Term
|
Definition
leuprolide
grosereline
nafarelin
histerlin
triptorelin |
|
|
Term
|
Definition
ganirelix
cetorelix
abarelix
degarelix |
|
|
Term
|
Definition
|
|
Term
| 2 GH antagonists / somatistatin agalons |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Lutropin / recombinant hCG |
|
|
Term
|
Definition
|
|
Term
| 2 prolactin antagonist, 1 AKA |
|
Definition
aka: dopamine agonist
bromocriptine
cabergoline |
|
|
Term
| 2 vasopressin agonist and their receptors |
|
Definition
8-L-arginine vasopressin (V1)
desmopressin (V2) (tetracycline antibiotic) |
|
|
Term
| 3 vasopressin antagonists and their receptors |
|
Definition
conivaptin (V1+V2)
tolvaptin (V2)
lithium (V2) |
|
|
Term
|
Definition
control FSH and LH release
pulsatile (replacement) therapy: increases release
continous (supression) therapy: inhibits release |
|
|
Term
|
Definition
| stops release of FSH and LH |
|
|
Term
|
Definition
| longitudinal growth via ILGF-1 and some ILGF-2 |
|
|
Term
|
Definition
| complex of ILGF-1 and ILGF binding protein 3 that causes growth |
|
|
Term
|
Definition
| somatostatin agonist stop GH, glucagon, insulin, and gastrin release |
|
|
Term
|
Definition
|
|
Term
| where do menotropins come from |
|
Definition
|
|
Term
| where does urofollitropin come from |
|
Definition
|
|
Term
| where does lutropin come from |
|
Definition
| recombinant LH (identical to hCG so it can be used) |
|
|
Term
|
Definition
|
|
Term
| how does a prolactin antagonist work |
|
Definition
| dopamine agonist decreases prolactin release |
|
|
Term
| why would some have increased prolactin (2) |
|
Definition
anti-psychotic drugs (dopamine receptor blockers)
prolactinoma |
|
|
Term
| what happens when prolactin is increased (4) |
|
Definition
amenorrhea
no ovulation
galactorhea
breast tenderness |
|
|
Term
|
Definition
| induces myometrial contraction by changing ion concentrations |
|
|
Term
| what does ADH to do V receptors (8), what type of receptor |
|
Definition
Gq receptors
V1a: vasoconstriction, glycogenolysis, platelet aggregation, ACTH release
V1b: ant pituitary, pancrease, brain, adrenal medulla |
|
|
Term
| what tissues have V2 ADH receptors on them, what type of receptor is it |
|
Definition
| Gs receptor on aquaporin 2 on collecting duct cells |
|
|
Term
| GnRH agonist side effects |
|
Definition
| continous therapy gives flare in condition prior to supression (desensitization) |
|
|
Term
| GH antagonist side effects (5) |
|
Definition
flatulence
steratorrhea
biliary sludge
gall stones
sinus bradycardia |
|
|
Term
|
Definition
simillar to ADH
water retension or intoxication (if on IV) |
|
|
Term
|
Definition
| mimics nephrogenic diabetes insupidus |
|
|
Term
| how can GnRH be administered |
|
Definition
pulastile: every 1-4 hours
continous |
|
|
Term
| why is administering GnRH different than just giving the hormone (gonadorelin) |
|
Definition
| the half life of the drug will be longer than administering the hormone |
|
|
Term
| what is the benifit of using a GnRH antagonist over agonist (2) |
|
Definition
no flare in hormone levels before supression
more rapid onset |
|
|
Term
|
Definition
B blockers
Mg sulfate
inhaled anasthetics |
|
|
Term
| what is pulsatile GnRH used for (3) |
|
Definition
infertility
delayed puberty
hypogonadism |
|
|
Term
| what is continous GnRH used for (4) |
|
Definition
endometrosis
uterine fibroids
prostate cancer
central precoious puberity |
|
|
Term
| when do you decide to treat central precoious puberty |
|
Definition
| before 8 in girls and before 9 in boys |
|
|
Term
| how is prostate cancer treated (2) |
|
Definition
GnRH agonist with androgen receptor blocker to inhibit flare
OR
GnRH antagonist |
|
|
Term
| what do GnRH antagonists treat |
|
Definition
prostate cancer
ovarian hyperstimulation
prep for in vitro fertilization |
|
|
Term
| why is GnRH antagonist used for prep for in vitro fertilization |
|
Definition
| prevents premature LH surge |
|
|
Term
| what is somatropin used for (3) |
|
Definition
GH deficiency (<4cm/y)
Growth failure: prader willi, turner syndrome, AIDS wasting
idiopathic short stature |
|
|
Term
| what is mecasermin used for |
|
Definition
| patient is deficient in ILGF-1 and exogenous GH isnt working |
|
|
Term
|
Definition
DOC for acromeagly and gigantism
hormone secreting tumors
bleeding esophageal varices |
|
|
Term
| what causes acromeagly and gigantism |
|
Definition
|
|
Term
| what are 4 GH secreting tumors |
|
Definition
gastrinoma
glucagonoma
carcinoid secreting tumors
carcinoid syndrome |
|
|
Term
| what is carcinoid syndrome |
|
Definition
| carcinoid tumor with liver metastasis and serotonin secretion |
|
|
Term
| what is the use for pegvisomant |
|
Definition
| acromeagly third alternative |
|
|
Term
|
Definition
| induce spermatogenesis or ovulation in infertility |
|
|
Term
| use of prolactin antagonist (2) |
|
Definition
hyperprolactinemia
bromocriptime: acromeagly 2nd alternative |
|
|
Term
|
Definition
lactation in natural doses
pharmacological doses: control post partum hemorrhage, induce labor but causing uterine contraction |
|
|
Term
|
Definition
| vasoconstriction stops bleeding esophageal varicies, post-op ileus, abdominal distension |
|
|
Term
|
Definition
central diabetes insipidus
SIADH |
|
|
Term
| use of V1/V2 antagonist (2) |
|
Definition
euvolumeic or hypervolemic hyponatremia
SIADH |
|
|
Term
| what is diabetes insipidus |
|
Definition
| increased ADH due to pituitary or hypothalamus trauma or tumor |
|
|
Term
| what is nephrogenic diabetes insiputis |
|
Definition
| broken V2 receptors on nephron |
|
|
Term
| what categories of drugs are hypothalamic hormone drugs (2) |
|
Definition
GnRH/gonadorelin agonist
GnRH antagonist |
|
|
Term
| what categories of drugs are anterior pituitary hormone drugs (8) |
|
Definition
GH agonist
GH antagonist
GH blocker
FSH + LH
FSH
LH
prolactin agonist
prolactin antagonist |
|
|
Term
| what categories of drugs are the posterior pituitary hormone drugs (4) |
|
Definition
oxytocin
vasopressin agonist
vasopressing antagonist
lithium |
|
|
