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Pharmacology Gastrointestinal System Agents
For NPhT Exam
51
Pharmacology
Not Applicable
05/08/2012

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Cards

Term
Most common disease of GI tract are?
Definition
Acid reflux, Ulcers, Nausea/vomiting, Diarrhea, Constipation
Term
6 main groups of GI meds
Definition
Acid Reducers, Antidiarrheals, Laxatives, GI Stimulants, Antiemetics, Antiflatulents
Term
Acid Reducers
Definition
Treats acid reflux, mild cases called heartburn (damage to esophagus known as GERD or gastroesophageal reflux disease). Divided into antacids, H-2 blockers, and PPI's.
Term
Antacids
Definition
Subclass of acid reducers. Neutralize gastric acid. Most components are bases (calcium/magnesium/aluminum hydroxide). Hard on bad kidneys. Quick acting.
Term
Drug interactions with antacids
Definition
Antacids have ingredients that can bind up tetracyclines and fluoroquinolone antibodies, such as in Biaxin.
Term
Maalox Regular tabs ingredients and class
Definition
Contain calcium carbonate and is an antacid
Term
Maalox Regular liquid ingredients and class
Definition
Contain aluminum and magnesium hydroxide and simethicone.
Term
Brand: Tums E-X. Generic and class?
Definition
Calcium carbonate, an antacid. Brand?
Term
Brand: Rolaids, Mylanta ultra. Generic and class?
Definition
Calcium carbonate and magnesium hydroxide, an antacid. Brand?
Term
H-2 Receptor Antagonist
Definition
Acid reducer subclass. A.k.a. H-2 blockers. Works by supressing cells in stomach that produce acid. Most popular meds are Ranitidine (Zantac) and Famotidine (Pipcid). Takes awhile to take effect, but lasts long. Commonly end in "tidine"
Term
Brand: Zantac. Generic and class?
Definition
Ranitidine, a H-2 receptor antagonist (acid reducer). Brand?
Term
Brand: Pepcid. Generic and class?
Definition
Famotidine, a H-2 receptor antagonist (acid reducer). Brand?
Term
Proton Pump Inhibitors (PPI)
Definition
Acid reducer subclass. Acts on acid pumps in stomach to prevent acid production. Popular meds are Omeprazole (Prilosec) and Pantoprazole (Protonix). Commonly end in "prazole"
Term
Brand: Prilosec. Generic and class?
Definition
Omeprazole, a Proton Pump inhibitor (acid reducer). Brand?
Term
Brand: Protonix. Generic and class?
Definition
Pantoprazole, a Proton Pump inhibitor (acid reducer). Brand?
Term
Brand: Nexium. Generic and class?
Definition
Esomeprazole, a Proton Pump inhibitor (acid reducer). Brand?
Term
Brand: Prevacid. Generic and class?
Definition
Lansoprazole, a Proton Pump inhibitor (acid reducer). Brand?
Term
Brand: AcipHex. Generic and class?
Definition
Rabeprazole, a Proton Pump inhibitor (acid reducer). Brand?
Term
Brand: Dexilant. Generic and class?
Definition
Dexlansoprazole, a Proton Pump inhibitor (acid reducer). Brand?
Term
Antidiarrheals
Definition
Major GI med class. Slows movement of intestines to absorb excess water and decrease stool frequency. Common meds are Loperamide (Imodium) and Lomotil (diphenoxylate and atropine)
Term
Bismuth Subsalicylate
Definition
Has antacid and antidiarrheal qualities. Should be avoided with patients on aspirin/allergic to aspirin/on tetracyclines and fluoroquinolones, kids with fever,
Term
Brand: Lomotil. Generic and class?
Definition
Diphenoxylate with atropine (added to prevent abuse), an antidiarrheal. Brand?
Term
Brand: Imodium AD. Generic and class?
Definition
Loperamide, an antidiarrheal. Brand?
Term
Brand: Pepto-Bismol. Generic and class?
Definition
Bismuth subsalicylate, an antacid and antidiarrheal.
