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Pathophysiology
Respiratory Infections and Lung Cancer
49
Biology
Undergraduate 2
03/22/2012

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Term
RESPIRATORY TRACT INFECTIONS:
Definition
CAN INVOLVE UPPER RESPIRATORY TRACT, LOWER RESPIRATORY TRACT OR BOTH.
Term
RESPIRATORY TRACT INFECTIONS:
UPPER
Definition
-NOSE
-OROPHARYNX
-LARYNX
Term
RESPIRATORY TRACT INFECTIONS:
LOWER
Definition
-TRACHEA
-BRONCHIAL TREE
-LUNGS
Term
RESPIRATORY TRACT INFECTIONS:
MANIFESTATIONS
Definition
-COMMON COLD
-RHINOSINUSITIS
-INFLUENZA
-PNEUMONIS
-TUBERCULOSIS
Term
RESPIRATORY TRACT INFECTIONS:
UPPER (ADULTS)
Definition
-COMMON COLD
-RHINOSINUSITIS
-INFLUENZA
Term
RESPIRATORY TRACT INFECTIONS:
COMMON COLD FACTS
Definition
-VIRAL INFECTION OF UPPER RESPIRATORY TRACT
-MOST COMMON R.T. INFECTION
-ADULTS HAVE 2-4 COLDS/YEAR
-SCHOOLCHILDREN HAVE UP TO 10 COLDS/YEAR
-SELF LIMITING, LASTS ABOUT 7 DAYS
Term
RESPIRATORY TRACT INFECTIONS:
COMMON COLD SYMPTOMS
Definition
-DRYNESS AND STUFFINESS IN NASOPHARYNX
-NASAL SECRETIONS, TEARS
-MUCUS MEMBRANES RED, SWOLLEN, SECRETE MUCUS
-SORE THROAT, HOARSENESS
-HEADACHE, GENERAL MALAISE
-CHILLS, FEVER, EXHAUSTION
Term
RESPIRATORY TRACT INFECTIONS:
COMMON COLD VIRUSES
Definition
-SEASON, AGE, PRIOR EXPOSURE DETERMINE TYPE OF VIRUS CAUSING COMMON COLD
-RHINOVIRUSES; COMMON IN SPRING AND FALL, MOST COMMON COLD VIRUS BETWEEN 5AND 40 YRS OLD.
-OTHER VIRUSES CAUSE WINTER AND SPRING COLDS
-OVER 100 SEROTYPES OF RHINOVIRUS
-IMMUNITY ACQUIRED TO A SPECIFIC SEROTYPE OF RHINOVIRUS.
Term
RESPIRATORY TRACT INFECTIONS:
ENTRY OF COLD VIRUS
Definition
-CHILDREN SPREAD
-COUGHING AND SNEEZING SPREAD
-VIRUS CAN LIVE 5 HRS ON SURFACES
-MOST COMMON ENTRY PORTALS EYES, NOSE
-FINGERS PICK UP,TRANSFER TO EYES, NOSE
-HAND WASHING PREVENTS INFECTION
-INHALATION LESS IMPORTANT THAN FINGERS IN SPREAD
-ANTIBIOTICS INEFFECTIVE IN TREATMENT OF COLD
Term
RESPIRATORY TRACT INFECTIONS:
RHINOSINUSITIS
Definition
-COMMONLY CALLED SINUSITIS
-MOST CASES START WITH COLD OR FLU
-SINUS INFLAMMATION OCCURS IN MOST COLDS
-IN SMALL % OF PEOPLE, SINUS INFLAMMATION CAUSES SINUSITIS
-NASAL POLYPS CAN CAUSE SINUSITIS
Term
RESPIRATORY TRACT INFECTIONS:
ACUTE VIRAL RHINOSINUSITIS DURATION
Definition
LASTS 5-7 DAYS
Term
RESPIRATORY TRACT INFECTIONS:
ACUTE BACTERIAL RHINOSINUSITIS DURATION
Definition
LASTS UP TO 4 WEEKS
Term
RESPIRATORY TRACT INFECTIONS:
SUBACUTE SINUSITIS DURATION
Definition
-12-14 WEEKS (PROBABLY BACTERIAL)
Term
RESPIRATORY TRACT INFECTIONS:
CHRONIC SINUSITIS DURATION
Definition
-LASTS MORE THAN 12 WEEKS (PROBABLY BACTERIAL)
Term
SUNUSITIS:
SYMPTOMS
Definition
-PAIN
-TENDERNESS
-SWELLING OVER SINUS INVOLVED
-CONGESTION
-NASAL BLOCKAGE
-DECREASED SMELL
-PRODUCTIVE COUGH
-PURULENT NASAL DISCHARGE
Term
SUNUSITIS:
TREATMENT OF VIRAL
Definition
DECONGESTANTS
Term
SUNUSITIS:
TREATMENT OF BACTERIAL
Definition
ANTIBIOTICS
Term
INFLUENZA:
FACTS
Definition
-APPROX. 36000 PEOPLE DIE ANNUALLY FROM INFLUENZA-RELATED ILLNESS
-VIRUS TRANSMITTED BY AEROSOL (3 OR MORE PARTICLES) OR DIRECT CONTACT
