Term
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Definition
plan for administration over a period of time
achievement of therapeutic level of the drug in blood without exceeding the minimum toxic concentration |
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Term
| define target plasma level |
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Definition
| guide dosage, able to determine if we can measure effect of the drug |
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Term
| how can you evaluate the effect of a drug that can't be measured |
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Definition
pick a desired target (steady state) plasma level
compute dose to achieve that level
measure plasma levels of the drug
adjust dose as needed to get that level |
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Term
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Definition
| adjust dose so rate of input equals rate of loss, keeps plasma level at target |
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Term
| calculation of maintience dose |
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Definition
Dosing rate Ro = Css x CL/F
F= bioavailability |
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Term
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Definition
| initial dose to get drug to target level, can be a series |
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Term
| calculation of loading dose |
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Definition
| loading dose = Css x Vd/F |
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Term
| what is the steady state, what is the function |
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Definition
| ensures appropirate response to a drug given for long term therapy |
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Term
| how is steady state effected |
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Definition
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Term
| how can you improve steady state |
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Definition
| give the drug more frequently |
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Term
| how is steady state related to half life |
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Definition
double dose has higher steady state so the half life is the same as a lower dose
time to steady state is determine by half life
dose and how often dont help steady state
for every 1/2 life you get 1/2 the way to the goal of steady state
clinical steady state is 4-5 1.2 lives which is close enough to 100% |
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Term
| define therapeutic window and are the parts, define themm too |
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Definition
useful opening between min theraputic concentration and min toxic concentration
through levels: determined by min effective concentration
peak plasma concentration: determine by min toxic concentration |
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Term
| what does a bad kidney do the clearance how do we adjust this |
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Definition
| renal disease or reduced CO reduces clearance |
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Term
| how is clearance calculated |
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Definition
| corrected dose = average dose x (creatine clearance / (100mL/min)) |
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Term
| equation for clearance not inthe kidney |
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Definition
| corrected dose = amt by non renal - amt by kidney x (creatine clearance / (100mL/min)) |
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