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Pharmacology Ch. 32
Chapter 32 Antidiabetic Drugs
19
Pharmacology
Undergraduate 3
11/07/2013

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Term

Diabetes Mellitus

Definition
A complex disorder of carbohydrate, fat, and protein metabolism resulting primarily from the lack of insulin secretion by the beta cells of the pancreas or from defects of the insulin receptors; it is commonly referred to simply as diabetes. There are two major types of diabetes: type 1 and type 2.
Term

Diabetic ketoacidosis (DKA)

Definition
A severe metabolic complication of uncontrolled diabetes that, if untreated, leads to diabetic coma and death.
Term

Gestational diabetes

Definition
Diabetes that develops during pregnancy. It may resolve after pregnancy but may also be a precursor of type 2 diabetes in later life.
Term

Glucagon

Definition
A hormone produced by the alpha cells in the islet of Langehans that stimulates the conversion of glycogen to glucose in the liver.
Term

Glucose

Definition
One of the simple sugars that serves as a major source of energy. it is found in foods (e.g., fruits, refined sweets) and also is the final breakdown product of complex carbohydrate metabolism in the body; it is also commonly referred to as dextrose.
Term

Glycogen

Definition
A polysaccharide that s the major carbohydrate stored in animal cells.
Term

Glycogenolysis

Definition
The breakdown of glycogen to glucose.
Term

Hemoglobin A1C (A1C)

Definition
Hemoglobin molecules to which glucose molecules are bound; blood levels of hemoglobin A1C are used as a diagnostic measure of average daily blood glucose levels in the monitoring of diabetes; it is also called glycosylated hemoglobin or glycated hemoglobin.
Term

Hyperglycemia

Definition
A fasting blood glucose level of 126 mg/dl or higher or a nonfasting blood glucose level of 200 mg/dl or higher.
Term

Hyperosmolar nonketotic syndrome (HNKS)

Definition
A metabolic complication of uncontrolled diabetes, similar in severity to diabetic ketoacidosis but without ketosis and acidosis.
Term

Hypoglycemia

Definition
A blood glucose level of less than that 50 mg/dl.
Term

Impaired fasting glucose level

Definition
A fasting glucose level of at least 110 mg/dl but lower than 126 mg/dl; its defines a prediabetic state that is sometimes called prediabetes.
Term

Insulin

Definition
A naturally occurring hormone secreted by the beta cells of the islets of Langerhans in the pancreas in response to increased levels of glucose in the blood.
Term

Ketones

Definition
Organic chemical compounds produced through the oxidation of secondary alcohols (e.g., fat molecules), including dietary carbohydrates.
Term

Polydipsia

Definition
Chronic excessive intake of water; it is a common symptom of diabetes.
Term

Polyphagia

Definition
Excessive eating; is it a common symptom of diabetes.
Term

Polyuria

Definition
Increased frequency or volume of urinary output; it is a common symptom of diabetes.
Term

Type 1 diabetes mellitus

Definition
Diabetes mellitus that is a genetically determines autoimmune disorder characterized by a complete or nearly complete lack of insulin production; it most commonly arises in children or adolescents.
Term

Type 2 diabetes mellitus

Definition
A type of diabetes mellitus that most commonly presents in adults. The disease may be controlled by lifestyle modifications, oral drug therapy, and/or insulin, but patients are not necessarily dependent on insulin.
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