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Pharm II unit 1 chapter 4
Parenteral Solutions
127
Nursing
Undergraduate 1
08/30/2011

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Cards

Term
For a Nurse safly give parenteral theripy what two thing must the nusre understand
Definition

1. the reason for infution theripy 

 

2.the type of solution, it's composition, and clinical use.

Term

What are the 3 goals for Parenteral Solutions?


(type of theripys)

Definition

1. maitenace therapy- daily body requierments.

2.replacement therapy- losses such as blood...

3.restoring homeostasis- fluis and electrolytes.

 

Term
Maintenance therapy:
Definition
  1. fluids that provide all nutrients necessary to meet daily patient requirements
Term
when giving Maintenance therapy  what portion of the theripy gets priority?
Definition

Water!!!!!

 

 

Term
how much fluid is needed per Kg of body weight a day
Definition

30 ml. 

 

 

 

Term
how much fluid is lossed from insensible losses a day?
Definition
500-1000 ml/ 24 hr
Term
what are the four main uses of glucose in Maintenance therapy. 
Definition

1. Improves hepatic function

2. supplies calories.

3. spairs protein loss.

4. minimizes ketosis.

Term
why might a pt need Maintenance therapy.
Definition

a pt that is NPO for surgery.

 

Term
Replacement therapy is for what type of pt?
Definition

a pt in acute distress that need fluids , electrolytes and/or blood.

 

ex: hemorrhage, low platelet count, V/D, starvation

Term

when should the MD order Replacement therapy. 

 

Definition
when the maintenace requierments of the body cannot be met.
Term

In what time frame is the Replacement therapy given.

 

Definition

given over 48 hours.

 

 

Term

FUN FACT!!!


what is the > amount of potassium you can give in 24 hours if pt is not on telle.

Definition
120 mEq
Term

what groups of pts are you most concerned about when reciving repacment potassium.

 

Those whith dysfunctios of the:

Definition

Renal system

cardiovascular system

adrenal glands

pituitary gland

Term

what groups of pts are you most concerned about when reciving repacment potassium.

 

those that are deficient of what:

Definition

sodium

Calcium

base bicarbonate

blood vol. (hypovolemic)

Term

what groups of pts are you most concerned about when reciving repacment potassium.

 
Those with excess of:
Definition

base bicarbonate

extracellular potassium

extracellular calcuim

Term
Pt's reciving saline or glucose infutions are pron to develop what?
Definition
Potassium deficiency
Term
what other things can cuase (K)+ deficency
Definition

stress

excreation in urin

tissue injury

↓ in diet

diarrhea

Term
Restorative therapy is for what patients 
Definition

                                                                                                   Restorative therapy is for those patients who's fluid imbalince  can not be turned around in 48 hours

Term

Restoration Therapy


What arethe causes of the loss of fluid and electrolytes

Definition
typically draining fistulas, abdominal abscesses, burns, large abdominal wounds and nasogastric suction ect.
Term
TPN is usually given via  what type of IV?
Definition
a central line 
Term
when a pt has continuse fluid loss what do you need to document.
Definition

Intake and out put is critical for these pts.

 

also daily weights and a complete head to toe assessment.

Term

What isThird spacing?

Definition

Movement of fluid into interstitium or body cavity where it becomes trapped and useless to the body (peritoneal, pericardial, pleural, synovial, greater interstitium).

 

-May be localized or generalized.

Term

Third spacing is associated with...

Definition

-Low albumin

-Increased capillary permeability 

-Inflammation

 

bowl obstruction, burns, ascites, trauma, cancers and sepsis

Term
Third spacing complications...
Definition

If translocation of fluid depletes fluid in the intravascular area: hypovolemia, hypotension, shock & death.

Term
How do you moniter third spacing
Definition

accurate I/O

 

blood pressure

 

weight is not reliable!!

