Term
| define psychosis, what are signs |
|
Definition
disturbance of reality and perception
impaired cognative functioning
inappropirate or bad affect |
|
|
Term
| what are causes of psychosis |
|
Definition
drug abuse
dementia
alzheimers
schizophrenia |
|
|
Term
| prognosis of schizophrenia |
|
Definition
life long, no cure
need drugs all life
usually bad compliance |
|
|
Term
|
Definition
| idiopathic, shows in teens |
|
|
Term
| what are schizophrenia drugs called on the street, man |
|
Definition
neuroleptic agents
major tranquilizers |
|
|
Term
|
Definition
| over action of biogenic amines as NT |
|
|
Term
| positive symptoms of schizophrenia |
|
Definition
exaggerated distorted function
hallucinations, delusions
disorganized behavior |
|
|
Term
| negative symptoms of schizophrenia |
|
Definition
loss of normal function
diminished speech
blunted emotions
loss of energy
inability to experience pleasure |
|
|
Term
| 7 typical anti-psychotic drugs |
|
Definition
pheothiazines
aliphatic - chlorpromazine
piperazine - trifluoperazine
fluphenazine
pierdine - thioridazine
butyrophenones
thioxanthenes |
|
|
Term
| what are the three most potent anti-psychotics, which is most of all |
|
Definition
piperazine - trifluoperazine
butyrophenones
fluphenazine - MOST |
|
|
Term
| which anti-psychotic drugs come in depot form |
|
Definition
butyrophenones
fluphenazine - MOST |
|
|
Term
| in general how to typical anti-psychotics work |
|
Definition
| interact with many NT systems and bind to many receptors antagonizing them |
|
|
Term
| MOA typical anti-psychotic |
|
Definition
mostly antagonize dopamine D2 receptor (which is main one in brain)
physiological depolarization inactivation: initially increases firing at presynaptic neuron and later decreases release
post-synaptic neuron is antagonized entire time |
|
|
Term
| where are typical anti-psychotics acting |
|
Definition
| mesocortical mesolimbic tract |
|
|
Term
| how long does it take for typical anti-psychotics to work |
|
Definition
|
|
Term
| reason for extra pyrmidal side effects of anti-psychotics |
|
Definition
| D2 activity on motor systems |
|
|
Term
| reversible neurological extra pyrmidal side effects of anti-psychotics |
|
Definition
acute dystonia: spasm in face, neck, back early in tx
akathisia: motor restlessness later in tx
parkinsonism
neuroleptic malignant syndrome |
|
|
Term
| what is neuroleptic malignant sndrome |
|
Definition
severe parkinsons
fever
unstable BP |
|
|
Term
| tx neuroleptic malignant sndrome |
|
Definition
DC anti-psychotic
dantrolene |
|
|
Term
| irreversible neurological extra pyrmidal side effects of anti-psychotics |
|
Definition
| tarditive dyskinesia: repetitive tick like movement of face, trunk extremities |
|
|
Term
| what agents most often cause irreversible neurological extra pyrmidal side effects of anti-psychotics |
|
Definition
|
|
Term
| autonomic side effects of anti-psychotics cause |
|
Definition
| a-adrenergic blocking (develop tolerance over time to it tho) |
|
|
Term
| autonomic side effects of anti-psychotics |
|
Definition
hypotension
sedation
stroke in elderly |
|
|
Term
| which antipsychotic most often causes a-adrenergic side effects, which least does |
|
Definition
thioridazine - most
heloperidol - least |
|
|
Term
| endocrine side effects of anti-psychotics cause |
|
Definition
| block tuberoinfundibular dopamine pathway so it cannot regulate prolactin |
|
|
Term
| endocrine side effects of anti-psychotics |
|
Definition
hyperprolactinemia
weight gain
gynecomastia
amenorrhea galactorrhea |
|
|
Term
| side effects specific to thioridazine |
|
Definition
| retinal deposits cause visual impairment |
|
|
Term
| signs of overdose of anti-psychotics |
|
Definition
conduction defects that cause ventricular arrhytmia
probablly taking thioridazine others dont cause it much |
|
|
Term
| general MOA of atypical anti-psychotics |
|
Definition
| more specific to dopamine receptors causing less extra-pyrmidal side effects |
|
|
Term
| 6 atypical anti-psychotics |
|
Definition
clozapine
risperidone
olanzapine
quetiapine
paliperidone
airiprazole |
|
|
Term
|
Definition
high affinity D4
low affinity D2, 5HT2, muscuranic, H1 |
|
|
Term
| side effects of clozapine |
|
Definition
stroke in elderly with dementia
intermediate autonomic effects
severe agranulocytosis so monitor WBC |
|
|
Term
|
Definition
| not first line, last choice |
|
|
Term
|
Definition
clozapine analog
high affinity 5HT2
medium affinity D2 |
|
|
Term
|
Definition
stroke in elderly with dementia
hyperglycemia and diabetes
low extra-pyramid side effects
minimal sedation
increased QT (cannot use CVD) |
|
|
Term
|
Definition
tx negative symptoms of schizophrenia well
first line therapy |
|
|
Term
|
Definition
clozapine analog
high 5HT2 affinity
intermediate D2 affinity |
|
|
Term
|
Definition
stroke in elderly with dementia
hyperclycemia and diebetes
low extra-pyramid effects
minimal sedation |
|
|
Term
|
Definition
lessen symptoms of tardive dyskinesia
first line anti-psychotic
tx negative symptoms of schizophrenia well |
|
|
Term
|
Definition
clozapineanalog
high affinity 5HT2
intermediate D2 affinity |
|
|
Term
|
Definition
stroke in elderly with dementia
hyperglycemia and dementia
low extra-pyrmiad effect
minimal sedation |
|
|
Term
|
Definition
| tx negative symptoms of schizophrenia well |
|
|
Term
|
Definition
active metabolite od risperidone
high affinity 5HT2
intermediate D2 affinity |
|
|
Term
|
Definition
|
|
Term
| paliperidone side effects |
|
Definition
stroke in elderly with dementia
hyperglycemia and diabetes
low extra-pyramid effect
increased QI wave(no use un CVD)
minimal sedation |
|
|
Term
|
Definition
first line therapy
tx negative schizophrenia symptoms well |
|
|
Term
|
Definition
partial D2, 5HT2, 5HT1A agonist (kicks out full agonist lesseing effect)
antagonist 5HT2A, 5HT7
affinity for H1, a-adrenergic, D4
no affinity for cholinergic receptors |
|
|
Term
|
Definition
| stroke in elderly with dementia |
|
|
Term
|
Definition
anti-psychotic
bipolar disorder
major depression |
|
|
