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Pathophysiology
Pain and Pain Management
16
Physiology
Graduate
12/22/2008

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Cards

Term
Nociceptors
Definition
Fine nerve fibers that receive pain signals
Term
Nociception
Definition
Activation of the nociceptors (activation of pain)
Term
Chronic malignant Pain
Definition
Symptomatic Pain - Where disease or known condition underlies pain
Term
Chronic Benign Pain
Definition
Nonmalignant pain - pain can be disabling, no disease or degeneration is associated with pain to help identify cause.
Term
Two Principles to help define pain for therapeutic regimen
Definition
1. neurophysiology of pain - significant differences exist in the neurological processing, perception, and impact of acute pain compared with chronic pain.

2. Different approaches to pain management are effective with different types of pain.
Term
Acute Pain Classification
Definition
Underlying cause is transitory

Treatment of pain is symptomatic

Resolution based on underlying cause
Term
Autonomic Response
Definition
To keep body systems in homeostasis. I.E. heart rate, blood pressure, secretion of hormones, glucose levels, gastric secretions, temperature, etc.
Term
Hyperalgesia
Definition
Increased sensitivity to pain. Mediated through dorsal horn of the gray matter.
Term
Glutamate
Definition
the excitatory neurotransmitter, binds to the NMDA class of glutamate receptors and permits entry of CA2 into the second order neuron. Nitric oxide is activated
Term
C-Fibers
Definition
unmyelinated fibers in mucous membrane, serous membrane, skin, deep tissue and myocardium. Responsible for dull pain. Action potentials associated with tissue damage or insult. Stimulation produces brandykinin, serotonin, histamine, and potassium in injured tissue.
Term
A Delta Fibers
Definition
in mucous and serous membranes, skin. produce sharp pain sensation. They fire upon intense stimulation then cease when stimulation is removed.
Term
Second Order Neuron
Definition
The neuron that the A delta and C fibers synapses with neurons in the spinal cord.
Term
Mesencephalic Periaqueductal Gray Matter
Definition
an area of cells surrounding the cerebral aqueduct in the mid brain. potentials are relayed to the hypothalamus. neurological basis for endocrine, autonomic, and emotional components of pain response.
Term
Tectum
Definition
Cells in the region of the dorsal midbrain associated with responses to visual and auditory stimuli. They promote spinal cord motor mechanisms, enhancing spinal reflexes and facilitating behavioral responses.
Term
Neospinothalamic Pain Pathway
Definition
A Delta Fibers terminate in the posterior nuclear group in the thalamus. Stimulates the flexor-withdrawal reflex (touching something hot will make you move your hand away, etc)
Term
Paleospinothalmic pain Pathways
Definition
C fibers...discrimination and localization of pain in this system is imprecise.
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