sk muscle relaxant

depolarizing desensitizing blockade

1. NMDA antagonist

2. increase release of endorphins in brain

adverse effect of HH, rare hereditary problem, rapidly fatal. <!-- /* Font Definitions */ @font-face {font-family:"Times New Roman"; panose-1:0 2 2 6 3 5 4 5 2 3; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:50331648 0 0 0 1 0;} @font-face {font-family:Arial; panose-1:0 2 11 6 4 2 2 2 2 2; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:50331648 0 0 0 1 0;} @font-face {font-family:"Courier New"; panose-1:0 2 7 3 9 2 2 5 2 4; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:50331648 0 0 0 1 0;} @font-face {font-family:Wingdings; panose-1:0 5 2 1 2 1 8 4 8 7; mso-font-charset:2; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:0 0 256 0 -2147483648 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0in; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman";} table.MsoNormalTable {mso-style-parent:""; font-size:10.0pt; font-family:"Times New Roman";} @page Section1 {size:8.5in 11.0in; margin:1.0in 1.25in 1.0in 1.25in; mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;} div.Section1 {page:Section1;} /* List Definitions */ @list l0 {mso-list-id:429935035; mso-list-type:hybrid; mso-list-template-ids:1105781396 -659674616 67698691 67698693 67698689 67698691 67698693 67698689 67698691 67698693;} @list l0:level1 {mso-level-tab-stop:.3in; mso-level-number-position:left; margin-left:.3in; text-indent:-.3in;} @list l0:level2 {mso-level-number-format:bullet; mso-level-text:o; mso-level-tab-stop:45.0pt; mso-level-number-position:left; margin-left:45.0pt; text-indent:-.25in; font-family:"Courier New";} ol {margin-bottom:0in;} ul {margin-bottom:0in;} -->

o  Sk muscles have lrg storage capacity for Ca ions. Ca released at lower levels of depolarization than typical (normally not a problem), but w HH: further causes risk of massive release of Ca at any membrane potential à cause rapid increase in body temp.