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Pharmaceutics
Parenterals
22
Biology
Graduate
03/27/2012

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Term
sterile products
Definition
-injectables
-ophthalmics
-inhalations
-irrigation fluids
-dialysis
-implants
Term
why parenteral administration?
Definition
Term
parenteral dosage forms
Definition
-drug injection
-drug for injection
-drug injectable emulsions
-drug injectable suspension
-drug for injectable suspension
Term
parenterals unique characteristics
Definition
-sterile
-free of pyrogens
-free of foreign particulates
-isotonic
-compatible with IV diluents and delivery systems and other drugs products co administered
-costly
-requires special skills for administration
Term
pyrogens
Definition
-fever producing substances
Term
sterilize
Definition
-destroy/remove all organisms
Term
disinfect
Definition
implies use of chemicals
Term
preserve
Definition
-stopping the growth
Term
parenteral routes
Definition
-IV
-IM
-SC
-ID
Term
SC
Definition
-under the skin
-45 degree angle
-past dermis
Term
IV route
Definition
-immediate drug action
-beneficial for life saving
-deadly for mistakes
-fluid, electrolyte, nutrition
-dosage forms-solutions, lipid emulsions
Term
IV route history
Definition
-Chris Wren injected solutions and drugs into dogs and watched effects
-given to humans in 1662
-mid 19th century-creation of hypodermic needle
-late 19th century-solutions of NaCl and dextrose
Term
IV route access
Definition
-peripheral veins-antecubital area, dorsal forearm area
-central veins-large veins in thoracic cavity (ex. subclavian vein)
-for irritating drugs or hypertonic solutions
-for patients requiring LT IV therapy
-when a peripheral line cannot be maintained
Term
IV route administration routes
Definition
-continuous infusion
-intermittent infusion
Term
continuous infusion
Definition
-slow, large volume
-for fluid, electrolyte, and nutrient replacement
-for maintaining a therapeutics drug level (mostly drugs with a narrow therapeutic index)
-by gravity or pumps
-flow rates (ml/min, ml/hr,drops/min)
-need to be carefully calculated and monitored
Term
intermittent infusion
Definition
-for medications needed only at certain times
-administration thru mini bags, additive chambers, bolus injection (make sure compatible)
Term
IV route electronic delivery systems
Definition
-improved accuracy. safety, patient convenience
-used for intermittent and continuous infusion
-ex. patient controlled analgesia (PCA)
-compact design
-predictable and consistent drug plasma levels
-dose on demand
-control the pain without overuse of drugs
Term
IV route precautions
Definition
-embolism due to thrombi (blood clots), particulates, air (small amt is ok)
-phlebitis-inflamation of vein
-hypothermia (1g amt of fluid?)
-infection
Term
IM route
Definition
-slower onset than IV
-duration can be longer?
-dosage forms-aqueous and oleaginous solutions
-suspensions (slower onset, longer duration) and emulsions
Term
IM route administration
Definition
-deep into skeletal muscles
-adults-gluteus maximus (<5ml) and deltoid (<2ml)
-infants-upper arm or thigh (<2ml)
Term
SC route
Definition
-beneath skin, into loose interstitial tissue
-upper arm, thigh, lower abdomen (<2ml)
-used for insulin
-thin and short needles
Term
ID route
Definition
-into skin, just beneath epidermis
-anterior forearm (~0.1ml)
-used for skin test and certain vaccines
-thin and short needles
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