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Pharmacology Exam 5: Alternative Medicine
alternative medicine
86
Pharmacology
Graduate
04/27/2011

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Cards

Term
vitamin/mineral drug list:
Definition
- vit. A, B, C, D, E, K
- tretinoin
- calcium
- ascorbic acid
- nicotinamide
- nicotinic acid
- folic acid
- cyanocobalamin
Term
Herbal drug list:
Definition
- melatonin
- ma-huang
- St. John's wort
- ginkgo
- ginseng
- saw palmetto
- dehydroepiandrosterone
Term
Toxicology drug list:
Definition
carbon monoxide, amphetamines, marijuana, LSD, caustic agents (acids & bases), morphine, meperidine, atropine, barbiturates, benzodiazepines, ethanol, methanol, neuroleptics (phenothiazines), kerosene, organophosphates, salicylates, acetaminophen, cocaine, PCP, tricyclic antidepressants, methaqualone, digoxin, phenytoin, theophylline, cyanide, heavy metals (e.g. arsenic, iron, lead, copper, mercury), oxalate
Term
Antidote drug list:
Definition
: ipecac, charcoal, n-acetylcysteine, BAL (dimercaprol), flumazenil, glucagons, hyperbaric oxygen, vitamin K, nitrites, digoxin-specific Fab fragments, ethanol, fomepizole, protamine, deferoxamine, pyridoxine, naloxone, methylene blue, atropine, pralidoxime, hemodialysis, hemoperfusion, alkaline diuresis
Term
water soluble vitamins:
Definition
- Vit. C (ascorbic acid)
- Nicotinic acid and nicotinamide (derivatives of vitamin B3)
- folic acid
- cyanocobalamin (vit. B12)
Term
Lipid soluble vitamins:
Definition
A, D, E, K
Term
Vitamin C (ascorbic acid) is necessary in body to form what?
Definition
- collagen in bones, cartilage, muscle, and blood vessels
Term
Deficiency of vitamin C:
Definition
scurvy
Term
Overdose of Vitamin C:
Definition
greater than 2,000mg/day
Term
Nicotinic acid and nicotinamide are ___ __ __.
Definition
vitamin B3 derivatives
Term
Deficiency of vitamin B3 (nicotinic acid/nicotinamide):
Definition
- Pellegra: skin disease, diarrhea, dementia, depression
Term
Overdose of vitamin B3 (nicotinic acid/nicotinamide):
Definition
- liver toxicity
- increased liver enzyme levels in blood
- jaundice
- ascites
- liver failure
Term
Folic acid (form of vitamin B)deficiency:
Definition
- risk of fetus developing neural tube defects (spina bifida)
- Megaloblastic and Macrocytic anemias
Term
Folic acid overdose:
Definition
- very high doses> CNS side effects
Term
Cyanocobalamin is vitamin ___.
Definition
B12
Term
Cyanocobalamin (vit B12) deficiency helps maintain healthy __ __, __ __ __, and is also needed to make ___.
Definition
- nerve cells
- red blood cells
- DNA
Term
Deficiency of cyanocobalamin (vit B12):
Definition
Pernicious anemia
Term
Vitamin A is required for many biological procedures like __ and __ __.
Definition
vision and cellular growth
Term
Vitamin A deficiency:
Definition
- xeropthalmia (dry eye)
- night blindness
- total blindness
- skin disorders
Term
Vitamin A uses:
Definition
- acne
- certain leukemias
- measles
- malaria
- retiniis pigmentosa
Term
Vitamin A overdose:
Definition
- hypervitaminosis A
- infants with acute toxicity have bulging fontanels
- adults get brain tumor like symptoms
- severe toxicity: eye damage, high calcium levels, liver damage
Term
Vitamin D aids in absorption of ___, helping to from and maintain strong bones.
Definition
- calcium
Term
Vitamin D deficiency:
Definition
- rickets in children
- osteomalacia in adults
Term
Vitamin D uses:
Definition
Vitamin D is used for TREATMENT OF:
- hypophosphatemia
- hypocalcemia
- hyperparathyroidism
- psoriasis
- osteomalacia
- renal osteodystrophy
Term
Vitamin D overdose:
Definition
- hypercalcemia
- excess bone loss
Term
Vitamin E acts as an ___, acts through ___, and has an __ __.
Definition
- antioxidant
- immunomodulation
- antiplatelet effect
Term
Vitamin E deficiency:
Definition
- profoundly effects CNS> ataxia and peripheral neuropathy
Term
Vitamin E uses are controversial
Definition
Term
Vitamin E overdose:
Definition
increase risk of bleeding problems
Term
Vitamin K is necessary for __ __.
Definition
normal clotting
Term
Vitamin K deficiency:
Definition
- defective blood clotting
- increased bleeding
Term
Vitamin K uses:
Definition
Vitamin K used for treatment of:
- hemorrhagic disease of newborn
- warfarin reversal
Term
NCCAM: branch of FDA, look at literature out there and determine if they are good studies and if the herbals are good to use or not.
Definition
Term
Black cohosh claimed uses:
Definition
- hot flashes
- night sweats
- vaginal dryness
- other menopause symptoms

