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PDA 2 Exam 1
Drugs for exam 1
60
Biology
Professional
01/31/2009

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Term
Vigabatrin
Definition
Inhibits GABA transeminase enzyme. Inhibits seizures
Term
Muscimol
Definition
GABA A agonist. Increase Cl- in the cell. Shrooms
Term
Picrotoxin
Definition
GABA A antagonist. Pro convulsant. Dec opening of Cl- channels
Term
Baclofen
Definition
GABA B agonist. Reduces Ca2+ influs, increases K+ efflux, reduce spasticity
Term
Strychnine
Definition
Glycine antagonist. Doesn't allow influx of Cl- causing seizures from lack of basal firing
Term
Diazepam
Definition
Benzodiazepine. Used for Anti-anxiety, long lasting hypnotic, anticonvulsant,
Term
Alprazolam
Definition
Benzodiazepine. Anti-anxiety medication for panic disorders
Term
Flurazepam
Definition
Benzodiazepine. Long lasting hypnotic
Term
Temazepam
Definition
Benzodiazepine, intermediate lasting hypnotic, causes amnesia
Term
Triazolam
Definition
Benzodiazepine, short acting hypnotic
Term
Clonazepam
Definition
Benzodiazapine, anti convulsant,
Term
Buspirone
Definition
Treats anxiety, Partial agonist on 5-HT1A receptor (GPCR), slow onset (week), minimal sedation and no anti-convulsant, lower SE= less problematic
Term
Flumazenil
Definition
Benzodiazepine, used to treat overdose, can induce withdraw in dependant patients. Can antagonize actions of zolpidem
Term
Phenoarbital
Definition
Barbituate, lasts for hours
Term
Pentobarbital
Definition
Barbituate, lasts for hours
Term
Thiopental
Definition
Barbituate, acts w/in a couple seconds and lasts 30min. truth serum
Term
Paroxetine
Definition
Anti-anzxiety, SSRI
Term
Venlafaxine XR
Definition
Anti-anxiety, inc both NE and Seretonin
Term
Zolpidem
Definition
Hypnotic, short term treatment for insomnia, non benzo (same action but different chemical shape) binds to same location as Benzo (BZalpha1) on GABA A. No rebound insomnia. Only use 7 to 10 days.
Term
Eszopiclone
Definition
Short acting non-benzo hypnotic. It's a Cyclopyrrolone. Safe in children and elderly
Term
Ramelteon
Definition
Melatonin 1 and 2 receptor agonist. treats insomnia. NOT a controlled substance like zolpidem and most other benzos are
Term
Hydroxyzine
Definition
antihistimine. antiemetic. competes with histimine for the H1 receptor. Given to patients with history of drug abuse. treats anxiety
Term
Chloral Hydrate
Definition
Sedative, hypnotic. can cause GI stress
Term
Ethanol
Definition
Hypnotic, self treatment, also anti anxiety uses
Term
Atomoxetine (strattera)
Definition
Selective NE reuptake inhibitor at pre synaptic cleft used to treat ADHD in children
Term
Cocaine
Definition
inhibits NET, DAT, and 5-HT reuptake. inc . amts of NT in brain inc. nirvana and hallucinations
Term
Ondansetron
Definition
5-HT3 receptor antagonist. prevents/treats vomitint in chemo patients
Term
Galantamine (Razadyne)
Definition
Cholinesterase inhibiter (anticholinesterase) inc. amt of Ach, used to treat AD, can act as muscarinic and nicotinic antagonist
Term
Rivastigmine (exelon)
Definition
cholinesterase inhibitor used to treat AD (anticholinesterase, inch Ach)
Term
Donepezil (aricept)
Definition
Cholinesterase inhibitor (anticholinesterase, inch Ach) used to treat AD
Term
Memantine (Namenda)
Definition
NMDA antagonist, treat moderate to sever AD, help pt. stay somewhat independant for a little longer. Can be used with cholinesterase inhibitors
Term
Levodopa
Definition
Dopamine replacement drug used to treat PD. It's the metabolic precursor for DA and bypasses the rate limiting step when administered as L-dopa. it's heavily metabolized
