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Pharmacology Chapter 16
NWTC Chapter 16
30
Pharmacology
Undergraduate 2
03/23/2010

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Term
GI Drugs
Definition
antacids
ulcer
antispasmodics
IBS
antidiarrhea
antiflatulent
laxatives and cathartics
antiemetics
Term
antacids
Definition
neurtralize hydrochloric acid
indigestion, heartburn sour stomach
relieve pain and promote healing of gastic and duodenal ulcers between meals and at night
esophageal reflux
Term
antacid ingredients
Definition
aluminum
calcium carbonate
magnesium
usu sodium
Term
sodium bicarbonate
Definition
not recommended alone becasue of flatulence, metabolic alkalosis, electrolyte imbalance
Term
calcium carbonate
Definition
`Tums, constipation
Term
most common antacids
Definition
magnesium, can cause diarrhea
aluminum can cause constipation
combinations better, Maalox, Gelusil, Mylanta
Term
antacid side effects
Definition
constipation
diarrhea
urinary calculi and renal complic
Term
antacid contraindication
Definition
CHF
renal, hx calculi
cirrhosis, edema
dehyd, elect imbal
Term
ulcer and gastroesophageal reflux meds
Definition
cimetidine/Tagamet
famotidine/Pepcid
ranitidine/Zantac
reduce gastric acid secretion , acting as a histamine blocker
GERD, upper GI bleeding, esophagitis
long term use can deplete instrinsic factor needed for B12
Term
anti ulcer medication contraindications
Definition
liver, renal
children, preg, lac
Term
Tagamet interactions
Definition
may occur with coumadin, also Zantac
phenytoin
propranolol
diazepam
lido caine
theophylline, Zantac, too
tricyclics
antacids can block absorp.
Term
Pepcid
Definition
fewer interactions than other anti ulcer
Term
misoprostol/Cytotec
Definition
synthetic analog of prostaglandin E1 inhibits gastric acid secretion
protects mucosa from nsaids, esp older and hx gastric ulcers
Term
misoprostol/Cytotec SE, contraind., interactions
Definition
diarrhea, N, abdominal pain, take with food
spontaneous abortion, maternal/fetal death
contra: women of childbearing, preg, children under 12
Term
Proton Pump Inhibitors
Definition
omeprazole/Prilosec
short term, GERD, confirmed gast/duod ulcer, erosive esophagitis, heartburn
lansoprazole/Prevacid
raveprazole/Aciphex
pantoprazole/Protonix
esomeprazole/Nexium
gastric antisecretory agent
Term
PPI SE, interactions
Definition
diarrhea, constipation, NV, abd pain
HA, dizziness
inter: H2 blockers, decrease effect
sucralfate, delays absorb
diazepam, pheytoin, warfarin
ampicillin, ketoconazole, iron
no food
Term
sucralfate/Carafate
Definition
inhibitor of pepsin, makes paste with hydrochloric acid
empty stomach
SE: constipation, rare
INT: absorption, 2 hours between
antacids decrease effectiveness
Term
Helidac pack
Definition
treating H. pylori, tetracycline, metronidazone, bsmuth salicylate
Term
Prevpac
Definition
amoxicillin, clarithromycin, lansoprazole/Prevacid
h pylori
Term
antispasmotics, anticholinergic
Definition
peptic ulcers
hypermotility,
colic
preop, control saliv and secre.
antimuscarinic
decrease motility
Term
hycoscyamine/Cystospz
Levsin
Levsinex
Definition
anticholinergic/antimuscarinic
peptic ulcer, hypermotility
Term
hyoscyamine SE, contra, inter
Definition
Dry mouth, constipation
blurred vision, dizziness, drowsiness
urinary retention
confusion - older
contra: glaucoma
CV
GI, ulcer colitis
BPH, bladder obstruc
myasth gravis
preg/lac
inter: phenothiazines, decreased effects, increased antichol\
tricyclic
opinate agonists
Term
salicylates
Definition
inflammatory bowel disease
sim to aspirin, antiflamm GI tract
Crohns, ulcerative colitis
Term
salicylates,
Definition
mesalamine/Asacol
sulfasalazine/Azulfidine
safe long term
Term
salicylate SE, Contra, inter
Definition
anorexia, NV, diarr, abd cramps
HA, weakness, dizziness
caution: allergy to salicylates
allergy to sulfonamides with sulfasalzine
allergy to sulfites (Rowasa enema)
inter: warfarin, methotrexate, cyclosporine
oral diabetic
NV
Term
antidiarrhea
Definition
kaolin and pection/Kapectolin, absorb and protect, dry
SE constipation
inter: digoxin, impaired abso
no infants, no bower obstru
2 hours before, after meds
Term
diphenoxylate with atropine/Lomotil
loperamine/Imodium
Definition
slow motility
Term
diphenoxylate with atropine/Lomotil
loperamide/Imodium SE, contra
Definition
lomotil: anticholinergic, drying, blurred vision, urinary retent, lethargy, confusion, flushing
Lomotil, Imodium: abd disten, NV
contra: diarrhea infection or poisoning
preg, young chldren
colitis from antibiotics
ulcertive colitis
cirrhosis
Term
lactobacillus Acidophilus/Lactinex
Definition
acid producing bacterium in cultre
diarr caused by antibiotics, infec, irrit colon, colostomy, amebiasis
Term
lactobacillus acidophilus/Lactinex contra:
Definition
high fever
sensitivity to milk
long term
prosthetic heart
avoid: cabbage, onions, beans
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