Details Title: Pharm Ischemic Heart Disease Description: Pharm Ischemic Heart Disease Total Flash Cards: 13 Created: 05/28/2009 14:49:53		New Users: To study from this flashcard set, or to create your own your own study flash cards, REGISTER HERE. Existing Users: CLICK HERE. Additional Fine Art Flashcards
Cards in this set: Term NO signaling cascade Definition increases cGMP production which relaxes vascular smooth muscle Term Statins: target Definition HMG CoA Reductase Term Statins: Mechansim Definition Competitive inhibition of HMG CoA Reductase Term Statins: Pharm effects Definition Decreased plasma LDL levels, decreased vascular inflammation, improved endothelial cell function Term Statins: adverse effects Definition hepatotoxicity (serum aminotransferase), skeletal myopathy (serum creatine kinase), teratogen (avoid during pregnancy) Term Statins: PK Definition metabolized by CYP3A4 or CYP2C9; potential drug interactions (warfarin) Term Statins: uses Definition CAD (primary and secondary prevention) Term Aspirin: target Definition Cyclooxygenase (COX-1) in platelets Term Aspirin: mechanism of action Definition irreversible acetylation of enzyme at active site Term Aspirin: pharm effects Definition reduced synthesis of thromboxane A2 Term Aspirin: adverse effects Definition hypersensitivity (aspirin induced asthma), slightly prolonged bleeding time Term Aspirin: PK Definition oral administration, renal excretion Term Aspirin: uses Definition antithrombotic effect in patients at risk for CAD