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Pathophysiology
Focus 1 & 2 First Exam
68
Physiology
Undergraduate 3
09/13/2010

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Term
Fat necrosis (3 parts)
Definition
1. Caused by enzymes-lipases (that breakdown fat) 2. Examples: Breast, pancreas, abdominal structures 3. Opaque, chalk white appearances
Term
Gangrenous Necrosis
Definition
Hypoxia with bacterial invasion
Term
Dry gangrene
Definition
Coagulative necrosis
Term
Wet gangrene
Definition
Liquefactive necrosis
Term
Gas gangrene
Definition
Clostridium bacteria
Term
Apoptosis
Definition
Natural process, caused by too much or too little apoptosis (see notes)
Term
Somatic Death
Definition
Death of entire person
Term
Algor mortis
Definition
Reduction of body temperature to environmental temp.
Term
Livor mortis
Definition
Gravity causes blood to pool in dependent areas
Term
Rigor mortis
Definition
Muscle stiffening (See notes for time period)
Term
Body Fluids
Definition
2/3 - 1/3
Term
Hydrostatic pressue pushes fluid (IN/OUT)
Definition
Out
Term
Osmotic pressure pulls fluid (IN/OUT)
Definition
In
Term
Starling's Law of the Capillaries
Definition
Hydrostatic pressure pushes fluid out, Osmotic pressure pulls fluid in
Term
Fluid Movement - Arterial side
Definition
Hydrostatic pressure is higher than osmotic pressure, fluid moves out of the blood
Term
Fluid Movement - Venous side
Definition
Osmotic pressure is higher than hydrostatic pressure. Fluid moves into the blood
Term
Edema
Definition
Accumulation of fluid in the interstitial spaces (between cells)
Term
Causes of Edema (4 parts)
Definition
Increased hydrostatic pressure, Decreased plasma osmotic pressure, Increased capillary permeability, Obstruction or removal of the lymphatic system
Term
ADH causes ___________________
Definition
water reabsorption from kidney
Term
Renin-angiotensin-aldosterone system
Definition
Causes sodium and water reabsorption, potassium excretion (See notes for diagram)
Term
Atrial Natriuretic Peptide
Definition
Causes sodium and water excretion (See notes for diagram)
Term
Normal Serum Sodium
Definition
135-147 mEq/L
Term
Sodium Imbalance
Definition
See Notes for diagram
Term
Normal Serum Potassium
Definition
3.5-4.5 mEq/L
Term
Normal blood pH
Definition
7.35-7.45
Term
Acidosis
Definition
Less than 7.35
Term
Alkalosis
Definition
Greater than 7.45
Term
Acid-Base Balance
Definition
Hydrogen ion concentration
Term
Protein buffers
Definition
Hemoglobin can bind with H+ and CO2
Term
Acid-Base Regulatory Mechanisms (LUNGS)
Definition
Lungs increase or decrease CO2
Term
Acid-Base Regulatory Mechanisms (KIDNEYS)
Definition
Kidneys retain or excrete H+ and bicarbonate
Term
Metabolic Acidosis
Definition
Decreased HCO3 (See notes)
Term
Metabolic Alkalosis
Definition
Increased HCO3 (See notes)
Term
Respiratory Acidosis
Definition
Increased CO2 (See notes)
Term
Respiratory Alkalosis
Definition
Decreased CO2
Term
Normal Values - PaCO2
Definition
35-45
Term
Normal Values - HCO3
Definition
22-26
Term
Partial compensation
Definition
All three are abnormal
Term
Complete compensation
Definition
pH is normal
Term
No Compensation
Definition
PaCO2 or HCO3 is normal
Term
CO2
Definition
Alkaline
Term
HCO3
Definition
Acid
Term
Single Gene Disorders (3 types)
Definition
Autosomal dominant, Autosomal recessive, Sex-linked
Term
Abnormal allele is ______________ in Autosomal Dominant (Dominant/Recessive)
Definition
Dominant
Term
Normal allele is ______________ in Autosomal Dominant (Dominant/Recessive)
Definition
Recessive
Term
Phenotype
Definition
Outward physical manifestation of an organism (what we see)
Term
Genotype
Definition
Internally coded, inheritable information carried by all living organisms (what we don't see)
Term
Punnett Square
Definition
Shows genetic information
Term
Huntington's Disease
Definition
Autosomal Dominant
Term
Marfan's Syndrome
Definition
Autosomal Dominant
Term
Neurofibromatosis
Definition
Autosomal Dominant
Term
Autosomal Recessive
Definition
Trait will not be expressed unless both alleles are abnormal
Term
Autosomal Recessive has an ______ age of onset and ______ sees new gene mutation
Definition
early/rarely
Term
Sickle Cell Anemia
Definition
Autosomal Recessive
Term
Cystic Fibrosis
Definition
Autosomal Recessive
Term
Phenylketonuria
Definition
Autosomal Recessive
Term
Sex-Linked Disorders
Definition
Almost always associated with the X chromosome
Term
Sex Linked Disorders recessive in ___________ (m/f)
Definition
Females
Term
Sex-linked Disorders dominant in ______ (m/f)
Definition
Males
Term
Duchenne Muscular Dystrophy
Definition
X-linked Disorder
Term
Hemophilia
Definition
X-linked Disorder
Term
Chromosome Abnormalities (2 types)
Definition
Number and Structure
Term
Monosomy
Definition
Only one chromosome (should have two)
Term
Trisomy
Definition
Have three chromosomes (should have two)
Term
Structure Abnormalities (4 types)
Definition
Deletions, Duplications, Inversions, Translocations
Term
Down Syndrome Trisomy 21 symptoms
Definition
flat nasal bridge, eyes narrow, epicample fold, single crease in hand
Term
Turner Syndrome Monosomy X symptoms
Definition
wide carriage arm, spoon shaped fingernails
Term
Klinefelter Syndrome XXY
Definition
feminine characteristics, usually sterile
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