Term
|
Definition
| =Tylonol. Converted by Glucoronication to a non-toxic metabolite, or converted via CYP2E1 to a toxic metabolite, then converted to a nontoxic thing vis GST. Alcohol induces CYP2E1 --> liver toxicity. Clearance and effective dose increased with increased body weight. |
|
|
Term
|
Definition
| Induces enzyme that makes acetominophen into a toxic compound => liver damage |
|
|
Term
|
Definition
|
|
Term
|
Definition
| treat malaria. Very high Vd, is bound in tissues. Side effects: nightmares and hearing loss. |
|
|
Term
|
Definition
| is a prodrug, not active until converted to morphine. fast entry into brain, but metabolized in the liver by CYP2D6, so low addiction potention. |
|
|
Term
|
Definition
| = Digitalis. Binds in muscle (high Vd).↑ contractility, ↓ conductivity, ↓ heart rate. Acts by stimulating Ach release. use in CHF and atrial fib. inhibits K/Na ATPase and inhibits AV node conduction. Narrow TI can lead to Digoxin toxicity. Quick onset of action, long half life. |
|
|
Term
|
Definition
| Loop Diuretic, blocks TAL K/Na/Cl transporter. Treat CHF and HTN. Side effect: venodilator. 70 percent bioavailability. |
|
|
Term
|
Definition
| Antimicrobial. Inhibits protein synthesis in bacteria. Cleared by kidney |
|
|
Term
|
Definition
| Tuberculosis. Inhibits synthesis of microbial cell wall. Metabolized by NAT2: give lower dose to slow acetylators. |
|
|
Term
|
Definition
| Hypertension. Inhibit SNS (b1, b2, a1 antagonist). Decreases systemic vascular resistance. Give along with diuretics to a person with v high blood pressure. oral: 20 percent bioavail. rare side effect: liver failure. |
|
|
Term
|
Definition
| Very fast acting anesthetic--dont think you had surgery. Lipid soulble, so quickly enters and leaves the brain to go to other fat tissues(30 mins). |
|
|
Term
|
Definition
| b blocker. HTN. also: local anesthesia and migrane prophylaxis |
|
|
Term
|
Definition
| Anti-seizure drug. Hepatic clearance. low doses 1st order, high doses 2nd order. Long t1/2, peaks at 3-12 hrs. Give drug more times per day at a lower dose to avoid toxicity. |
|
|
Term
|
Definition
| anti-coagulant. narrow TI, bad adverse effects. |
|
|
Term
|
Definition
| barbituate, seditive. interacts with warfarin metabolizm via CYPs. Must give more Warfarin |
|
|