STUDIES ARE MIXED AND LESS THAN 6 MONTHS LONG
Term
Black cohosh side effects:
Definition
- HA
- gastric complaints
- weight problems
- no reports of interactions with prescriptions
Term
Contraindication for black cohosh:
Definition
- patient at risk for breast cancer should not take black cohosh
Term
Chasteberry uses:
Definition
- Monks in Middle Ages used it to decrease sexual desire
- PMS
- menopausal symptoms
- infertility
- acne

DATA SHOWS SOME BENEFIT FOR USE IN PMS, BREAST PAIN, AND INFERTILITY IN POORLY DESIGNED STUDIES. MORE DATA NEEDED.
Term
OBGYNS use ___ to treat infertility and PMS symptoms. But be careful b/c it interacts with __ __ and other hormones.
Definition
- chasteberry
- birth control pills
Term
Echinacea uses:
Definition
- common colds
- flu
- URIs

NO STUDY HAS SHOWN ANY EVIDENCE OF IT WORKING THOUGH MORE RESEARCH IS UNDERWAY REGARDING EFFECTIVENESS IN URI.
Term
Echinacea side effects:
Definition
- asthma
- anaphylaxis
- rashes
Term
___ is related to plants in the daisy family including ragweed. So people with allergies should be careful.
Definition
Echinacea
Term
Ephedra aka __ __ or ___ ___.
Definition
Chinese ephedra
ma huang
Term
Ephedra uses:
Definition
- weight loss
- colds
- fever
- flu
- headaches
- asthma
- wheezing
- nasal congestion
Term
Ephedra increases risk of __, __, and ___ problems, as well as __ __ __ and __.
Definition
- heart, psychiatric, and gastrointestinal problems
- high blood pressure and stroke
Term
Ephedra side effects:
Definition
nausea, anxiety, headache, psychosis, kidney stones, tremors, dry mouth, irregular heart rhythms, heart damage, high blood pressure, restlessness, sleep problems, irritation of the stomach, and increased urination

NO LONGER FDA APPROVED AS OF 2004
Term
With fiber/flax seed the benefits outweigh the risks.
Definition
Term
Flax seed. Take 1 tablespoon per day. This is the largest source __, largest source of ___ __, and largest source of __ __.
Definition
- fiber
- omega 3s
- plant estrogen
Term
Data on flax and fiber show that it is an effective __. There is mixed data on it lowering ___ and preventing __ __. No side effects.
Definition
- effective laxative
- lowering cholesterol and preventing heart disease
Term
1 tablespoon flax seed= 9 grams fiber
Definition
Term
Flax has omega 3 in form of ___ while fish oil has omega 3 in form of ___.
Definition
ALA
DHA
Term
Garlic uses:
Definition
- tmt of high cholesterol
- tmt of hypertension
- heart disease
- stomach cancer

DATA SHOWS THAT IT DOES NOT WORK
Term
Garlic side effects:
Definition
breath and body odor, heartburn, upset stomach, and allergic reactions, acts like a blood thinner similar to ASA, interferes with some anti-HIV meds
Term
Garlic acts like a ___ __ like ASA, so it needs to be stopped before surgery. It also interferes with __ meds.
Definition
- blood thinner
- HIV
Term
Ginger uses:
Definition
- stomach aches
- nausea
- diarrhea

safely relieve pregnancy-related nausea and vomiting; studies are mixed on effect on chemo-induced nausea
Term
ginger side effects:
Definition
- few if any
Term
Ginko Biloba uses:
Definition
- improve memory
- prevent Alzheimer's disease and other dementia
- may also reduce symptoms of claudication

studies are promising but more needed
Term
Ginko Biloba side effects:
Definition
Term
Ginseng use:
Definition
- boost immune system
- improves mental and physical performance
- tmt of erectile dysfunction
- menopause symptoms
- lower blood glucose

