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Pharmacology Chapter 13
NWTC Chapter 13
39
Pharmacology
Undergraduate 2
03/15/2010

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Term
Adrenergics/Sympathomimetic
Definition
Mimic action of sympathetic nervous systom
Term
Actions of adrenergics
Definition
Cardiac stimulation
Increased blood flow to skel. musc
peripherial vasoconstriction
bronchodilation
mydriatic dilation of pupils
Term
Adrenergic uses
Definition
restore rhythm in cardiac arrest
elevate bp in shock
constrict capillaries topically
dilate bronchioles in asthma, bronchospasm, and anaphylactic
opthalmic proc
Term
Adrenergic side effects
Definition
Palpitations
nervousness/tremors
tachycardia
cardiac arrythmias
hypertension
hyperglycemia
Term
Adrenergic cautions
Definition
Angina
coronary insufficiency
hypertension
cardiac arrhythmias
angle closure glau
organic brain damage
hyperthyroidism
dosage
Term
Adrenergic interactions
Definition
beta blockers
alpha blockers
MAOI
CNS drugs
Term
Adrenergics
Definition
Epinephrine/Adrenalin
Ephedrin/Ephedrine
Dopamine/Intropin
Isoproterenol/Isuprel
Metaraminol/Aramine
Norephinephrine/Levophed
Term
epinephrine/Adrenalin
Definition
CAUTION WITH DOSAGE
0.1-0.5 ml SQ, IM delt, 1:1000
5-10 mlIV, 1:10,000
Bronchospasm, asthma, cardiac arrest, anaphylaxis
Term
ephedrine/Ephedrine
Definition
25-50mg IM, SQ
raise BP
Term
dopamine/Intropin
Definition
2-5 mcg/kg/min IV
raise BP
cardiotonic
Term
isoproterenol/Isuprel
Definition
10-15 mg SL 6-8 hrs, or inhalation 4X/day
0.02 - 0.2mg IV, IM
asthma, bronchospasm
heartblock or ventricular arrythmias
Term
metaraminol/Aramine
Definition
0.5-5mg IV
raise BP in shock
Term
norepinephrine/Levophed
Definition
2-4 mcg/min IV
Severe shock
Term
Adrenergic Blockers/Beta Blockers
Definition
Propranolol/Inderal
block the action of the sympathetic nervous system
Term
Adrenergic Blocker uses
Definition
Hypertension
Cardiac arrythmias
Angina pectoris
Migraine headaches
Term
Adrenergic blocker side effects
Definition
Hypotension
Bradycardia
Fatigue
Confusion
Term
Adrenergic blocker cautions and contraindications
Definition
CHF, AV block
Hypotension
Asthma
Diabetes
Term
Adrenergic blocker interactions
Definition
Digitalis
Insulin/oral
theophylline
Alcohol
MAOI & Tricyclics
Epinephrine
Term
Adrenergic blocker
Definition
propranolol/Inderal
160-480mg/day divided
angina: 10-20mg, qid
arrhythimias: 10-30mg qid
IV 1-3 mg CAUTION
migraine: 80mg initial to 160-240 divided
Term
Cholinergic actions
Definition
mimic parasympathetic, liberate acetylcholine
increase peristalsis
increase contractions bladder
increase secretions
increase skeletal muscle strenght
lower intraocular pressure
constrict pupils
slow heart
Term
Cholinergic uses
Definition
bethanechol: nonobstructive urinary retention
neostigmine: abdominal distention
neostigmine: myastenia gravis
pilocarpine: open angle glaucoma
Term
Cholinergic side effects
Definition
NV, diarr
muscle cramps and weakness
hypotension, slowing heart
sweating, salivation, lacrimation, flushing
respriatory depression, bronchospasm
Term
Cholinergic contraindications, caution
Definition
BPH
GI disorders
Asthma
cardiac disorders
hyperthyroidism
Term
Cholinergic interactions
Definition
Procainamide
Quinidine
insecticide: malathion if GI, excess sweating, slow heartbeat, depressed respiration
Term
Cholinergics
Definition
bethanechol/Urecholine
edrophonium/Tensilon
neostigmine/Prostigmin
pilocarpine/Isopto Carpine
Term
bethanechol/Urecholine
Definition
10-50 mg qid
2.5-5mg SQ
urinary retention not BPH
Term
edrophonium/Tensilon
Definition
1-2mg IV then 8mg if no response
tests for myasthenia gravis
Term
neostigmine/Prostigmin
Definition
45-150mgdivided
0.5-2mg IM or IV q1-3h
treatment for myastenia gravis
neuromuscular blockade reversal
Term
pilocarpine/Isopto Carpine
Definition
opthalmic gtts, dose varies
lower intraocular pressure
Term
Cholinergic blockers
Definition
block parasympathetic/parasympatholytic
Atropine is classic
preoperative
atropine is only bronchodilator
Term
Cholinergic blocker actions
Definition
drying secretions
decreased GI and GU motility\
dilation of pupils
Term
Cholinergic blocker uses
Definition
antispasmodic, antisecretory GI & GU
perop and preanesthesia
neuromuscular block, spastic disorders
antidote for insecticide, cholinergic crisis, mushroom poisoning
emergency treatment bradycardia, av block with hypotension
pupil dilation, mydriatic
inhaler, prevention and treatment of bronchospasm
Term
Cholinergic blocker side effects
Definition
blurred vision, headache
dry mouth, constipation, urinary retention
confusion, excitement, older
palpatations, tachycardia
Term
Cholinergic blocker contraindication
Definition
angle closure glaucoma
GI/GU obstruction
cardiac arrhythmias
hypertension
hypothyroidism
potentiates sedation and drying with antihistamines
Term
atropine/Atropine
Definition
preoperative
insecticide, mushroom poisoning,
bradycardia, AV block\
IM/IV
Term
glycopyrrolate/Robinul
Definition
preoperative
IM, IV
Term
propantheline/Pro-Banthine
Definition
PO
bladder spasm
Term
scopolamine/Transderm Scop
Definition
patch
motion sickness
Term
homatropine/Isopto Homatropine
Definition
dropps
mydriatic
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