Term
| direct cholinergic agonists |
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Definition
Parasympathomimetic activation
Mimic effects of Ach |
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Term
| indirect cholinergic agonists |
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Definition
prolong cholinergic action by acetylcholinesterases (no destruction of Ach)
Actions: muscarinic, nicotinic, neuromuscular junction, CNS |
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Term
| Anticholinesterases (Irreversible) |
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Definition
Permanantly inactivates acetylcholinesterases via covalent binding
generalized cholinergic activity: paraylsis of motor function, miosis |
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Term
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Definition
Bind to cholinoceptors
Leads to unopposed sympathetic stimulation |
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Term
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Definition
2 types
Ganglion-blocking: block output of ANS
Neuromuscular blocking: motor nerve endings |
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Term
| Nicotonic: Neuromuscular Blocking Drugs |
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Definition
Nicoinic antagonists
2 Types
Antagonists/non depolarizing- block acetylcholine at nicotinic receptor cause flaccid paralysis
Agonits/depolarizing- AFTER muscle fasiculations causes flaccid paralysis
Used during surgery for complete muscle relaxation & for facilitation of intubation |
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Term
| Non-depolarizing Nicotonic: Neuromuscular Blocking Drugs |
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Definition
| Competitive block action of acetylcholine at the end plate of the nicotinic receptor causing flaccid paralysis |
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Term
| Depolarizing Nicotinic: Neuromuscular Clocking Drugs |
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Definition
| Technically a nicotinic agonist, but has neuromuscular blocking properties |
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