Term
What is the Parkland formula used for
Definition
to calculate fluid reuscitation in burn pts
Term
when using the Parkland formula how would you admister the fluid over the first 24 hours.
Definition
1/2 of total is to be give in the first 8 hours. 1/4 the next 8 hours, and 1/4 again for the next 8 hours.
Term
Show me the Parkland formula :
Definition

4ml of lactate solution x Kg of body waight x % of TBSA BURND

 

EXAMPLE

4ml x 10 kg x 50% = 2000 ml

Term
What is a key ingredient in all IV solutions and necessary for kidney function?
Definition
Water 
Term
what populations of pts needs more water?
Definition
patients with fevers, high respiratory rates, poor renal concentration ability and the elderly 
Term
What two physiologic mechanisms assist in regulating body water?
Definition
Thirst and ADH
Term
Glucose is in what form in IV theripy? 
Definition
dextrose-is the most common component IN Iv therapy
Term
how many grams of glucos is in 1 L of 5% dextrose?
Definition
50 g
Term
what is the minimum amoun of glucose needed  a day to avoid starvation and muscel loss
Definition
100 gram
Term
In what two types of theripy are vitamins added to IVs
Definition

restorative and replacement

 

Term
what two vitamins are the most frequently used in IV theripys.
Definition
B, C
Term
what builing block of nutrion is esential for wound healing?
Definition
Amino Acids
Term
what is the daily requirment  of protein?
Definition
1g/kg of body weight
Term
Electrolytes are commonly seen in restorative and replacement therapies. They include :
Definition

K+, Na+, CL-, magnesium, Phosphorus,

Ca++, Hco3,  and acetate

Term

The pH of IV solutions is slightly acidic.

True of False?

Definition
True
Term
if a patient’s acid-base balance is out of whack—additives are given by what method? 
Definition
IV push to correct imbalances. They are rarely corrected via an IV hanging solution.
Term

Hypotonic solutions higher serum Osmolarity by causing fluid to move out of the blood and into the cells and interstitial spaces.


True or Fales?

Definition

Fales

 

Hypotonic solutions lower serum Osmolarity by causing fluid to move out of the blood and into the cells and interstitial spaces

Term

what is the purpus of a Hypotonic solution?

 

Definition
to hydrate the intracellular and interstitial compartments and lower sodium levels.
Term

What is Tonicity

Definition

the quantity (concentration) of substances dissolved in the water.

Term
What is Oncotic (Colloidal) Pressure
Definition

The pull exerted by substances with a higher molecular weight, which draws water towards itself, thus keeping fluid within the intravascular space.

Term
what is osmotic pressure?
Definition

The power to draw water toward an area of greater concentration

Term

Isotonic solutions have the same or close to the same Osmolarity as the patient’s Blood serum.

 

True or Fales

Definition
True
Term
 Isotonic solutions are typically used to treat what conditions?
Definition
hypotension resulting from hypovolemia and hypernatremia.
Term
Why are  Isotonic solutions used to treat hypotension resulting from hypovolemia and hypernatremia
Definition
solutions have the same tonicity as body fluids. Because of this they do not alter the fluid compartments
Term
what type of isotonic soulution is used to treat dehydration?
Definition
5% D/W
Term
What should the nurse be aware of when giving a dextrose solution?
Definition
this soulution though isotionic , becomes hypotonic when dextrose is metabolized. 
Term
What types of pts should a nurse use extra caution when giving a dextrose solution?
Definition
pts with reanal or cardiac disease
Term

Hypotonic solutions dehydrate cells.

 

True or Fales?

Definition

Fales

 

These solutions are used to hydrate the intracellular and interstitial compartments and lower sodium levels.

Term
Do Hypotonic solutions higher or lower serum Osmolarity?
Definition

Lower

by causing fluid to move out of the blood vessels and into the cells and interstitial spaces.

Term
Examples of hypotonic solutions are:
Definition
0.45% NS, and 2.5% DW
Term
how doHypertonic solutions raise serum Osmolarity?
Definition
by pulling fluids from the intracellular and interstitial spaces into the blood vessels.
Term
Great care should be given when administering hypertonic solutions to patients who have :
Definition
heart and kidney disease
Term
what can happen to RBC when giving Hypertonic solutions?
Definition

they shrink up as water is drawn out of the cells. This is known as crenation.

 
Term
Examples of Hypertonic solutions:
Definition

5% dextrose in 0.45% Na chloride

5% D/W in Na chloride

5% D/W in LR

10% D/W and colloids

Colloids

Term
Crystalloids are materials that are capable of  what?
Definition
crystallization—so when they are mixed into a solution they dissolve
Term

Crystalloidscan diffuse across cell membranes.

 

True or fales?

Definition
True
Term
what apperinces do crystalloids have?
Definition
Clear.
Term
____________ do not dissolve.
Definition

Colloids

*so they cannot form a true solution

Term

Colliods are too small to pass through cell membranes.

 

True or Fales?