Data shows it may be effective at lowering blood glucose, but no data for other claims.
Term
Ginseng side effects:
Definition
- headaches
- sleep problems
- GI problems
- caution in patients with Diabetes
Term
Glucosamine use:
Definition
- osteoarthritis tmt

good evidence to support the use of glucosamine sulfate in the treatment of mild-to-moderate knee osteoarthritis
Term
Glucosamine side effects:
Definition
- upset stomach
- drowsiness
- insomnia
- headache
- skin reactions
- sun sensitivity
- nail toughening
- may increase bleeding risk
Term
Kava (aka kava pepper) uses:
Definition
- anxiety
- insomnia
- menopausal symptoms

Some evidence shows may be effecive against anxiety, but FDA warns it can cause liver toxicity
Term
What herb is supposed to help with anxiety but may cause liver toxicity?
Definition
Kava
Term
Kava side effects:
Definition
- liver damage/hepatitis/liver failure
- dystonia
- may interact with Parkinson's drugs
Term
what herb used to treat anxiety may interact with Parkinson's drugs:
Definition
Kava
Term
Noni is aka ___, __ __, __ __, and __ __.
Definition
- Morinda
- Indian mulberry
- Hog apple
- Canary wood
Term
Noni uses:
Definition
- joint pain
- skin conditions
- cardiovascular disease
- diabetes

Data has shown antioxidant, immune-stimulating, and tumor-fighting properties, but not well studied;
Term
Noni side effects:
Definition
- high potassium (so not good for patients with liver disease)
- liver disease
Term
Noni CI:
Definition
kidney disease b/c causes high potassium
Term
ALA omega 3s are in __, __,__, and __ __.
Definition
flax
soy
walnuts
vegetable oils
Term
EPA and DHA omega 3s are in __ and __.
Definition
fish and nuts
Term
In pregnancy you need ____ by third trimester to help brain development.
Definition
200-300 IU
Term
Omega 3 uses:
Definition
- lower TGs
- reduce risk of death
- reduce risk of heart attack
- used to treat abnormal heart rhythms
- reduce risk of stroke
- lowers blood pressure slightly
Term
omega 3 side effects:
Definition
- fishy taste
- increased bleeding at high doses
- potentially harmful contaminants such as dioxins, methylmercury, and polychlorinated biphenyls (PCBs) are found in some species of fish
Term
Primrose oil uses:
Definition
- PMS
- menopausal symptoms
- eczema

data not very supportive
Term
side effects of primrose oil:
Definition
headache
GI problems
Term
Red rice yeast is aka ___. One of these __ __ is a potent inhibitor of ___ ___ __ and is aka __ or ___.
Definition
- Monacolins
- Monacolin K
- HMG-CoA reductase
- Mevinolin
- Lovastatin
Term
Red rice yeast use:
Definition
- cholesterol lowering agent

supportive evidence for TG lowering and LDL lowering properties; no strong evidence exists for cardiovascular benefits or diabetes
Term
Side effects of Red Rice Yeast:
Definition
similar to those for the prescription drug lovastatin (MevacorĀ®) heartburn, gas, bloating, muscle pain or damage, dizziness, asthma, and kidney problems are possible; people with liver disease should not use red yeast products; may increase the risk of bleeding.
Warning
Term
Red rice yeast is a precursor to the __ drugs.
Definition
statin
Term
Saw Palmetto aka __ __ __ __ aka __ __.
Definition
- American dwarf palm tree
- Cabbage palm
Term
Saw palmetto uses:
Definition
- urinary symptoms associated with enlarged prostate
- chronic pelvic pain
- bladder disorders
- decreased sex drive
- hair loss
- hormone imbalances

not enough scientific evidence to support the use of saw palmetto for reducing the size of an enlarged prostate or for any other conditions
Term
Saw palmetto side effects:
Definition
- stomach discomfort
- tender breasts
- decreased libido
Term
St. John's Wort uses:
Definition
- depression
- anxiety
- sleep disorders

some effect shown compared to placebo in mild depressive disorder but more well-developed studies are needed and there are safety concerns
Term
St Johns Wort interacts with __ __ __.
Definition
oral contraceptive pills
Term
St. John's wort side effects:
Definition
- increased sensitivity to sunlight
- anxiety
- dry mouth
- dizziness
- GI symptoms
- fatigue
- headache
- sexual dysfunction
- tons of drug interactions including birth control
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