Cimetidine

Ranitidine

Famotidine

Nizatidine

Peptic ulcer disease, GERD, erosive esophagitis, gastric acid hypersecretion

Necrotizing enterocolitis in fetus or newborn, agranulocytosis, psychotic disorder, headache, dizziness, arthralgia, myalgia, constipation, diarrhea, gynecomastia, galactorrhea, loss of libido

Hypersensitivity and Pregnancy

Inhibitis the cytochrome P450-mediated metabolism of certain drugs

peptics ulcer disease, GERD, erosive esophagitis, gastric acid hypersecretion

Necrotizing enterocolitis in fetus or newborn, pancreatitis, headache, dizziness, arthralgia, myalgia, constipation, diarrhea

hypersensitivity

Ranitidine can be given IV to traet hypersecretory conditions or to treat patients who are not able to tolerate the oral formulation.

Bioavailability of nizatidine is higher than that of other H2 receptor antagonists. Nizatidine is removed by kidneys.

Omeprazole

Esomeprazole

Lansoprazole

Dexlansoprazole

Pantoprazole

Rabeprazole

Peptic ulcer disease, GERD, erosive esophagitis, gastric acid hypersecretion, H. pylori gastrointestinal tract infection, healing of damage done by NSAIDs, Zollinger-Ellison Syndrome

Pancreatitis, hepatotoxicity, interstital nephritis, possible interference with antiplatelet effects of clopidogrel, possible increased risk of hip, wrist, and spine fracture, hospital-acquired pneumonia and enteric infections including C. diff, salmonella, and e. coli, headache, diarrhea, rash, GI discomfort, anorexia, asthenia, back pain

Hypersensitivity

PPIs are metabolized in the liver by CYP2C19 and CYP3A4. Increased Gastrin secretion.

Aluminum hydroxide

Magnesium hydroxide

Sodium bicarbonate

Calcium carbonate

Symptomatic relief of dyspepsia associated with peptic ulcer disease, gastritis, GERD, or hiatal hernia

Phosphate depletion (severe weakness, malaise, anorexia), constipation, osteomalacia in patients with renal failure

Hypersensitivity

All antacids can potentially increase or decrease the rate or extent of absorption of concurrently administered oral drugs by changing transit time or by binding the drug. Use with Magnesium hydroxide eliminates constipation.

Symptomatic relief of dyspepsia associated with peptic ulcer disease, gastritis, GERD, or hiatal hernia

Diarrhea, hypermagnesemia (in patients with renal failure)

hypersensitivity

All antacids can potentially increase or decrease the rate or extent of absorption of concurrently administered oral drugs by changing transit time or by binding the drug. Use with Aluminum hydroxide stops diarrhea.

Symptomatic relief of dyspepsia, metabolic acidosis, urinary alkalinization, uric acid renal stones, diarrhea

abdominal cramps, flatulence, alkalosis, vomiting

respiratory alkalosis, hypocalcemia, hypochloremia

All antacids can potentially increase or decrease the rate or extent of absorption of concurrently administered oral drugs by changing transit time or by binding the drug. In addition, significant sodium retention in patients with hypertension or fluid overload. Sodium bicarbonate + HCl = H20, C02, Salt

Symptomatic relieft of dyspepsia, osteoporosis

Hypercalcemia, nausea, vomiting, anorexia, constipation

severe renal insufficiency

All antacids can potentially increase or decrease the rate or extent of absorption of concurrently administered oral drugs by changing transit time or by binding the drug. In addition, hypercalcemia can occur in patients with impaired renal function.

Sucralfate

Colloidal bismuth

Peptic ulcer disease, Gastric ulcer disease, GERD

Aluminum accumulation and toxicity (especially in patients with renal impairment) constipation

hypersensitivity

Decreased effectiveness of quinolones (e.g. ciprofloxacin) because of chelation and decreased absorption

Peptic ulcer disease, gastric ulcer disease, GERD, Diarrhea with associated abdominal craps, H. pylori infection

darkening of the tongue and/or stool, anusea, vomiting

Kown allergy to aspirin or other nonaspirin salicylates

Frequently used as a component of a multidrug regimen for eradication of H. pylori because bismuth impedes growth of the organism. Reduces absorption of tetracyclines, likely through chelation or by reducing solubility as a result of increasing gastric pH. Acute bismuth intoxication is manifested by gastrointestinal disturbance, stomatitis, discoloration of mucous membranes, and potential for kidney and liver damage.

NSAID ulcers

could give you a tummy ache and the runs

Irritable bowel syndrome, peptic ulcer disease

dry mouth, blurred vision, tachycardia, urinary retention, constipation

age less than 6 months, breastfeeding, GI obstruction, glaucoma, myasthenia gravis, obstructive uropathy, reflux esophagitis, severe ulcerative colitis or toxic megacolon

Not as effective as H2 receptor antagonists or proton pump inhibitors for the treatment of peptic ulcer disease