Term
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Definition
Most common and smallest of all immunoglobulins.
Major component in secondary immune response.
Goes across placenta.
Monomer |
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Term
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Definition
Largest of all immuoglobulins. Pentamer.
Found in serum.
***Initial responder in primary immune response***
IGM is present when patient is Miserable |
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Term
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Definition
very limited info
found in blood
found on surface on B cells where they function as b-cell antigen recptors |
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Term
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Definition
| response to antigen involving B Cells to produce antibodies, IgG, IgM, IgA, IgD, IgE |
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Term
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Definition
Least Abundant
Antigen receptors on B cells |
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Term
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Definition
Mucosal
Found in Breastmilk |
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Term
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Definition
T Lymphosites attack the antigen directly
Antigen presenting Cells
Memory cells - induce secondary immune response.
Lymphokine producing cells -> produce cytokines that induce macrophages.
Cytotoxic T cells - attack cells directly and destroys cells with foreign antigens.
CD4 (T-helper cells)- Regulatory, control Humoral and cell mediated response,
**Humoral and cell Mediated work together** |
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Term
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Definition
Glycoprotein
Found in all cells except RBC
Like an ID bracelet or code used to distinguish self from non-self.
All Cells have different codes. |
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Term
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Definition
T-cell functions decrease (cell mediated)
There are the same number but the function decreases.
Delayed hypersensitivity decreases.
Circulating auto antibodies and immune complexes increase. |
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Term
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Definition
Type I- IgE mediated rxn: Allergic rxn, atopic dermatitis, asthma. Increased IgE
Type II - Tissue specific, 5 general mechanisms:
1) Cell may be destroyed by antibodies IgG or IgM attack ie Hemolytic Anemia.
2) Macrophages - Phagocytosis
3) Toxins produced by neutophils
4) ADCC Natural killer cells are destroyed.
5) Cell is not destroyed but malfunctions ie: Graves disease Myesthenia Gravis, graft/tissue rejection.
Type III - Immune complex Mediated, not tissue specific. ie: Serum Sickness, Glomeral nephrosis, Rhumatic fever, heart disease.
Type IV- Cell Mediated - ***only type of hypersensitivity that does not include antibodies. delayed response, may take 3-5 days to produce. ie: Poison ivy - urushiol- Hapton that binds with larger skin molecule - reacts with normal skin protein. |
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Term
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Definition
The immune system recognizes self as non self ie:
System Lupus - Type II and III hypersensitivity. involves all body systems.
More women than men.
More blacks than whites.
S/S Malor rash, discord rash, photosensitivity, arthritis, serosis, renal disorders, neuro disorder, Hematologic disorder. |
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Term
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Definition
One individual immune system produced and immune response to anther individual.
**Isoimmunity
Type II hypersensitivity mech 1
ie: Rh incompatibility, blood transfusion rxn |
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Term
| bacterial protective mechanisms |
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Definition
Encapsulate: TB, Strep and Pneumonia
Exotoxins: TDap vaccines stop bacteria from producing exotoxins (protein byproducts from bacteria that damage cell membranes.)
Endotoxins: Gram negative bacteria, endotoxins are released from cell membrane when cell is destroyed or during treatment with antibiotics. Endotoxins are Pyrogenic- induce fever and activate an inflammatory response. |
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Term
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Definition
| No metabolism, must rely on host cell to reproduce |
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Term
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Definition
Polio and Parainfluensa
replicates in the cytoplasm of the infected host cell. |
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Term
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Definition
Hep B and Herpes
Requires the DNA Polyemerase of the host cell to replicate. The virus enters the nucleus of the cell. |
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Term
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Definition
HIV
Converts viral RNA to vital DNA using reverse transcriptinase in the host cell. |
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