Term
Antifungals
Amphotericin B |
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Definition
-damages the ergosterol of fungal cell membranes
-GOLD STD
-nephrotoxic- hydrate and give slowly IV
-m BUN before giving dose
-broad spectrum
-fav for brain lesions, does NOT cross BBB
- |
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Term
Antifungals
Amphotericin B
Lipid Preps |
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Definition
-decrease renal tox
-can be phagocytosed by M0
-slow release of drug |
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Term
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Definition
-reduces inflammation by inhibiting leukotrienes
-inhibits prod of ergosterols in fungal cell membrane
-inhibit prod of steroid hormones
-advocated for use in Cushingoid dogs
-produces anorexia and heptaic tox in cats
-cheap |
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Term
|
Definition
-pellets --> given with food (lipid soluble)
-liquid --> empty stomach
-avoid antacids/antihistamines
-tx of blasto/histo
-long 1/2 life
-low tox, broad spectrum
-STOP if anorexia occurs, start back at 1/2 dose
-m for ulcerative skin leasions and vasculitis |
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Term
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Definition
-penetrates eye and nervous system
-best against Cryptococcus, Coccidiomycosis, Candida
-excreted in urine
-m for hepatic tox |
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Term
Antifungals
Voriconazole/Posaconazole |
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Definition
-good against Aspergillus
-systemic infections
-expensive |
|
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Term
|
Definition
-topical azole
-used for Aspergillus in nasal passages |
|
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Term
|
Definition
-broad spectrum
-oral
-interferes with ergosterol synthesis
-cats with cryptococcosis
-use when infection is resistant to other azoles |
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Term
Antifungals
Glucan synthesis inhibitors
Caspofungin |
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Definition
-effective in vitro against Aspergillus terreus
-IV use only, $$$ |
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