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Pathophysiology
Gastrointestinal Pathophysiology
80
Biology
Undergraduate 2
03/23/2012

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Term
GI TRACT ORGAN WALLS:
LAYERS
Definition
-MUCOSA
-SUBMUCOSA
-MUSCULARIS
-SEROSA
Term
GI TRACT ORGAN WALLS:
MUCOSA
Definition
-INNER LAYER
-EPITHELIUM OF MUCOSA LINES LUMEN
Term
GI TRACT ORGAN WALLS:
SUBMUCOSA
Definition
-CONNECTIVE TISSUE THAT BIND MUCOSA TO MUSCULARIS
Term
GI TRACT ORGAN WALLS:
MUSCULARIS
Definition
-CONTRACTION OF MUSCLE IN THIS LAYER MOVES FOOD THROUGH DIGESTIVE TRACT
Term
GI TRACT ORGAN WALLS:
SEROSA
Definition
OUTER LAYER
Term
GI TRACT FUNCTION:
MOUTH
Definition
-SALIVERY SECRETIONS MOISTEN FOOD, BEGIN STARCH DIGESTION
-SALIVARY AMYLASE BREAKS DOWN STARCH INTO GLUCOSE
-MASTICATION MECHANICALLY BREAKS DOWN FOOD
-TONGUE MOVES FOOD
-CHEWED FOOD MOVED FROM MOUTH TO PHARYNX
Term
GI TRACT FUNCTION:
PHARYNX AND ESOPHAGUS
Definition
-NO DIGESTION, ONLY PASSAGEWAYS FOR FOOD
Term
GI TRACT FUNCTION:
ESOPHAGUS
Definition
-PERISTALSIS (CONTRACTION AND RELAXATION MOVES FOOD BOLUS FROM PHARYNX TO STOMACH)
-UPPER ESOPHAGEAL SPHINCTER REGULATES PASSAGE OF FOOD FROM PHARYNX TO ESOPHAGUS
-LOWER ESOPHAGEAL SPHINCTER REGULATES PASSAGE OF FOOD FROM ESOPHAGUS TO STOMACH
Term
GI TRACT FUNCTION:
STOMACH MIXING
Definition
MIXING WAVES ARE MUSCLE CONTRACTIONS THAT MIX FOOD BOLUS WITH GASTRIC JUICES TO FORM CHYME
Term
GI TRACT FUNCTION:
STOMACH GASTRIC JUICES
Definition
-ACIDIC FLUID THAT CONTAINS HCI AND PEPSIN
-HCI DENATURES PROTEIN
-PEPSIN BREAKS DOWN PROTEIN
Term
GI TRACT FUNCTION:
STOMACH ABSORPTION
Definition
ABSORPTION IS LIMITED, ONLY WATER, ALCOHOL AND ASPIRIN ABSORBED
Term
GI TRACT FUNCTION:
STOMACH PERISTALSIS
Definition
MUSCLE CONTRACTION THAT MOVES CHYME FROM STOMACH TO SM. INTESTINE
Term
GI TRACT FUNCTION:
STOMACH PYLORIC SPHINCTER
Definition
-CONTROLS MOVEMENT OF CHYME FROM STOMACH TO DUODENUM
-PREVENTS BACKFLOW OF CHYME TO STOMACH
Term
GI TRACT FUNCTION:
PANCREAS INVOLVEMENT
Definition
-SECRETED DIGESTIVE ENZYMES INTO SM. INTESTINE
-AMYLASE BREAKS DOWN STARCH TO SUGAR
-LIPASE BREAK DOWN FATS TO TRIGLYCERIDES AND GLYCEROL
-PROTEASES BREAK DOWN PEPTIDES TO AMINO ACIDS
Term
GI TRACT FUNCTION:
LIVER INVOLVEMENT
Definition
-SECRETES BILE INTO SM. INTESTINE
-BILE EMULSIFIES FAT SO THERE IS GREATER SURFACE AREA FOR LIPASES TO BREAK DOWN FATS