-PEOPLE ARE INFECTIOUS 1 DAY BEFORE ONSET OF SYMPTOMS
-
Term
INFLUENZA:
CAN CAUSE
Definition
-UPPER RESPIRATORY INFECTION (RHINOTRACHEITIS)
-VIRAL PNEUMONIA
-Respiratory viral infection followed by a bacterial infection
Term
INFLUENZA:
TREATMENT
Definition
-ANTIBIOTICS FOR SECONDARY BACTERIAL INFECTION
-ANTIVIRAL TREATMENT IN SOME CASES MUST BEGIN WITHIN 30 HOURS OF SYMPTOMS
Term
INFLUENZA:
IMMUNIZATION
Definition
-INJECTED (MOST COMMON)
-INTRANASAL
Term
PNEUMONIA:
FACTS
Definition
-INFLAMMATION OF BRONCHIOLES, LUNG AND SOMETIMES PLEURA
-6TH LEADING CAUSE OF DEATH IN US
-MAJOR CAUSE OF DEATH IN ELDERLY AND IMMUNOCOMPROMISED INDIVIDUALS
-USUALLY WHEN IMMUNE SYSTEM IS WEAKENED BY UPPER RESP. TRACT INFECTION OR INFLUENZA
Term
INFLUENZA:
CAUSED BY
Definition
-BACTERIA NORMALLY FOUND IN NASOPHARYNX OR OROPHARYNX ASPIRATED INTO LUNG
-PATHOGENS SPREAD BY INHALED RESPIRATORY DROPLETS
Term
PNEUMONIA:
CLASSIFICATION
Definition
CLASSIFIED BY
type of agent (typical or atypical) causing pneumonia
distribution of pneumonia (lobar pneumonia or bronchopneumonia)
setting (community or hospital) in which it occurs
Term
TYPICAL PNEUMONIA:
CAUSED BY
Definition
-BACTERIA IN ALVEOIL
-STREPTOCOCCUS PNEUMONIAE MOST COMMON CAUSE
Term
TYPICAL PNEUMONIA:
MANIFESTATIONS
Definition
-INFLAMED ALVEOLI FILL WITH EXUDATE
-PRODUCTS OF INFLAMMATION ACCUMULATE IN ALVEOLI CAUSEING A SOLID MASS IN LUNG THAT CAN BE SEEN IN X-RAY
-FILLING OF ALVEOLI DECREASES OXYGEN CAUSEING HYPOXEMIA AND DYSPNEA, CRACKLES IN BREATH SOUNDS
Term
TYPICAL PNEUMONIA:
SYMPTOMS
Definition
-COMES ON SUDDENLY
-HIGH FEVER, SHAKING CHILLS
-PRODUCTIVE COUGH, COLORED SPUTUM
-CHEST PAIN
-SHORTNESS OF BREATH
-CRACKLING BREATH SOUNDS
Term
COMMUNITY ACQUIRED PNEUMONIA:
Definition
-CAUSED BY ORGANISMS FOUND IN THE COMMUNITY RATHER THAN A HOSPITAL OR NURSING HOME
-CAN BE BACTERAIL OR VIRAL
Term
COMMUNITY ACQUIRED PNEUMONIA:
MOST COMMON CAUSES
Definition
STREPTOCOCCUS PNEUMONIAE
Term
COMMUNITY ACQUIRED PNEUMONIA:
LEGIONAIRES DISEASE
Definition
-COMMUNITY-ACQUIRED PNEUMONIA
-CAUSED BY BACTERIA lEGIONELLA PNEUMOPHILIA FOUND IN WARM STANDING WATER
*FACTORS THAT INCREASE RISK*
-SMOKING
-CHRONIC DISEASE
-IMPAIRED CELL MEDIATED IMMUNITY
Term
HOSPITAL-ACQUIRED PNEUMONIA
Definition
-NOSOCOMIAL PNEUMONIA
-NOT PRESENT OR INCUBATING ON ADMISSION TO HOSPITAL OR NURSING HOME
-SECOND MOST COMMON NOSOCOMIAL INFECTION
-MOST ARE BACTERIAL
-
Term
TUBERCULOSIS
Definition
WORLD'S FOREMOST CAUSE OF DEATH FROM A SINGLE INFECTIOUS AGENT, CAUSES 26% OF AVOIDABLE DEATHS IN DEVELOPING COUNTRIES
Term
TUBERCULOSIS:
DRUG RESISTANT FORMS
Definition
MYCOBACTERIUM TUBERCULOSIS HOMINIS
-HAS A PROTECTIVE WAXY CAPSULE THAT RESISTS DESTRUCTION
-CAN STAY ALIVE IN SUSPENDED ANIMATION FOR YEARS
Term
TUBERCULOSIS:
SPREAD OF
Definition
-AIRBORNE INFECTION SPREAD BY DROPLETS IN RESPIRATORY SECRETION OF PEOPLE W/ ACTIVE TUBERCULOSIS
-COUGHING, SNEEZING, TALKING
-DROPLETS EVAPORATE AND LEAVE ORGANISMS SUSPENDED IN AIR
Term
TUBERCULOSIS:
INFECTION
Definition
-Bacilli multiply in alveoli of lungs. Alveolar macrophages attack bacilli but cannot destroy it.
