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Pharmacology final-Baker U pt 2
non-matching section
25
Nursing
Undergraduate 3
05/11/2011

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Cards

Term
Qualities of a perfect drug
Definition
Effectiveness, safety, selectivity
Term
non-proprietary name of drug, assigned by US names council
Definition
Generic name
Term
description of drug using nomenclature of chemistry
Definition
chemical name
Term
drug movement through the body
Definition
pharmacokinetics
Term
movement from site of entry to bloodstream
Definition
absorption
Term
movement of drugs throughout the body
Definition
distribution
Term
the method by which drugs are inactivated or biotransformed by the body
Definition
metabolism
Term
the study of the influence of genes on individual response to drugs
Definition
pharmacogenetics
Term
rate of metabolism is decreased in what kind of patients
Definition
infants (immature hepatic enzyme)
pt c liver or cardiac disease
pt on low-protein diets
Term
time required for the serum concentration of a drug to decrease by 50%
Definition
serum half-life
Term
what drugs do to the body et how they do it
Definition
Pharmacodynamics
Term
largest effect that a drug can produce
Definition
Efficacy
Term
amount of drug we must give to elicit effect
Definition
potency
Term
Morphine mechanism of action, metabolism, excretion, side effects
Definition
inhibits the release of substance P
metabolized by liver
excreted by kidneys
respiratory depression, N/V, hypotension, sedation, constipation, urinary retention, Increased ICP
Term
First choice for severe pain, why
Definition
Morphine- no ceiling, half-life 15-30hrs
Term
antidote for opioid drugs
Definition
Narcan (naloxone)
Term
Mechanism of action for Narcotic antagonists
Definition
competes with opioids for receptor site, displaces opioids already occupying site. May cause withdrawl symptoms in opiate dependent ppl
Term
Prototype of analgesic-antipyretic, anti-inflammatory drug
Definition
Aspirin (acetylsalicytic acid)
Term
mech of action aspirin
Definition
inactivation of cox-1 and cox-2; inhibits formation of prostaglandins. IRREVERSIBLY inhibits platelet Cox-1
Term
ASA side effects
Definition
Salicylism: tinnitus (ringing of ears), HA, dizziness, sweating. Reye's syndrome (fatal in children)
Term
Prototype of NSAIDS, mech of action
Definition
Ibuprofen: reversible inihibition of cox-1 and cox-2; anti-inflammatory, analgesic, and antipyretic properties. Antiplatelet only exist when drug is present in blood.
Term
Use of NSAIDS
Definition
mild-moderate pain/inflammation of musculoskeletal disorders, OA, RA, bursitis, gout
Term
mechanism of action acetaminophen
Definition
inhibition of synthesis in CNS only, no anti-inflammatory action. Metabolized by liver: do not mix with alcohol.
Term
antidote for tylenol
Definition
acetylcysteine (mucomyst)
Term
Adrenergic prototype, mech of action
Definition
epinephrine, stimulates adrenergic receptors on cell membranes
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