voluntary program that encourages health care providers and consumers to report suspected adverse effects directly to the FDA or the producet manufacturer. |
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Term
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Definition
Highest alert notification FDA can put on a drug
Warns the prescriber that the drug carriers a risk for a serious or even fatal adverse effect. |
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Term
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Definition
| common events, comprising 6% to 10% of all adverse drug effects. All are caused by a hyperresonance of body defenses. |
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Term
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Definition
An adverse drug effect that produces an unusual and unexpected response that is not related to the pharmacologic action of the drug. Vary from patient to patient.
They are not classified as allergies b/c they are not immune related.
No one knows why, they just happen! |
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Definition
| Drugs that cause birth defects |
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Term
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Definition
| occurs when a substance increases or decreases a drug's actions. The substance causing the drug interaction (must be external to the body) may be another drug, a dietary supplement, an herbal product, or a food. |
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Term
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Definition
Two drugs from a similar therapeutic class produce a combined summation response.
Usually used for treating hypertension.
ie. combination of a diuretic: used to lower SBP (10 mmHg) and a beta blocker added to produce another drop of 15 mmHG. Combined drugs produced a drop of 25 mmHg
1 pain med + 2nd pain med = more effective |
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Term
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Definition
The effect of two drugs is greater than would be expected from simply adding the two individual drugs' responses.
Used extensively in treating infections.
1 med makes other med more powerful
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Term
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Definition
| Adding a second drug results in diminished pharmacological response. Results in drug actions being cancelled. |
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Term
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Definition
| Inadvertent adverse effect or complication resulting from medical treatment |
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Term
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Definition
Requires two people to double check the medication:
ie Insulin and warfarin |
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Term
What is grapefruit juices effect on oral medication?
What drugs do they specifically act on? |
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Definition
Grapefruit juice inhibits the enzyme CYP3A4 in the wall of the intestinal tract.
As drugs are absorbed they are NOT inactivated by CYP3A4, and higher amounts then reach the circulation.
Inhibition may last up to 3 days after drinking the juice.
Substances in the juice are called furanocoumarins
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