Term
| Intracellular Receptors the Regulate Gene Expression |
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Definition
- Corticosteroids
- Mineralocorticoids
- Sex Steroids
- Vitamin D
- Thyroid Hormone
- P450 inducers
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Term
| Protein Tyrosine Kinase Signaling |
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Definition
- Insulin
- Epidermal Growth Factor (EGF)
- Platelet-derived Growth Factor
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Term
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Definition
- Nicotinic/Ach --Na+
- GABA(a) -- Chloride
- GABA(a)/Benzodiazepines --Chloride
- GABA(a)/Barbituates -- Chloride
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Term
| Drugs and Receptors the Increase cAMP formation (Gs) |
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Definition
- Epinephrine (β1 and β2)
- Norepinephrine (β1 & β2)
- Isoproterenol (β1 & β2)
- Dopamine (DA1)
- Dobutamine (β1)
- Histamine (H2)
- FSH
Glucagon
- ACTH
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Term
Drugs and Receptors the Inhibit cAMP Formation (Gi)
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Definition
- Norepinephrine (α2)
- Dopamine (D2)
- Clonidine (α2)
- Acetylcholine (α2)
- Morphine (μ, κ, δ)
- Serotonin (5-HT1)
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Term
| Gq-coupled receptors which act through IP3/DAG |
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Definition
- M1 and M3 Muscarinic receptors (ACh)
- α-1 receptors (norepinephrine/ phenylphrine)
- 5-HT1c Receptors (serotonin)
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Term
| Type 1 Drug Induced Hypersensitivy |
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Definition
Anaphylaxis or Immediate
anaphylaxis, uticaria, and angioedema
Mediated by IgE
Caused by Numerous Drugs
Tx: Immediately inject with epinephrine. 0.5mL of 1:1000 solution |
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Term
| Type II Drug Induced Hypersensitivity |
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Definition
Cytotoxic or Autoimmune
Mediated by IgM and IgG that activates complement
Ex) Penicillin hemolytic anemia |
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Term
| Type III Drug Induced Hypersensitivity |
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Definition
Arthus or Immune Complex
Mediated by Ag-Ab Complexes
Serum Sickness
Ex) Sulfonamides, penicillins,thiouracil, iodides, anticonvulsants
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Term
| Type IV Drug Induced Hypersensitivity |
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Definition
Cell Mediated or Delayed
Mediated by Sensitized T-Cells
Often occurs topically
Ex) Poison ivy and many other drugs |
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