-Macrophages stimulate a cell-mediated immune response. Cell mediated immune response causes damage to lung tissue
-Cell-mediated immune response results in positive TB skin test
-Bacilli are isolated in lung tissue within a granuloma (tubercle)
-Tubercle is area of initial infection of airborne bacteria and contains the bacilli, macrophages and other immune cells
-Infected tissues in tubercle die reuslting in caseous necrosis (dead tissue resembles cheese-like material)
-Scar tissue grows around tubercle walling it off
Term
TUBERCULOSIS:
PRIMARY INFECTIONS
Definition
-Primary infection: Develops in someone who has not been previously exposed
-Immune cells wall off and isolate bacilli in granuloma. Infection is called a latent infection
-Usually asymptomatic
-Individuals with a latent infection cannot transmit TB to others
Term
TUBERCULOSIS:
PROGRESSIVE PRIMARY INFECTIONS
Definition
-In 5% of individuals with primary infection, immune response does not contain the bacteria
-Bacteria spreads to multiple sites in lung and more lung tissue is destroyed
-Symptoms are nonspecific: fever, weight loss, fatique, and night sweats.
-Bacteria can spread to sputum and person becomes infectious
Term
TUBERCULOSIS:
SECONDARY
Definition
-Reinfection from inhaled droplet nuclei
-Reactivation of a previously healed primary lesion
-Immediate cell-mediated response walls off infection in airways
-Bacteria damage tissues in the airways, creating cavities (cavitary tuberculosis)
-Signs of chronic pneumonia: gradual destruction of lung tissue
-Eventually fatal if untreated
-Consumption is wasting seen in severe secondary TB
Term
LUNG CANCER:
DEATH FROM
Definition
-LUNG CANCER IS THE LEADING CAUSE OF CANCER DEATH
Term
LUNG CANCER:
EFFECT OF SMOKING
Definition
SMOKING CAUSES GENETIC CHANGES THAT CONVERT NORMAL BRONCHIAL CELLS TO CANCER CELLS
Term
LUNG CANCER:
BRONCHIOGENIC CARCINOMA
Definition
-95 % OF LUNG CANCERS
-ARISE FROM BRONCHIAL EPITHELIUM
-CATEGORIZED AS:
-SMALL CELL LUNG CANCER
-NON-SMALL-CELL LUNG CANCER
*LARGE CELL CARCINOMA
*SQUAMOUS CELL
*ADENOCARCINOMA
Term
LUNG CANCER:
MANIFESTATIONS
Definition
-CHANGES IN ORGAN FUNCTION
-LOCAL EFFECTS OF TUMORS
-ECTOPIC HORMONES SECRETED BY TUMOR CELLS
-NONSPECIFIC SIGNS OF TISSUE BREAKDOWN
Term
CHILDHOOD REPIRATORY INFECTIONS:
CROUP
Definition
-AFFECTS CHILDREN 3 MO TO 5 YRS.
-USUALLY FOLLOWS A COLD
Term
CHILDHOOD REPIRATORY INFECTIONS:
CROUP SYMPTOMS
Definition
-BARKING COUGH
-STRIDOR (HIGH PITCHED SOUND DUE TO AIRWAY OBSTRUCTION)
Term
CHILDHOOD REPIRATORY INFECTIONS:
CROUP TREATMENT
Definition
-USUALLY CAN BE MANAGED AT HOME WITH HIGH HUMIDIFICATION
Term
CHILDHOOD REPIRATORY INFECTIONS:
EPIGLOTTITIS
Definition
AFFECTS CHILDREN 2-7 YRS.
Term
CHILDHOOD REPIRATORY INFECTIONS:
EPIGLOTTITIS CAUSED BY
Definition
HAEMOPHILUS INFLUENZA
-LESS COMMON BECAUSE OF IMMUNIZATIONS
Term
CHILDHOOD REPIRATORY INFECTIONS:
EPIGLOTTITIS ONSET
Definition
-SUDDEN ONSET LIFE THREATENING
Term
CHILDHOOD REPIRATORY INFECTIONS:
EPIGLOTTITIS TREATMENT
Definition
-MAY REQUIRE INTUBATION OT TRACHEOTOMY
-ANTIBIOTICS
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