Term
GI TRACT FUNCTION:
SMALL INTESTINE DIVISIONS
Definition
-DUODENUM (BEGINNING OF SM. INTESTINE)
-JEJUNUM (MIDDLE SECTION)
-ILEUM (JOINS TO LG. INTESTINE)
Term
GI TRACT FUNCTION:
SMALL INTESTINE AND DIGESTION
Definition
-MAJOR SITE OF DIGESTION & ABSORPTION OF NUTRIENS & WATER
-MAJORITY OF ENZYMES MADE IN PANCREAS AND SECRETED INTO SM. INTESTINE
Term
GI TRACT FUNCTION:
SMALL INTESTINE ABSORPTION
Definition
MAJORITY OF ABSORPTION OF SUGARS TRIGLYCERIDES, AMINO ACIDS AND WATER TAKES PLACE IN SM. INTESTINE
Term
GI TRACT FUNCTION:
SMALL INTESTINE SEGMENTATION
Definition
CONTRACTIONS THA TMIX CHYME W/ DIGESTIVE JUICES AND INCREASE ABSORPTION
Term
GI TRACT FUNCTION:
SMALL INTESTINE MIGRATING MOTILITY COMPLEX
Definition
-TYPE OF PERISTALSIS THAT MOVES CHYME TOWARD ILEOCECAL SPHINCTER
Term
GI TRACT FUNCTION:
SMALL INTESTINE ILEOCECAL SPHINCTER
Definition
-CONTROLS PASSAGE OF FOOD FROM ILEUM TO LG. INTESTINE
Term
GI TRACT FUNCTION:
LARGE INTESTINE DIGESTION & ABSORPTION
Definition
-BACTERIA SECRETE ENZYMES THAT BREAK DOWN UNDIGESTED MATERIALS INTO PRODUCTS THAT ARE EITHER ABSORBED OR EXPELLED IN FECES
-BACTERIA SYNTHESIZE VIT. K AND CERTAIN B VITAMINS THAT ARE ABSORBED BY COLON
-REMAINING WATER ABSORBED FROM FECES
Term
GI TRACT FUNCTION:
LARGE INTESTINE PERISTALSIS
Definition
MUSCLE CONTRACTIONS THAT MOVE FECAL MATTER THROUGH COLON
Term
GI TRACT FUNCTION:
LARGE INTESTINE; DEFECATION
Definition
CONTRACTION ON SIGMOID COLON AND RECTUM ELIMINATE FECES
Term
ESOPHAGUS:
DISORDERS
Definition
-DYSPHAGIA
-ACHALASIA
-ESOPHAGEAL DIVERTICULUM
-GI REFLUX DISEASE
-HIATAL HERNIA
-CANCER OF THE ESOPHAGUS
Term
ESOPHAGUS:
DYSPHAGIA
Definition
-DIFFICULTY SWALLOWING
-CAUSED BY ALTERED NERVE FUNCTION, STROKE, NARROWING OF THE ESOPHAGUS
Term
ESOPHAGUS:
ACHALASIA
Definition
LOWER ESOPHAGEAL SPHINCTER FAILS TO RELAX, AND FOOD HAS DIFFICULTY PASSING INTO STOMACH
Term
ESOPHAGUS:
DIVERTICULUM
Definition
-POCKETS OR SACS IN ESOPHAGEAL WALL THAT TRAP FOOD
-CAUSED BY WEAKNESS OF THE MUSCULARIS LAYER OF ESOPHAGUS
Term
ESOPHAGUS:
HIATAL HERNIA
Definition
-Lower esophageal sphincter passes through gap or hiatus in diaphragm
-Enlargement of gap can cause herniation of stomach into thorax
-Reflux of stomach contents into esophagus can cause burning (heartburn)
-Can be caused by aging trauma, surgery, obesity, pregnancy. Can also be hereditary.
