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Pharm - PUD
pharm t6
16
Pharmacology
Graduate
04/22/2010

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Cards

Term
3 common causes of PUD"
Definition
1. NSAIDs
2. Stress
3. H pylori
Term
PPI MOA
Definition
irreversibly binds to the H pump on the parietal cells; all p-ways for acid secretion are blocked
Term
H2 MOA
Definition
reversbily binds H2 receptor
Term
first line tx in PUD & duration
Definition
PPI 6-8wks
Term
suffix for PPIs
Definition
azole
Term
6 tx methods for tx resistant PUD
Definition
1. increase strength of PPI
2. increase dose from 1 to 2xD
3. switch to different PPI
4. DC PPI start H2
5. add sucralfate
6. if NSAID induced add misoprostol
Term
6 SE of PPIs
Definition
1. HA
2. D
3. abd pain
4. flatulence
5. constipation
6. rash
Term
PPI with most/least CYP interactions
Definition
most = omeprazole
least - pantopazole
Term
2nd line tx for PUD
Definition
H2 antagonist
Term
suffix of H2 antagonist
Definition
tidine
Term
H2 w no CYP interactions;
Definition
Famotidine
Term
H2 with most CYP interaction:
Definition
cimetidine
Term
SE of H2 antagonists:
Definition
1. constipation
2. D
3. dizzy
4. bradycardia
Term
first line tx for H pylori:
Definition
3 drug combo: PPI+clarithromycin+Amox for 10-14days
Term
indication for 2nd line H pylori tx:
Definition
fail first line after 10-14d
Term
define secondline H pylori tx:
Definition
4 drug combo: PPI or H2 +bismuth+ Metronidazole (or amox or clinda) + tetracycline for 10-14d
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