Definition

Fales

They are too large to pass through cell membranes

Term
Colloids should apper _________.
Definition
cloudy.
Term
What concentrations does Dextrose come in.
Definition

5%, 10%, 20% and 70% in TPN solutions.

and 50 % for push

Term
what are the clinical usues for dextrose soultions?
Definition
Hydration-to replace water losses, provide free water, provide a few calories and to dilute medications.
Term
What are the disadvantages of Dextrose?
Definition

vein irritation , thrombosis, osmotic dehydration

hyponatremic encephalopathy ( in 5%)

Term

why should you never suddenly stop TPN or any high concentration dextrose solution?

 
Definition
When high serum glucose levels exist –high levels of insulin accompany it. If the dextrose is suddenly stopped or severely cut back rate wise a serious hypoglycemia can occur due to the lagging behind high insulin levels.
Term

dextrose 5% is offten given with blood?

 

True or fales?

Definition

Fales

Dextrose 5% causes hemolysis

NS it is the ONLY solution that is used with blood.

Term
Normal saline is also called..
Definition
sodium chloride
Term

Normal saline has equill parts sodium and chloride.

 

True or fales?

Definition

True

Normal saline has 154 mEq of sodium and 154 mEq of chloride

Term
NS (Normal saline) is avalible in what %s
Definition
 0.25%, 0.45%, 0.9% and 3%. 
Term
What can NS be used for?
Definition

treat: shock, hyponatremia,  metabolic alkalosis,

 

replace ECF losses

 It is also used to dilute medications, irrigate intravascular devices and to administer blood

Term
What are  the disadvantages of NS that the nurse should be aware of?
Definition

acid-base imbalances-acidosis can occur due to high chloride levels that lead to bicarbonate losses,

 

hypernatremia, hypokalemia, and circulatory overload.

Term
what % of NS is considered hypotonic?
Definition
0.45%
Term
what is hypotoinic NS used for?
Definition
supply daily salt needs
Term
what % on NS is considered hypertionic?
Definition
3-5%
Term
What is hypertonic NS used for?
Definition
it is ONLY used to correct sever sodium depletion and water overload !!!!!!
Term

NS 3-5% is hyperosmolar so the nusre shoul fallow what step to give it safely. Choose all that apply

 

  • check serum Na levels before and during administation
  • If not corected after first dose pt needs to be on a ICU unit
  • moniter for pulmonary edema
  • give in few but large volumes
  • always put it on a pump
Definition

corect: check serum Na levels,moniter for pulmonary edema, always put it on a pump

 

incorect:

If not corected after first dose pt needs to be on a ICU unit. Pt need to be on an ICU unit before starting the first does.

give in few but large volumes. Only give small volumes!!!!!

Term
what is NS with dextrose?
Definition
to the NS 100g of dextrose is added
Term
what is the beifit of adding dextrose to NS
Definition
it prevents Catabolisum.
Term
what are the uses of NS with dextrose?
Definition

it is best used for excessive loss of fluid through sweating, vomiting, or NG suctioning.

 

also shock and hypovolemia, burns.

 

 

Term
What are the disavantages of NS with dextrose?
Definition

Same as for NS.

 

hypernatremia, hypokalemia, and circulatory overload.

Term
what are hydration fluids used to test?
Definition
they are used to test the status of the kidneys
Term

Using hydration fluids how would a nurse test the status of the kidneys 

(also called a fluid challenge)

Definition

start the solution at a rate of 8ml/m2 of BSA pre min for 45 min

when the pt has to urinate you know they have kidnys are functioning. 

 

 

Term

during a fluid challenge if a pt in not voiding after 45 min

how should the nurse proceed?

Definition

reduce the rate of infution ,

 

the IV hung  not contain any electrolyte additives, esp- K+ 

Term
What are  common types of hydrationfluids?
Definition

combinations of dextrose and Hypotonic NS

 

5% dextrose in 0.45% NS

 

Term
why are hydraton soultions K+  free?
Definition
Thoug K+ is needed int he body it can be toxic to the kidnys if not functioning properly
Term
In what typs of pt do you need to uses extra caution with when giving hydrating solutions?
Definition
Pts with cadiac, renal or liver diseases.
Term
what is the most common multiple electrolyte solution?
Definition
 Lactated Ringer’s
Term
LR (Lactated Ringer’s) solution is given when the electorlyte concentration closely resembles the ___  compartment.
Definition
ECF
Term

Lactated Ringers and Ringers Injection are the same solution 


True or Fales?