Term
GASTROESOPHAGEAL REFLUS DISEASE (GERD):
MOVEMENT OF STOMACH CONTENTS INTO ESOPHAGUS
Definition
Causes heartburn
Occurs if lower esophageal sphincter is weak and cannot completely close after food enters stomach
Pressure difference between stomach and esophagus forces food into esophagus
Term
GERD:
ACID IRRITATION
Definition
-Stomach contents are acidic and irritate esophageal lining (mucosa)
-Number of mucus producing cells in mucosa of esophagus less than in mucosa of stomach
-Not enough mucus to protect musosa of esophagus from acidic stomach contents
-Severe GERD causes damage to epithelial lining and can result in erosion of muscularis
Term
GERD:
CAUSES
Definition
PREGNANCY
OBESITY
OVEREATING
Term
GERD:
SYMPTOMS
Definition
-HEARTBURN
-REGURGITATION
-DYSPHAGIA
Term
STOMACH:
DISORDERS
Definition
-GASTRITIS
-GASTRIC ATROPHY
-PERNICIOUS ANEMIA
-ULCER DISEASE
-CANCER OF STOMACH
Term
STOMACH DISORDER:
GASTRITIS (MUCOSAL BARRIER)
Definition
-EPITHELIAL CELLS TIGHT TOGETHER TO PREVENT PENETRATION OF GASTRIC JUICES INTO SUBMUCOSA
-MUCUS ADHERES TO LINING TO PROTECT FROM GASTRIC JUICES
Term
STOMACH DISORDER:
GASTRITIS (DAMAGE CAUSED BY)
Definition
-H+ CAUSES DAMAGE OF MUCOSA
Term
STOMACH DISORDER:
GASTRITIS (SYMPTOMS)
Definition
-PAIN
NAUSEA AND VOMITING (DUE TO IRRITATION OF MUCOSA)
Term
STOMACH DISORDER:
GASTRITIS TYPES
Definition
ACUTE-CAUSED BY: ENDOTOXINS, ALCOHOL, NSAIDS
CHRONIC-CAUSED BY: HELIOBACTER PYLORI
Term
STOMACH DISORDER:
GASTRIC ATROPHY
Definition
-CAUSES BY CHRONIC GASTRITIS
-CAN RESULT IN:
*ACHYLORDIA(FALIURE TO PRODUCE HCI)
*HYPOCHLORHYDIA (DECREASED HCI SECRETION)
Term
STOMACH DISORDER:
PERNICIOUS ANEMIA
Definition
-ABSENCE OF INTRINSIC FACTOR
-CAN BE CAUSED BY GASTRIC ATROPHY AND ACHYLORHYDIA
Term
STOMACH DISORDER:
ULCERS
Definition
-PEPTIC ULCERS:STOMACH
-DUODENAL ULCERS: DUODENUM
-CAUSED MOSTLY BY H. PYLORI BACTERIA, SOME CAUSED BY NSAIDS
Term
STOMACH DISORDERS:
STRESS ULCERS
Definition
USUALLY FOLLOW SEVERE ILLNESS SUCH AS BURNS, TRAUMA, SURGERY, SHOCK OR RENAL FAILURE
Term
STOMACH DISORDER:
pEPTIC ULCERS SYMPTOMS
Definition
*GASTRIC ULCERS:
-HEARTBURN AND EPIGASTRIC PAIN IMMEDIATELY AFTER EATING
*DUODENAL ULCERS
-RIGHT EPIGASTRIC PAIN WHEN STOMACH IS EMPTY
Term
STOMACH DISORDER:
CANCER
Definition
THE FOLLOWING FACTORS INCREASE RISK OF STOMACH CANCER:
-H. PYLORI INFECTION
-CHRONIC GASTRITIS
-CARCINOGENIC FOODS IN DIET
Term
SMALL INTESTINE DISORDERS:
Definition
-INCOMPLETE DIGESTION OF FOOD
-MALABSORPTION OF NUTRIENTS (SPRUE)
Term
SMALL INTESTINE DISORDERS:
INCOMPLETE DIGESTION OF FOOD
Definition
-Lack of pancreatic digestive enzymes that break down carbohydrates, proteins, and fats into absorbable units
-Over ½ fat not absorbed and 1/3 – ½ of proteins and carbohydrates not absorbed
-Results in malnutrition and steatorrhea (excessive fat in feces)
Term
SMALL INTESTINE DISORDERS:
MALABSORPTION OF FOOD
Definition
-NUTRIENTS NOT ABSORBED EVEN THOUGH FOOD IS DIGESTED
Term
SMALL INTESTINE DISORDERS:
MALABSORPTION OF FOOD (SPRUE)
Definition
-DISEASES THAT CAUSE DECREASED ABSORPTION BY MUCOSA OF SM. INTESTINE
-EARLY STAGES: MALABSORPTION OF FATS CAUSING STEATORRHEA
