ACE inhibitor, blocks conversion of Ang I to Ang II; inhibits degradation of bradykinin, substance P, and enkephalins

Altered taste, angioneurotic edema, dry cough, fetal abnormalities

Hypertension, heart failure and left ventricular dysfunction after MI, delay diabetic nephropathy

Competitive antagonists of angiotensin AT₁ receptors

Fetal abnormalities

Hypertension, heart failure, diabetic nephropathy

Inhibits catalytic activity of renin

Fetotoxicity, angioedema,

hyperkalemia, hypotension

Hypertension

Nonselective antagonist of endothelin ET_A and ET_B receptors; vasodilation

Hypotension, ↑HR, facial flushing or edema, headaches, GI effects
fatal hepatotoxicity, fetotoxicity

Pulmonary arterial hypertension

Selective antagonist of NK₁ receptor (Sub P is ligand of NK₁); blocks CNS effects of Sub P

Fatique, dizziness, diarrhea, CYP interactions

Prevention of chemotherapy-induced nausea and vomiting