Term
| Acts on inducing Antithrombin III |
|
Definition
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|
Term
| Heparin induced thrombocytopenia |
|
Definition
|
|
Term
| Reversal agent for Heparin |
|
Definition
Protamine Sulfate
Positively charged molecule that acts by binding the negatively charged heparin |
|
|
Term
| Low Molecular based heparin |
|
Definition
Enoxaparin
Act more on factor Xa, have better bioavailability and 2-4 times longer half life. Better manageable because it's longer half life and based on patient's weight.
Remember heparin and LMWH are not the same. Have different kinetics |
|
|
Term
| Drug that inhibits Epoxide Reductase |
|
Definition
Warfarin
Stops vitamin K dependent factors II, VII, IX, X and Protein C and S. Protein C and S affected first (can lead to skin necrosis.
TARETOGENIC because it can cross the placenta |
|
|
Term
|
Definition
tPA (alteplase)
Urokinase
Streptokinase
APSAC
Act on directly aiding conversion of plasminogen to plasmin
Contraindicated in patients with active bleeding, recent surgery, or bleeding diseases |
|
|
Term
| Drugs to reverse Warfarin |
|
Definition
Vitamin K (oral or IV)
Fresh Frozen Plasma |
|
|
Term
| Drug to reverse thrombolytics (tPA) |
|
Definition
|
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