-SEVERE: MALABSORPTION OF NUTRIENTS CAUSING WASTING, OSTEOMALACIA, LACK O CLOTTING AND PERNICIOUS ANEMIA
Term
SMALL INTESTINE DISORDERS:
GLUTEN SENSITIVE HYPERTROPHY (CELIAC)
Definition
-GLUTEN DESTROYS MICROVILLI IN SM. INTESTINE
-DECREASES SURFACE AREA FOR ABSORPTION, CAUSING MALNUTRITION
Term
SMALL INTESTINE DISORDERS:
CELIAC SYMPTOMS IN CHILDREN
Definition
-ABDOMINAL BLOATING/PAIN
-CHRONIC DIARRHEA
-VOMITING
-ABNORMAL STOOL
-WEIGHT LOSS
-FAILURE TO THRIVE, SHORT STATURE
Term
SMALL INTESTINE DISORDERS:
CELIAC SYMPTOMS IN ADULTS
Definition
-unexplained iron-deficiency anemia
-fatigue
-bone or joint pain
-arthritis
-bone loss or osteoporosis
-depression or anxiety
-tingling numbness in the hands and feet
-seizures
-missed menstrual periods
-infertility or recurrent miscarriage
-canker sores inside the mouth
-an itchy skin rash called dermatitis herpetiformis
Term
LARGE INTESTINE DISORDERS:
Definition
-DIARRHEA
-INFLAMMATORY BOWEL DISEASE
-INFECTIOUS ENTEROCOLITIS
-DIVERTICULAR DISEASE
Term
LARGE INTESTINE DISORDERS:
DIARRHEA
Definition
-RAPID MOVEMENT OF FECAL MATTER THROUGH LG. INTESTINE
-CAN RESULT IN DEHYDRATION
Term
LARGE INTESTINE DISORDERS:
DIARRHEA CAUSED BY
Definition
-INFECTIOUS ENTEROCOLITIS: BACTERIA OR VIRUS
-PSHCHOGENIC DIARRHEA: NERVOUSNESS
-ULCERATIVE COLITIS: INFLAMMATION AND ULCERATION OF LG. INTESTINE WALLS
-
Term
LARGE INTESTINE DISORDERS:
CROHN'S DISEASE
Definition
INFLAMMATORY DISEASE OF THE INTESTINES
Term
LARGE INTESTINE DISORDERS:
CROHN'S DISEASE INFLAMMATION
Definition
-CAN OCCUR ANYWHERE IN GI TRACT
-MOST COMMONLY IN ILEUM AND COLON
-INVOLVE ALL LAYERS OF THE INTESTINAL WALL
Term
LARGE INTESTINE DISORDERS:
CROHN'S DISEASE TYPES OF LESIONS
Definition
-ULCERS
-GRANULOMAS
-FISSURES
Term
LARGE INTESTINE DISORDERS:
CROHN'S DISEASE LESIONS CAN CAUSE
Definition
-EDEMA AND FIBROSIS OF INTESTINAL WALL
-FISTULAS AND ABSESSES
-SKIP LESIONS
Term
LARGE INTESTINE DISORDERS:
CROHN'S DISEASE-WHAT CAUSES IT
Definition
-CAUSE UNKNOWN
-MAY BE DUE TO ABNORMAL RESPONSE TO NORMAL BACTERIA
-RUNS IN FAMILIES
SMOKING INCREASES RISK
Term
LARGE INTESTINE DISORDERS:
CROHN'S DISEASE SYMPTOMS
Definition
-NAUSEA
-VOMITING
-FLATULENCE
-MALAISE
-WEIGHT LOSS
-MULTIPLE STOOLS DAILY
-PAIN IN LOWER RIGHT QUADRANT
-MUCUS IN STOOLS
Term
LARGE INTESTINE DISORDERS:
ULCERATIVE COLITIS
Definition
-INFLAMMATORY DISEASE AFFECTING MUCOSA OF COLON
-INFLAMMATION ALONG WHOLE COURSE OF COLON
-CAUSES ULCERS THAT MAY BECOME FIBROTIC IN LATER STAGE OF DISEASE
-NO SKIP LESIONS OR FISTULAS
Term
LARGE INTESTINE DISORDERS:
ULCERATIVE COLITIS COMPLICATIONS
Definition
-INTESTINAL OBSTRUCTION
-DEHYDRATION
-FLUID AND ELECTROLYTE IMBALANCES
-MALABSORPTION
-IRON DEFICIENCY
-SCARRING OF BILE DUCT
-LIVER DISEASE
-TOXIC MEGACOLON(SWELLNG TO MANY X'S NORMAL SIZE)
-RISK OF COLON CANCER
Term
LARGE INTESTINE DISORDERS:
ULCERATIVE COLITIS CAUSED BY
Definition
-UNKNOWN CAUSE
-MAY BE DUE TO ABNORMAL IMMUNE RESPONSE TO NORMAL BACTERIA
-STRESS DOES NOT CAUSE, BUT MAY WORSEN
Term
LARGE INTESTINE DISORDERS:
ULCERATIVE COLITIS
Definition
-CHRONIC BLOODY DIARRHEA MIXED WITH MUCUS