Definition

Fales

 

Notice that Lactated Ringers and Ringers Injection are two different solutions both are isotonic but the concentration of electrolytes is different

Term
LR contains what two electrolights unlike others soulutions?
Definition
calcium and magnesium
Term
what type of LR would you give to a pt with liver dysfunctions?
Definition
Ringers injection 
Term
ringers injection is used for what 
Definition

treatment of dehydration

fluid balance befor and after surgery

replacemrnt of fluids

Term

ringers injection may be used as a substition for blood for a short piriod of time.

 

true or fales?

Definition
true
Term

Does RINGERS INJECTION proide calories?

 

 

Definition
NO
Term
What are the complications associated with ringers injection that nurses are most concerned about?
Definition

Sodium Retention

Congestive Heart Failure

Renal Insufficiency

 

Term
Ringers injection is contraindicated in what type of patient?
Definition
Renal Failure
Term
What is Lactated Ringers (LR) solution used for?
Definition

Rehydration

Restoration

Replacement

Metabolic Acidosis

Salicylate Overdose

Term

LR does not elivate sodium levels

 

True or False

Definition

False

 

LR contains 390 meq of sodium that can quickly raise sodium levels.

Term
LR soultion should not be used in what type of pts?
Definition

Liver Disease

Addisons Disease

 

Severe: Metabolic Acidosis, Alkalosis, Hypovolemia, Shock

 

Cardiac Failure

 

Term
What is the first fluid choice for hypovolemia trauma pts?
Definition
Sodium Chloride (NS)
Term
When a nurse is administering a crystalloid solution what must they assess in the pt?
Definition

Presence of any Fluid Loss

Renal Function

Vital Signs

Weight

S/S of fluid imbalance

 

Term
What do all colloid solutions contain?
Definition
Protein and Starch
Term
What type of solution is referred as plasma volume expander?
Definition
Colloid Solution
Term
How long will the colloid molecules remain in the vascular space after administration?
Definition
Several Days
Term
Do colloids increase or decrease osmotic pressure within the venus space?
Definition

Increase

 

This draws fluid into the intavascular space.

Term
What are the most common types of colloids?
Definition

Dextran

Albumin

Hetastarch

Mannitol

Gelatin

Term

Choose all that apply

Advantages of colloid solutions include:

 

  • distributes into all body compartments
  • long shelf life
  • inexpensive
  • stores at refrigerator temp
  • doesn't interfere with blood 

 

Definition

Correct:long shelf life, inexpensive, doesn't interfere with blood

 

Incorrect: it should only distribute within the intravascular space, no special storage is required

Term
what is albumin?
Definition

a plasma protein. 

 

A type of colloid.

Term
Albumin comes in  What %s
Definition
5% , 20% or 25%
Term
what % of albumin is = in osmotically/oncotically to plasma?
Definition

5%

 

this means that it is isotonic

Term
5% albumin is used for what type of pt?
Definition

hypovolemic 

or pts on bypass

Term
Albumin typically is administered by____ -over __ minutes
Definition
by itself, 20 min
Term
25% albumin is used for:
Definition

For pts that fluids and Na intake should be limited.

 

hypoproteinmia, hypovolemia, burns, acute nephrosis, bypass.

Term
Is 20-25% albumin hyper or hypo tonic?
Definition
hypertonic.
Term

how much will Albumin 25% increase plasma volume by

-for every 100 mls given


(in ml)

 

Definition

500 ml

 

this means it draws this amount towards it in the vascular space.

Term
during administration of albumin assess for S&S of:
Definition
fluid overload and hypersensitivity
Term
Mannitol is typically given to reduce _______ and _______.
Definition
ICP and cerebral edema
Term

Whta is .Mannitol?

 

Definition
It is a sugar-alcohol substanc
Term
what elces can Mannitol be given for?
Definition
promote diuresis, and in glaucoma to reduce intraocular pressure.
Term
Hetastarch is similar to what other colliod? 
Definition

Albumin

 

but because it is a synthetic substance there are no incompatibility issues

Term
When before giving Hetastarch  the nurse should check for what?
Definition
It can cause blood coagulation abnormalities so screening for blood disorders is important.
Term
What is a critical consideration with all colloids?
Definition
because they do not cross the capillary membranes if there is disruption of blood vessel walls –such as in burns—the colloids will move into the interstitial space and draw fluid into those areas causing edema
Term
how does bicarb afect K+  leves
Definition
it chanes the pH when the pH is low then K+ gose out of the cell highering the serum K+
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