Term
| Insulin lispro is what type of drug? |
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Definition
| Ultra-Short Acting Insulin |
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Term
| Insulin aspart is what type of drug? |
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Definition
| Ultra-Short Acting Insulin |
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Term
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Definition
| Ultra-Short Acting Insulin |
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Term
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Definition
| Short Acting Insulin Preparation |
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Term
What drug is a Recombinant that is identical to human insulin?
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Definition
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Term
| Regular insulin Needs to be given.... |
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Definition
30 to 45 minutes before meals
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Term
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Definition
| intermediate acting insulin |
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Term
| NPH is a complex of ___ & __ |
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Definition
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Term
| What does NPH Require for absorption? |
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Definition
| proteolytic degradation of protamine for absorption of insulin |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| HbA1c target should be < or = __ |
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Definition
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Term
Fasting Self-monitored glucose should be < ___ mg/dl
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Definition
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Term
Post-prandial glucose (self-monitored) should be < ___-___ mg/dl
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Definition
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Term
______-_____ units/kg/day- titrated to glycemic targets
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Definition
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Term
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Definition
| 1st generation sulfonylurea |
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Term
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Definition
| 1st generation sulfonylurea |
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Term
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Definition
| 1st generation sulfonylurea |
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Term
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Definition
| 2nd generation sulfonylurea |
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Term
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Definition
| 2nd generation sulfonylurea |
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Term
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Definition
| 2nd generation sulfonylurea |
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Term
| Sulfonylureas: Mechanism of Action: |
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Definition
Block ATP-sensitive K+ channel
Leads to depolarization and influx of Ca++
Results in insulin secretion
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Term
"Extrapancreatic Effects” of sulfonylureas MOA unknown (2)
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Definition
1.) SUs indirectly increase tissue sensitivity to insulin, i.e., help overcome insulin resistance
2.) Help suppress hepatic glucose output
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Term
| longest acting sulfonylurea? |
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Definition
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Term
_______ sulfonylurea w/ highest frequency of side effects, including hypoglycemia (related to t ½)
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Definition
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Term
Use Chorpropamide cautiously in ____ and patients with ___ ro _____ impairment
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Definition
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Term
| Which generation of Sulfonylureas are more potent? |
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Definition
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Term
Which generation of Sulfonylureas has less severe/persistent hypoglycemia?
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Definition
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Term
| What is a significant drug interatction of sulfonylureas? |
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Definition
ETHANOL
Disulfiram-like interaction with ethanol (especially chlorpropramide)
Ethanol inhibits gluconeogenesis- can potentiate the hypoglycemic response
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Term
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Definition
| Non-Sulfonylurea Secretogogues |
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Term
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Definition
| Non-Sulfonylurea Secretogogues |
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Term
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Definition
| [Glucophage] (Biguanide) - Anti-diabetic drug |
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Term
Metformin has ____ action, not ____, “euglycemic”
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Definition
Antihyperglycemic
hypoglycemic |
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Term
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Definition
no weight gain
no hypoglycemia
significant lipid lowering effect
works in patients that are insulin resistant
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Term
| Metformin Concern is ___ (but rare), contraindicated in: (3) |
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Definition
lactic acidosis
Renal or hepatic insufficiency
Cardiac Failure
Hypoxic lung disease
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Term
Combinations of anti-diabetic drugs combine the insulin releasing effect of ____ with increased glucose utilization & decreased hepatic glucose output of ___
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Definition
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Term
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Definition
Combination of Glyburide and Metformin
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Term
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Definition
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Term
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Definition
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Term
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Definition
Metformin + Rosiglitazone
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Term
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Definition
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Term
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Definition
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Term
| a-Glucosidase Inhibitors MOA: |
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Definition
Inhibit digestion of complex sugars
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Term
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Definition
| Thiazolidinediones (TZDs) |
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Term
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Definition
| Thiazolidinediones (TZDs) |
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Term
| Thiazolidinediones (TZDs) are insulin _______ |
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Definition
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Term
| Rosiglitazone & Pioglitazone (TZDs) MOA: |
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Definition
Bind to nuclear transcription factors involved in insulin action
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Term
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Definition
Increased risk of heart failure, angina, and MI. Contraindicated in Class III-IV heart failure patients.
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Term
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Definition
synthetic amylin analog - injectable agent
"adjunct to insulin therapy" |
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Term
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Definition
Glucagon-like Peptide-1 (GLP-1) analog - injectable agent
"Adjunct to metformin or sulfonylurea or a combination" |
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Term
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Definition
| Newer GLP-1 agonist - injectable agent |
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Term
____ has a 30% greater effect on HbA1C than Exenatide
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Definition
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Term
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Definition
Dipeptidyl Peptidase-4 Inhibitors
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Term
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Definition
Dipeptidyl Peptidase-4 Inhibitors
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