-OTHER SYMPTOMS SIMILAR TO CROHN'S DISEASE
Term
LARGE INTESTINE DISORDERS:
INFECTIOUS ENTEROCOLITIS
Definition
-Infections can be caused by viruses, bacteria, protozoa, endotoxins released by bacteria
-Most infections spread by oral-fecal route, often through contaminated food or water
-Signs: diarrhea and vomiting
Decreased intestinal function
Term
LARGE INTESTINE DISORDERS:
VIRAL INFECTIOUS ENTEROCOLITIS
Definition
-Destroys superificial epithelial cells that line small intestine
-Superifical cells replaced with immature cells that incompletely absorb nutrients and water
-Deeper secretory cells not destroyed so have fluid with electrolytes still secreted
-Fluid and electrolytes lost with diarrhea
Term
LARGE INTESTINE DISORDERS:
VIRAL INFECTIOUS ENTEROCOLITIS (RETROVIRUS)
Definition
Rotovirus: causes enterocolitis
-Most severe in children 3-24 months of age
-Breast-feeding helps protect against disease
-Frequent water stools last for 5-7 days
-Fever and vomiting disappear on second day
Term
LARGE INTESTINE DISORDERS:
BACTERIAL ENTEROCOLITIS
Definition
-ClostrIdium difficile colitis
-Toxins released by bacteria cause inflammation and stimulates peristalsis
-Moderate to severe diarrhea with abdominal cramping
Term
LARGE INTESTINE DISORDERS:
DIVERTICULOSIS
Definition
-Formation of diverticula (small pockets or sacs) in wall of colon. -(“o” in osis indicates formation of diverticula)
-Occur when musosal layer of colon herniates through muscularis layer
-Usually asymptomatic
Term
LARGE INTESTINE DISORDERS:
DIVERTICULITIS
Definition
-Inflammation and perforation of diverticula.
- (“i” in -itis indicates inflammation of diverticula)
-Complications include perforation with peritonitis, hemorrhage, bowel obstruction and fistulas involving bladder
Term
LARGE INTESTINE DISORDERS:
CONSTIPATION
Definition
SLOW MOVEMENT OF FECES THROUGH LG. INTESTINE RESULTS IN OVERABSORPTION OF WATER AND DRY HARD FECES
Term
LARGE INTESTINE DISORDERS:
CONSTIPATION CAUSED BY
Definition
-IRREGULAR BOWEL HABITS
-LACK OF FIBER OR FLUID IN DIET
Term
LARGE INTESTINE DISORDERS:
OBSTRUCTION
Definition
BLOCKAGE OF INTESTINAL LUMEN PREVENTING PASSAGE OF FECES
Term
LARGE INTESTINE DISORDERS:
OBSTRUCTION-TYPES
Definition
-MECHANICAL OBSTRUCTION (ANY CONDITION THAT BLOCKS LUMEN)
-FUNCTIONAL OR PARALYTIC OBSTRUCTION (IMPAIRMENT OF NERVES OR MUSCLES THAT INHIBITS PERISTALSIS)
Term
LARGE INTESTINE DISORDERS:
THE VICIOUS CYCLE
Definition
ONE TYPE OF BOWEL PROBLEM CAN CAUSE ANOTHER
Term
LARGE INTESTINE DISORDERS:
HEMORRHAGE -FRANK HEMATAMESIS
Definition
HEMORRHAGE ABOVE THE STOMACH
Term
LARGE INTESTINE DISORDERS:
HEMORRHAGE -COFFE-GROUNDS VOMITUS
Definition
HEMORRHAGE INTO THE STOMACH W/ PARTIAL DIGESTION OF BLOOD
Term
LARGE INTESTINE DISORDERS:
HEMORRHAGE -OCCULT BLOOD
Definition
HEMORRHAGE IN THE INTESTINE W/ BLOOD MIXING INTO STOOLS
Term
LARGE INTESTINE DISORDERS:
HEMORRHAGE -MELENA
Definition
HEMORRHAGE INTO THE ITESTINES W/ LG. VOLUMES OF BLOOD
Term
LARGE INTESTINE DISORDERS:
HEMORRHAGE -RED BLOOD COATING STOOLS
Definition
HEMORRHAGE IN THE RECTUM
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