Term
| octerotide: duration, type of drug, function, use |
|
Definition
long acting
somatostatin analog
inhibits GH, glucagon, insulin, gastrin
acromeagly, carcinoid |
|
|
Term
| desmopressin: type of drug, MOA, use |
|
Definition
ADH analog
V2 agonist
central diabetes insipidus (ADH replacement) |
|
|
Term
|
Definition
|
|
Term
| what drugs are used for insulin replacement therapy, how |
|
Definition
lispro: mealtime
glargine: basal |
|
|
Term
|
Definition
K channel blocker leads to increased insulin release from B cells
SE: hypoglycemia, weight gain |
|
|
Term
|
Definition
inhibit gluconeogenesis in liver
no hypoglycemia or weight gain
SE: rare lactic acidosis in pt with renal dysfunction because drug accumulates |
|
|
Term
|
Definition
insulin sensitizer: stimulate PPARy receptors which increase number of insulin receptors on many organs (like skeletal M)
edema, weight gain |
|
|
Term
| what diabetes drugs target pancreas, MOA |
|
Definition
GLP-1 is an incretin that causes insulin release
exenatide is a GLP-1 analog
incretins are metabolized to inactive by DPP-4
sitaglipdin is a DPP-4 antagonist |
|
|
Term
|
Definition
T4 agonist needs to be converted to T3
hypothyroid |
|
|
Term
| methinizaole: MOA, SE, use |
|
Definition
blocks all the steps in thyroid hormone synthesis
iodide conversion to iodine via thyroid peroxidase
peroxidase conversion to MIT/DIT making T3/4
SE: agranulocytosis
TX: hyperthyroid |
|
|
Term
|
Definition
thyroid sucks it up and B radiation destories thyroid
TX hyperthyroid
not for pregnant and kids |
|
|
Term
| explain the glucocordicoud/mineral corticoid activity of the three steroids |
|
Definition
hydrocortizone: 1:1
dexamethasone: 1:0
flucortizone: 10:250 |
|
|
Term
|
Definition
adrenal insufficiency
congenital adrenal hypothyroid
after cushing surgery |
|
|
Term
|
Definition
aldosterone: Na/water retention, edema, increased BP
glucacorticoid: cushing like, ulcers |
|
|
Term
| use of conjugated equine estrogen |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
oral contracepitive
hormone replacement |
|
|
Term
|
Definition
progesterone receptor blocker
abortion (when added with prostaglandins) |
|
|
Term
|
Definition
5a reductase inhibitor stops testosterone conversion to DHT
BPH, balding |
|
|
Term
| when can't you use finastride |
|
Definition
a1 blocker and a1A blocker both treat BPH
if pt needs to lower BP then don;t choose finasteride |
|
|
Term
|
Definition
androgen receptor blocker (used with GNRH agonist continous administration(
prostate cancer |
|
|
Term
|
Definition
PDE3 inhibitor increases cAMP: relaxes, vasodilates, increases blood flow
erectile dysfunction |
|
|
Term
|
Definition
dont take with nitrates or a blockers (which are also vasodilators and cause orthostatic hypotension)
hypotension
PDE6 inhibition causes blue green color blidness |
|
|
Term
|
Definition
| hypocalcemia (tetany, M spasms) |
|
|
Term
|
Definition
1,25-dihydroxy vitamin D in active form
rickets, osteomalacia, osteoperosis |
|
|
Term
| alendronate: MOA, use, SE |
|
Definition
decrease bone reabsorption
TX: osteoperosis DOC, pagets disease
SE: esophageal irritation (stay upright after taking) |
|
|
Term
|
Definition
selective estrogen receptor modulator, agonist on bone, antagonist on breast and uterus
antagonist at uterus DOES NOT give increased risk of endometrial cancer (like tamoxifin)
TX: osteoperosis, breast cancer |
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