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Pharmacology of Fungal Infection
Biochemical and Molecular Principles of Drug Action Biochemical and Molecular Principles of Drug Action
9
Pharmacology
Professional
04/04/2012

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Term
Imidazoles and triazoles
Definition
inhibit 14α-sterol demethylase and thereby prevent the synthesis of ergosterol, which is the principal sterol in fungal membranes.
Term
Fluconazole and voriconazole
Definition
two representative triazoles.
Term
Flucytosine
Definition
inhibits fungal DNA synthesis
Term
Griseofulvin
Definition
inhibits fungal mitosis by disrupting mitotic spindles.
Term
Allylamines, benzylamines, imidazoles, and triinhibit
Definition
inhibit the ergosterol synthesis pathway in the endoplasmic reticulum
Term
Amphotericin B
Definition
is a representative polyene
Term
Echinocandins
Definition
inhibit fungal cell wall synthesis
Term
Flucytosine enters the fungal cell via
Definition
transmembrane cytosine permease
Term
new frontiers in the treatment of Candida and Cryptococcal species, respectively.
Definition
The development of protease inhibitors and phospholipase inhibitors represent
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