Term
Laxatives
Definition
Major GI med class. Treats constipation, which is the difficult passage of dry, hard stools. 6 classes
Term
Bulk-forming laxatives
Definition
Subclass of laxatives. Mimic body's natural response. Commonly contain fiber. Given 2 hours before/after tetracyclines and digoxin
Term
Emollient Laxatives
Definition
Laxative subclass. A.k.a. "stool softeners". Allow more water to be absorbed by stool. Common med is Docusate
Term
Docusate
Definition
Most common Emollient laxative. 2 forms: Sodium (Colace) and Calcium (Kaopectate liqui-gel)
Term
Saline Laxatives
Definition
Laxative subclass. Slow down colon transit time. Meds commonly contain magnesium, which can't be taken by patients with bad kidneys.
Term
Hyperosmotic Laxatives
Definition
Laxative subclass. Increased fluid in intestinal lining. Common meds are Lactulose and polyethylene glycol.
Term
Lactulose (Kristalose)
Definition
Used for chronic constipation cases
Term
Polyethylene Glycol
Definition
Used for colonoscopies/diagnostic procedures to clean out the gut. Common med is called MiraLAX
Term
Stimulant Laxative
Definition
Laxative subclass. Stimulate intestines to promote motility. Work within 6 hours. Most common med is bisacodyl (Dulcolax). Should only be used as "rescue" treatment when all else has failed.
Term
Chloride-channel Activiators.
Definition
Subclass of laxatives. New class. Enhances chloride channels in intestine leading to increased fluid secretion. For chronic constipation or IBS-C
Term
Brand: Amitiza. Generic and class?
Definition
Lubiprostone, the only chloride-channel activator on the market at the time. Brand?
Term
Brand: Metamucil. Generic and class?
Definition
Psyllium, a bulk forming laxative. Brand?
Term
Brand: Colace. Generic and class?
Definition
Docusate sodium/clacium, a stool softener (laxative). Brand?
Term
Brand: Kristalose. Generic and class?
Definition
Lactulose, a hyperosmotic laxative. Brand?
Term
Brand: MiraLAX. Generic and class?
Definition
Polyethylene glycol, a hyperosmotic laxative. Brand?
Term
Brand: Dulcolax. Generic and class?
Definition
Bisacodyl, a stimulant laxative. Brand?
Term
Brand: Amitiza. Generic and class?
Definition
Lubiprostone, a chloride channel activator (laxative). Brand?
Term
GI Stimulants
Definition
Major GI med class. Used for when movement of food out of stomach is slow. Most common med is metoclopramide (Reglan). Can cuase irreversible movement disorder "tardive dyskinesia"
Term
Brand: Reglan. Generic and class?
Definition
Metoclopramide, a GI stimulant (laxative). Brand?
Term
Antiemetics
Definition
Major GI med class. Treats nausea. Common meds are promethazine (Phenergan) or prochlorperazine (Compazine). Causes "anticholinergic" side effects. Come in suppositories.
Term
Serotonin-Receptor Antagonists
Definition
Type of antiemetic. Used in cancer and some pregnant patients. Decreases serotonin hormone that causes nausea stimulation in brain. Common med is Ondansetron (Zofran). Commonly end with "setron"
Term
Brand: Phenergan. Generic and class?
Definition
Promethazine, an antiemetic with antihistamine properties (laxative). Brand?
Term
Brand: Compazine. Generic and class?
Definition
Prochlorperazine, an antiemetic (laxative). Brand?
Term
Brand: Zofran (ODT). Generic and class?
Definition
Ondansetron, an serotonin receptor antagonist antiemetic (laxative). Brand?
Term
Antiflatulents
Definition
Major GI med class. Break up and reduce size of gas bubbles. Common med is simethicone (Gas-X)
Term
Simethicone (Gas-X)
Definition
Antiflatulent. Added to antacids or H-2 blockers. Few side effects, several dosage forms, and can be used in infants.
Term
Brand: Gas-X. Generic and class?
Definition
Simethicone, an antiflatulent (laxative)
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