• Class 1A Sodium Channel Blocker
• Slows conduction velocity
• Prolongs refractory period
• Supraventricular tachycardia

• Class 1B Sodium Channel Blocker
• Little change in conduction velocity
• Shortens Refractory period
• Binds inactivated NaCh to keep them inactivated
• Decreased automaticity
• Ventricular tachycardia

• Class 1C Sodium Channel Blocker
• Little change in refractory period
• Profound decrease in conduction velocity
• Used with life-threatening arrhythmias
• V-tach, V-fib, refractory supraventricular tachycardia

Class II Beta Blocker

B1 selective

For too much SANS activity

Can slow AV nodal conduction; A-fib

• Class III Action potential prolonging drugs
• Blocks KCh to increase refractory period
• No effect on NaCh
• No change in conduction velocity
• For Re-entrant supraventricular tachycardia
• Side effects: Arrhythmia from AP prolongation, pulmonary fibrosis, thyroid problems, derm rashes or Smurf discoloration

• Class IV Calcium channel blocker
• Slow AV nodal conduction
• Generally well tolerated
• Inhibit Cardiac CaCh in cardiac myocytes and nodal cells
• Decrease ventricular response to A-fib
• High dose = AV block

• Class IV Calcium channel blocker
• Slow AV nodal conduction
• Some decrease in contractility (problem with CHF)
• Generally well tolerated
• Inhibit Cardiac CaCh in cardiac myocytes and nodal cells
• Decrease ventricular response to A-fib
• High dose = AV block

• Misc. Antiarrhythmic
• Decrease AV nodal conduction
• Decrease ventricular response to A-fib

• Misc. antiarrhythmic
• ATP without the TP
• blocks AV nodal conduction; terminate supraventricular tachycarida s involving the AV node
• 5s half-life; IV only