Term
| Inhibitors of Thymidylate Synthase |
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Definition
| Decrease dTMP. Fluorouracil (5-FU), Capecitabine, Pemetrexed |
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Term
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Definition
| Breast Cancer, GI cancers, Skin cancer (topical) {Coronary atherosclerosis, thrombophlebitis, GI ulcer, Myelosuppression, cerebellar syndrome, visual changes, lacrimal stenosis} [Bone marrow depression, poor nutrition, infection, dihydropyrimidine dehydrogenase deficiency, pregnancy] Suicide inhibitor. Drug metabolite FUTP interferes with protein synthesis. Folinic acid potentiates action. |
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Term
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Definition
| Metastatic colorectal cancer, breast cancer {same as fluorouracil} [dihydropyrimidine dehydrogenase dificiency, renal failure] prodrug of 5-FU |
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Term
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Definition
| Non-small cell lung cancer, Mesotheliuma (w/ cisplatin) {Myelosuppression, angina, MI, stroke, thrombophlebitis, liver damage, bulla, fatigue, nausea, vomiting, diarrhea, stomatitis} [Hypersensitivity, renal impairment] Folate analogue. Inhibits methylenetetrahydrofolate site. Folic acid and B12 coadministered. |
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Term
| Purine Metabolism Inhibitors |
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Definition
| 6-Mercaptopurine (6-MP), Azathioprine, Pentostatin |
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Term
| Purine Metabolism Inhibitor MOA |
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Definition
| Inhibit IMPDH and other enzymes that synthesize AMP/GMP |
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Term
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Definition
| Acute lymphoid leukemia, acute myeloid leukemia, Crohn's {Pancreatitis, myelosuppression, hepatotoxicity, infection, gastritis} [Pregnancy] Effects increased by allopurinol |
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Term
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Definition
| Immunosuppression in renal transplantation, rheumatoid arthritis, inflammatory bowel disease {Pancreatitis, myelosuppression, hepatotoxicity, infection, gastritis} [Pregnancy] Less toxic 6-MP prodrug. Used for autoimmune diseases |
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Term
| Ribonucleotide Reductase Inhibitors |
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Definition
| Thioguanine, Fludarabine phosphate, Cladribine, Cytarabine (araC), Azacytidine, Gemcitabine |
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Term
| Ribonucleotide Reductase Inihibtor MOA |
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Definition
| Inihibition of DNA polymerase causing cell death |
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Term
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Definition
| Acute Myelocytic Leukemia {Myelosuppression, hyperuricemia, intestinal perforation, hepatotoxicity, infection GI disturbance} [Thioguanine/mercaptopurine resistance] Guanine analogue |
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Term
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Definition
| B-cell chronic lymphocytic leukemia, Non-Hodgkin's {aplasia of skin, autoimmune hemolytic anemia, myelosuppression, neurotoxicity, pneumonia, infection, edema, GI disturbance, asthenia, fatigue} [Hypersensitivity] Purine neucleotide analogue |
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Term
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Definition
| Hairy cell leukemia, MS {Febrile neutropenia, myelosuppression, neurotoxicity, infection, rash, injection site reaction, nausea, headache} [Hypersensitivity] Purine analogue |
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Term
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Definition
| ALL, AML, CML, Meningeal leukemia, Hodgkin's disease, Non-Hodgkin's {Myelosuppression, neuropathy, nephrotoxicity, liver dysfunction, infection, thrombophlebitis, rash, hyperuricemia, GI disturbance, ulsers of mouth or anus} [Hypersensitivity] Cytidine analogue |
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Term
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Definition
| Myelodysplastic syndrome {Myelosuppression, renal failure, peripheral edema, Gi disturbance, hepatic coma, lethargy, cough fever} [Advanced malignant hepatic tumors] Cytidine analogue |
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Term
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Definition
| Pancreatic cancer, Non-small cell lung cancer, Breast/Ovarian/Bladder cancers, Sarcoma, Hodgkin's disease {Myelosuppression, febrile, neutropenia, pulmonary toxicity, hepatotoxicity, hemolytic uremic syndrome, fever, GI disturbance, liver enzyme elevation, edema, rash, paresthesias} [Hypersensitivity, pregnancy] Cytidine analogue |
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Term
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Definition
| Cyclophosphamide, Mechlorethamine, Melphalan, Estramustine, Chlorambucil, Mitomycin, Thiotepa, Carmustine, Dacarbazine, Procarbazine, Altretamine |
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Term
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Definition
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Term
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Definition
| Autoimmunity, Leukemias/lymphomas, mycosis fungoides, neuroblastoma, ovarian cancer, retinoblastoma, breast cancer, malignant histiocytosis {Cyclophosphamide Adversia} [Severely depressed bone marrow} A metabolite (acrolein) causes hemorrhagic cystitis prevented with mesna coadministration |
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Term
| Cyclophosphamide Adversia |
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Definition
| {Myelosuppression, cardiomyopathy, Stevens-Johnson, hemorrhagic cystitis, azoospermia, interstitial pneumonia, infection, alopecia, GI disturbance, leukopenia, amenorrhea} |
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Term
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Definition
| Leukemia and Hodgkin's disease {cyclophosphamide adversia} [infection] |
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Term
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Definition
| Lymphoma {cyclophosphamide adversia} |
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Term
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Definition
| Prostate cancer {cyclophosphamide adversia} [Active thrombophlebitis or thromboembolic disorder] |
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Term
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Definition
| Leukemia {cyclophosphamide adversia} |
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Term
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Definition
| Gastric and pancreatic cancer {cyclophosphamide adversia} [Coafulation disorder, renal impairment] |
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Term
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Definition
| Bladder cancer {cyclophosphamide adversia} [Hepatic, renal or bone marrow dysfunction] Instilled directly into the bladder |
