Prostaglandin E₁ (PGE₁); smooth muscle relaxing effects

Maintain patency of ductus arteriosus in neonates; erectile dystfunction (injection)

PGF_2α derivative

Eye redness, blurred vision, pigmentation changes (darkening of iris)

glaucoma

PGE₁ derivative; cytoprotective

Diarrhea

Fetal abnormalities

Prevention of NSAID induced gastric ulcers, early abortion, induce labor

Antagonist for CysLT₁ receptor;blocks action of cysteinyl leukotrienes, thus ↓ constriction of airways and inflammation of breathing passages.

asthma

inhibitor of 5-lipoxygenase, and thus inhibits leukotriene formation

sinusitis, nausea, pharyngolaryngeal pain

asthma