Term
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Definition
Muscarinic at end organ, Nicotinic at ganglia or skeletal m., formed by choline acetyl transferase (ChAT)- Acetyl CoA + choline, primary NT of Parasymp., NT at thermoreg sweat glands (symp, muscarinic receptor), Ach is broken down by acetylcholinesterase with in seconds or diffuses from synaptic space, very high Ach can cause activation at NMJ -fasciculations 1. NAChR- Channel opening (NA/K nonsel), very rapid, needs 2 Ach mol to open
2. MAChR- G-protein activation- slower, binding of 1 Ach causes coformational change
M1,M3,M5= increase PKC, increase Ca
M2, M4= decrease cAMP and hyperpol cell |
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