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Pharmacology midterm
Lesson 1-5
34
Pharmacology
Undergraduate 3
11/02/2010

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Cards

Term
Which class of drugs can be used to lower blood pressure?
Definition
Adrenergic Blockers, Calcium Channel Blockers, ACE Inhibitors, Angiotensin-Receptor Blockers, and Diuretics.
Term
How does the liver use Vitamin K?
Definition
Vitamin K is used to make 4 clotting factors.
Term
Which class of drugs produces a negative chronotropic effect and a positive inotropic effect?
Definition
Cardiac Glycosides
Term
Define afterload:
Definition
The pressure in the aorta that needs to me overcome for blood to be ejected from the left side of the heart.
Term
What is a chronotropic effect?
Definition
It causes a change in heart rate.
Term
A positive chronotropic effect:
Definition
Increases the heart rate.
Term
A negative chronotropic effect:
Definition
Decreases the heart rate.
Term
Describe the Frank-Starling Law:
Definition
The greater the stretch on myocardial fibers, the greater the force in which they will contract.
Term
What is an inotropic effect?
Definition
A change in the strength or contractility of the heart.
Term
A positive inotropic effect:
Definition
Increases the force of contractions.
Term
A negative inotropic effect:
Definition
Decreases the force of contractions.
Term
Define preload:
Definition
The degree of stretch of cardiac muscle fibers just before they contract.
Term
Define Stroke volume:
Definition
The amount of blood ejected from the ventricles with each beat of the heart.
Term
How do adrenergic blockers lower blood pressure?
Definition
They block the sympathetic nervous system (sympatholytics).
Term
How do calcium channel blockers lower blood pressure?
Definition
They block the channels to prevent Calcium from entering the cell.
Term
How do ACE Inhibitors lower blood pressure?
Definition
They prevent angiotensinconverting enzyme from producing angiotensin II.
Term
How do angiotensin-receptor blockers lower blood pressure?
Definition
They block the action of angiotensin II after it is formed.
Term
How do diuretics lower blood pressure?
Definition
They increase excretion of water and electrolytes, and block reabsorption of sodium and chloride.
Term
Name 4 Calcium Channel Blockers:
Definition
Amlodipine, verapamil, nifedipine, and diltiazem.
Term
What drug class are warfarin and heparain in?
Definition
Anticoagulant Agents
Term
Metoprolol and Propanolol are in what drug class?
Definition
Adrenergic Blockers: metoprolol is a Beta 1 Selective blocker and propanolol is a non-selective beta blocker.
Term
Name a Thrombolytic.
Definition
Streptokinase
Term
Name two hydantoins.
Definition
Phenytoin and Carbamazepine.
Term
Hydantoins are used for:
Definition
Seizure Treatment
Term
Triptans are used for:
Definition
Migraine Treatment
Term
Which drug is used for conscious sedation and to control status epilepticus?
Definition
Midazolam
Term
Acetaminophen belongs to which drug class?
Definition
nonopoid analgesic and antipyretic
Term
What are the main adverse effects of aspirin and other non-selective COX inhibitors?
Definition
Bleeding, Bruising, and upset stomach.
Term
What are the possible adverse effects for acetaminophen?
Definition
Liver damage in excess.
Term
What are the potential adverse effects for COX2 Inhibitors?
Definition
Myocardial infarction, liver failure.
Term
What are the potential adverse effects for opoids?
Definition
Sedation and respiratory depression, decreased GI motility, decreased cough reflex, dependency, euphoria.
Term
What are the potential adverse effects for general anesthetics?
Definition
heart failure, lung irritation, coughing, mucus secretion, laryngospasm, nausea, decreased GI motility, liver damage
Term
How do opoids work?
Definition
They inhibit the release of substance P (a neurotransmitter) to decrease transmission of pain messages from the peripheral nerves to the spinal nerves.
Term
How do NSAIDs work?
Definition
They inhibit the enzyme involved in prostaglandin formation, COX.
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