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Pharmaceutics: acidic, basic, neutral fx groups
Acidic, basic, neutral fx groups
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09/28/2011
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Term
[image]
 Definition

Imidazole

Nitrogen 1 is acidic pKa 13-15

Nitrogen 3 is basic pka 3-5

 
Term
[image]
 Definition

Phenol

Acidic

pKa=9-11
Term
[image]
 Definition

Sulfonamide

Acidic (at the Nitrogen)

pKa=9-10
Term
[image]
 Definition

Imide

Acidic (At N)

pKa=9-10
Term
R-SH
 Definition

Alkylthiol

Acidic

pKa=10-11
Term
[image]
 Definition

Thiophenol

Acidic

pKa=9-10
Term
[image]
 Definition

N-Arylsulfonamide

Acidic

pKa=6-7
Term
[image]
 Definition

Sulfonimide

Acidic

pKa=5-6
Term
[image]
 Definition

Alkylcarboxylic Acid

Acidic

pKa=5-6
Term
[image]
 Definition

1,3-Dione

Acidic

pKa=4-5
Term
[image]
 Definition

Arylcarboxylic Acid

Acidic

pKa=4-5
Term
[image]
 Definition

Sulfonic Acid

Acidic

pKa=0-1
Term
[image]
 Definition

Arylamine

Basic

pKa=4-5
Term
[image]
 Definition

aromatic amine

basic

pKa=5-6
Term
[image]
 Definition

imine

basic

pka=3-4
Term
R-NH2
 Definition

Alkylamine

basic

pka=9-10
Term
[image]
 Definition

amidine

basic (at double bonded nitrogen)

pka=10-11
Term
[image]
 Definition

guanidine

basic (at double bonded N)

pka=10-11 
Term
R-CH2-OH
 Definition

Alkyl Alcohol

neutral
Term
R-O-R'
 Definition

Ether

neutral
Term
[image]
 Definition

ester

neutral
Term
[image]
 Definition

sulfonic acid ester

neutral
Term
[image]
 Definition

amide

neutral
Term
[image]
 Definition

diarylamine

neutral
Term
[image]
 Definition

nitrile

neutral
Term
NR4+
 Definition

quartnernary ammonium

neutral
Term
[image]
 Definition

amine oxide

neutral
Term
[image]
 Definition

ketone and aldehyde

neutral
Term
[image]
 Definition

thioether

neutral
Term
[image]
 Definition

sulfoxide

neutral
Term
[image]
 Definition

sulfone

neutral
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