Term
Cabidopa
Definition
Dopamine Decarboxylase inhibitor, Doesn't cross BBB so allows L-dopa to not be metabolized. inhib dopa decarboxylase in the periphery nervous system allowing for increased synthesis of dopamine in the CNS. Can give lower doses of L-dopa with Carbidopa so less Side effects. treats PD
Term
Sinemet
Definition
Levodopa-carbidopa combination. Increases DA, treats PD
Term
Bromocriptine
Definition
D2 dopamine receptor agonist, mimics DA action, little response with patients who didn't respond to L-dopa. Treats PD
Term
Pergolide
Definition
D1/D2 agonist, mimics DA action. treats PD
Term
Amantadine
Definition
antiviral drug used to treat PD. Less potent than L-dopa so fewer side effects
Term
Selegiline (L-deprenyl)
Definition
MAO B inhib. treats PD
Term
Entacapone
Definition
Treats PD, COMT inhibitor. Reduces breakdown of DA from L-dopa
Term
Stalevo
Definition
Combo of L-dopa, Carbidopa and Entacapone. treats PD
Term
Benztropine
Definition
MAchR antagonist, treats PD for ppl w/antipsychotic drugs.
Term
Trihexyphenidyl
Definition
MAchR antagoinist. treats PD for ppl w/antipsychotic drugs
Term
Haloperidol
Definition
Antipsychotic dopamine antagonist used to treat HD
Term
Prednisolone
Definition
corticosteroid, treats MS, dec immune system antibody production which reduces meylin swelling and inflammation
Term
Interferon-beta
Definition
Protein fights virus, treats MA, regulates immune system. very expensive b/c they have to isolate the isomer
Term
Glatiramer acetate (copaxone)
Definition
non interferon, non steroidal, reduces new brain leisons, treats MS, change t-cells from bad to good
Term
Mitoxantrone (Novantrone)
Definition
antineoplastic cancer drug, treats MS, suppresses activity of T-cells, B-cells, and macrophages
Term
Halothane
Definition
Potent inhailed anesthetic, weak analgesic, can cause malignant hyperthermia. metabolized in the liver
Term
Dantrolene
Definition
antidote to malignant hyperthermia. neuromuscular blocker. blocks Ca2+ channels
Term
Enflurane
Definition
Inhailed anesthetic, less potent and toxic than Halothane therefore less induction and recovery time. can cause seizures and malignant hyperthermia
Term
Isoflurane
Definition
inhailed anesthetic. less potent than halothane and even enflurane so less induction and recovery time. less toxic and fewer side effects so most widely used
Term
Nitrous Oxide
Definition
Inhailed anesthetic, LOW blood:gas coefficient so very rapid induction and recovery. weak anesthetic but strong analgesic. often given with something else. can cause apoxia or oxygen uptake retardation in peopel with respiratory problems. can depress bone marrow production if given too long or longer than 6 hours
Term
Thiopental
Definition
Barbiturate IV anesthetic, used as induction agent b/c very lipid soluble but short acting. poor analgesic
Term
Etomidate
Definition
Non-barbiturate IV anesthetic, acts through GABA A, induction agent,
Term
Propofol
Definition
IV anesthetic, rapidly metabolized= rapid recovery. poor analgesia, used for induction
Term
Ketamine
Definition
Non-barbiturate IV anesthetic, short acting, provides dissociative anesthesia, patient may look awake but isn't used mostly in children b/c gives adults hallucinations
Term
Succinylcholine
Definition
muscle relaxant, facilitates intubation, depolarizing neuromuscular blocking drug.
Term
Lidocane
Definition
Local anesthetic. also used for cardiac arrythmeas
Term
Procaine
Definition
Local anesthetic
Term
Bupivicaine
Definition
Local anesthetic
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