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Pentose Phosphate Pathway
EXAM 2
19
Medical
Professional
08/29/2010

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Cards

Term
where does the pentose pathway occur?
Definition
cytosol
Term
what does the pentose pathway breakdown
Definition
glucose 1,6 phosphate
Term
for each molecule entering the oxidative pathway, what is produced
Definition
CO2 and 2 NADH
Term
what is the alternate product of glycolysis being oxidized?
Definition
ribose 5-phosphate
Term
what is the purpose of the pentose phosphate pathway
Definition
regeneration of NADH
Term
how do erythrocytes require NADH
Definition
regeneration of reduced glutathione for protection from oxidative damage
Term
which pathway is the major site of regulation in the pentose pathway
Definition
oxidative
Term
what is produced during the oxidative pathway?
Definition
NADH and ribose 5 phosphate
Term
a deficiency in g6p causes what?
Definition
hemolytic anemia
Term
what does the non oxidative pathway permit?
Definition
rib 5 p to be converted to ribose 5 phosphate or to intermediates of glycolysis.
Term
what are the intermediate of glycoloysis produced by the non oxidative pathway?
Definition
Term
how is the pentose phosphate pathway regulated?
Definition
the levels of NADP
Term
what does the flow of g 6 p depend on?
Definition
NADH, ribose 5 phosphate and ATP.
Term
This is required in rapidly dividing cells?
Definition
higher amounts of ribose 5 phosphate
Term
what role does NADPH production play in g6p deficiency?
Definition
Term
what effect does peroxide play on causing hemolytic anemia?
Definition
detoxification is inhbited leading to cellular damage
Term
what is the effect of excess peroxide near the membrane
Definition
lipid peroxidation
Term
this reduces hydrogen peroxide to harmless water
Definition
glutathione
Term
what is required to make reactive oxygen species in phagocytes
Definition
NADPH
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