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Term
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Definition
| Brain Cancer {cyclophosphamide adversia} A nitrosurea that attaches a carbamoyl group to target proteins |
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Term
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Definition
| Hodgkin's disease {cyclophosphamide adversia} |
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Term
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Definition
| Hodgkin's disease {cyclophosphamide adversia} [Severe bone marrow depression] |
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Term
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Definition
| Ovarian cancer {cyclophosphamide adversia} [Severe bone marrow depression, severe neurologic toxicity] |
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Term
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Definition
| Cisplatin, carboplatin, oxaliplatin |
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Term
| Platinum DNA Modifier MOA |
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Definition
| Crosslink intrastrand guanine bases |
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Term
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Definition
| Genitourinary/Lung cancers {Nephrotoxicity (cisplatin) myelosuppression, peripheral neuropathy, ototoxicity, electrolyte imbalance} [Severe bone marrow depression, renal or hearing impairment] Cisplatin injected for ovarian. Amifostine coadministration with cisplatin limits nephrotoxicity |
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Term
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Definition
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Term
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Definition
| Binds oxygen and chelates Fe2+, breaks DNa strands via oxidative intermediates |
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Term
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Definition
| Testicular cancer, Hodgkin's disease, Non-Hodgkin's, Squamous cell carcinoma {Pulmonary fibrosis, vascular disease, MI, Stroke, Raynauds, Hepatotoxicity, nephrotoxicity, myelosuppression, alopecia, rash, hyperpigmentation, skin tenderness, GI disturbance, stomatitis} [Hypersensitivity] Dose-limiting, irreversible pulmonary function effects. |
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Term
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Definition
| Irinotecan, Topotecan, Doxorubicin, Daunorubicin, Epirubicin, Etoposide, Teniposide, Amasacrine |
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Term
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Definition
| Colorectal Cancer {severe diarrhea, myelosuppression, febrile neutropenia, liver dysfunction, interstitial lung disease, alopecia, eosinophilia} ]Severe bone marrow depression] Camptothecin that inhibits topoisomerase I, specific to S phase |
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Term
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Definition
| Small cell lung cancer, cervical carcinoma, ovarian cancer {severe diarrhea, myelosuppression, febrile neutropenia, liver dysfunction, interstitial lung disease, alopecia, eosinophilia} ]Severe bone marrow depression] Camptothecin that inhibits topoisomerase I, specific to S phase |
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Term
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Definition
| {Heart failure, myelosuppression, alopecia, rash, GI disturbance} [Pre-existing heart failure, severe bone marrow depression] |
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Term
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Definition
| Leukemias, lymphomas, breast cancer, bladder caner, thyroid cancer, GI cancer, nephroblastoma, osteosarcoma, ovarian cancer, small cell carcinoma, soft tissue sarcoma {Doxorubicin adversia} Anthracycline for topoisomerase II. G2 phase. |
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Term
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Definition
| ALL, AML {Doxorubicin adversia} Anthracycline for topoisomerase II. G2 phase. |
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Term
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Definition
| Breast Cancer {Doxorubicin Adversia} [Plus severe hepatic dysfunction] Anthracycline for topoisomerase II. G2 phase. |
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Term
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Definition
| Testicular/lung cancer {Doxorubicin adversia} [Hypersensitivity] epipodophyllotixin that inhibits topoisomerase II. Last S and G2 phases |
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Term
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Definition
| ALL, non-hodgkin's {Doxorubicin adversia} [Hypersensitivity] epipodophyllotixin that inhibits topoisomerase II. Last S and G2 phases |
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Term
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Definition
| Recurrent leukemia, ovarian cancer {ECG changes with QT prolongation, paralytic ileus, myelosuppression, convulsion, azoospermia, hepatotoxicity, alopecia, GI disturbance} [Hypersensitivity] topoisomerase II |
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Term
| Microtubule Polymerization Inhibitors |
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Definition
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Term
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Definition
| Metastatic testicular/breast cancers, lymphoma, AIDS-related Kaposi, Choriocarcinoma, Malignant histiocytosis, Mycosis fungoides {Myelosuppression, HTN, neurotoxicity, azoospermia, alopecia, bone pain, GI disturbance} [Bacterial infection, granulocytopenia] Bone marrow suppression is dose limiting |
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Term
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Definition
| Leukemias, hodgkin's disease, Non-Hodgkin's, Rhabdomyosarcoma, Nephroblastoma {Peripheral neuropathy, myopathy, myelosuppression, alopecia, GI disturbance, diplopia} [Carcot-Marie-Tooth, Intrathecal use] Peripheral neuropathy is dose-limiting |
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Term
| Microtubule Depolymerization Inhibitors |
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Definition
| Paclitaxel, Albumin-bound paclitaxel, Docetaxel |
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Term
| Paclitaxel and Albumin-bound paclitaxel |
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Definition
| Ovarian/Breast cancer, Non-small cell lung cancer, AIDS-related Kaposi {Myelosuppression, pulmonary toxicity, severe hypersensitivity reaction, myopathy, peripheral neuropathy, alopecia, GI disturbance, arthralgia} [Neutropenia] Peripheral neuropathy is dose limiting |
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Term
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Definition
| Breat/Prostate/Gastric cancers, Non-small cell lung cancer {Myelosuppression, Stevens-Johnson, fluid retention syndrome, edema, neuropathy, hepatotoxicity, colitis, alopecia, GI disturbance, asthenia, fever} [neutropenia] Myelosuppression is dose-limiting |
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