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PHAR 434
Dr. Jo's stuff
28
Science
Professional
05/07/2009

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Term
T/F Drugs are generally less well distributed to poorly perfused tissues compared with highly perfused tissues
Definition
True
Term
T/F When graphed, non-linear pharmacokinetics are characterized by data that exhibits a straight line only when plotted as log-log functions.
Definition
False
Term
T/F Formation clearance (Clp->mX) is a non-linear pharmacokinetic parameter that provides a meaningful estimate of the portion of the total body clearance that is accounted for by production of a specific metabolite
Definition
True
Term
T/F Biopharmaceutics is defined as the study of the relationship between the nature and intensity of a drug's effects and various drug formulation or administration factors.
Definition
True
Term
Heart failure reduces cardiac output and hepatic blood flow. Consequently, the total daily dose of lidocaine may need to be decreased in a patient with heart failure who has a myocardial infarction.
Definition
True
Term
T/F If drug A is absorbed at a faster rate than another similar drug B, drug A may produce a higher peak concentration but delayed onset of action than drug B.
Definition
False
Term
For most drugs, when clearance is decreased but volume of distribution is unchanged, the dosing interval and the dose should be similar to that in healthy person.
Definition
False
Term
T/F First-pass effect is removal of drug by the liver after absorption but before reaching systemic circulation.
Definition
True
Term
The portion of drug that is NOT bound to plasma protein is pharmacologically active but can not well distribute into tissues.
Definition
False
Term
T/F Assay cross-reactivity refers to diminished assay performance by structurally related drug compounds or metabolites for which the assay method measures as if they were the desired assay compound.
Definition
True
Term
If drug A follows dose-dependent (non-linear) elimination and Km = 20mg/L. Assume that a single IV dose of 100mg achieves an initial plasma concentration of 40mg/L - Describe the type of plasma drug concentration vs. time curve that is likely to be observed at the 100 mg dose of drug A.
Definition
If log C is plotted against time, the graphed line will be curved at the top and become a straight line when plasma concentration = Km.
Term
T/F Active transport moves drug molecules against a concentration gradient.
Definition
True
Term
T/F Active transport follow's Fick's law of diffusion.
Definition
False
Term
T/F Active transport requires energy.
Definition
True
Term
T/F Active transport of drug molecules may be saturated at high drug concentrations.
Definition
True
Term
Define the term prodrug.
Definition
A prodrug is a drug that becomes active after biotransformation.
Term
Is hydrolysis a Phase I or a Phase II reaction?
Definition
Phase I
Term
Describe the term "bioavailability."
Definition
A measurement of the rate and extent of drug that reaches the systemic circulation.
Term
If drug A goes from being 80% bound to plasma albumin to being 90% bound. Assuming that plasma volume (Vp), volume of tissue (Vt), and free fraction in the tissue (Ft) does not change, how will the volume of distribution (V) change?
Definition
V will decrease
Term
The biological half-life of many drugs in often prolonged in neonates because of ?
Definition
incompletely developed enzyme systems
Term
Since aminoglycosides are inactivated by penicillins, what is/are the proper way(s) to handle the plasma sample after it is drawn?
Definition
Either freeze the sample until it can be analyzed OR immediately analyze the sample.
Term
Cationic drugs and weak bases are more likely to bind to
Definition
Alpha-1-acid glycoprotein.
Term
Anionic drugs are more likely to bind to
Definition
albumin
Term
Lipophilic drugs are more likely to bind to
Definition
lipoproteins
Term
What is a drawback of model independent relationships?
Definition
they cannot be used to predict plasma concentration versus time profiles
Term
T/F Model independent relationships can be used to predict plasma concentration versus time profiles
Definition
False
Term
What are the 2 most important pharmacokinetic parameters?
Definition
total body clearance and apparent volume of distribution
Term
What is the term used to express bioavailability?
Definition
F (a number less than or equal to 1 that indicates the fraction of drug reaching the systemic circulation)
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