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pharm
antidepressants
29
Medical
Graduate
01/28/2009

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Cards

Term
antidepressants indicated for OCD
Definition
clomipramine, fluoxetine, fluvoxamine
Term
neurotransmitters affected by antidepressants
Definition
serotonin, NE
Term
time needed for full effect of antidepressant therapy
Definition
2-3 weeks
Term
used to treat pts with anxiety, phobia, hypochondriasis, resistant depression
Definition
MAO-Is
Term
MAOI + tyramine food (i.e. cheese) causes this
Definition
hypertensive crisis
Term
MAOI + SSRI can cause this
Definition
serotonin syndrome - hyperthermia, muscle rigidity, myoclonus, change in mental status/vitals
Term
TCA side effects
Definition
coma, convulsion, cardiac toxicity
Term
TCA uses
Definition
acute panic attacks, phobias, enuresis, chronic pain
Term
higher sedation and antimuscarinic effects than other TCAs
Definition
tertiary amines
Term
TCA used in chronic pain, hypnosis, antimuscarinic effects
Definition
amitriptyline
Term
TCA used in chronic pain, enuresis, ADD
Definition
imipramine
Term
TCA with greatest sedation effect; marked antimuscarinic effects, used for sleep
Definition
doxepin
Term
TCA used for OCD; highest risk for seizure, weight gain, neuropsychiatric signs/symptoms
Definition
clomipramine
Term
TCAs with less sedative effect, more excitation
Definition
secondary amines (desipramine, notriptyline)
Term
antidepressant associated with neuroleptic malignant syndrome
Definition
amoxapine (heterocyclic)
Term
antidepressant associated with seizure, cardiotoxicity
Definition
maprotiline (heterocyclic)
Term
antidepressant that can increase BP, similar stimulant effects to SSRI
Definition
venlaxafine (heterocyclic)
Term
antidepressant that inhibits NE, serotonin, dopamine reuptake
Definition
venlaxafine (heterocyclic)
Term
antidepressant that can cause priapism, used for sleep
Definition
trazodone (heterocyclic)
Term
antidepressant that inhibits CYP450, ass'd with hepatic failure
Definition
nefazodone (heterocyclic)
Term
antidepressant used to manage nicotine withdrawal, least likely to affect sexual performance
Definition
bupropion (heterocyclic)
Term
side effects of bupropion
Definition
dizziness, dry mouth, aggravation of psychosis, sedation
Term
antidepressant that has alpha-2-antagonist effects, blocks histamine receptors
Definition
mirtazapine (heterocyclic)
Term
side effects of mirtazapine
Definition
liver toxicity, increased serum cholesterol
Term
SSRIs that do not have CYP450 inhibition
Definition
citalopram, escitalopram
Term
SSRI w/ long half life, administered once a week
Definition
fluoxetine
Term
SSRI indicated for premenstrual dysphoric disorder
Definition
fluoxetine
Term
uses of SSRIs
Definition
to treat depression, panic attacks, social phobias, bulimia, premenstrual dysphoric disorder, OCD
Term
SSRI least likely to cause withdrawal symptom
Definition
fluoxetine
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