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Pathophysiology slides; spring term (first year)
Cardiac and O2 transport (week 2)
98
Nursing
Not Applicable
04/07/2010

Additional Nursing Flashcards

 


 

Cards

Term
Systolic CHF
Definition

<65 yr

progressive dyspnea

S3(too much filling)

pulmonary congestion

cardiomegaly

<50% ejection fraction

Term
Diastolic CHF
Definition

>65 years

acute dyspnea

S4 (extra beat at first)

pulmonary congestion

left ventricular hypertrophy

normal or small heart

> 50% ejection fraction

Term
Gallop
Definition

S3 and S4

(S4,S1,S2,S3)

Term
Ejection fraction
Definition
SV/EDV
Term
Left Ventricular failure Backward effects
Definition
dec. ejection fraction-->inc. left vent. preload-->inc. left atrial pressure-->inc. pulmonary pressure-->pulmonary congestion. and inc. right vent. afterload which-->right vent. hypertrophy
Term
Left Ventricular failure forward effects
Definition
dec. cardiac output--> dec. tissue perfusion. RAAS activation-->fluid retention which--> inc. left vent. preload (backward effect).
Term
left sided heart failure leads to?
Definition
right sided heart failure. but not opposite.
Term
left vent. failure backward S/S
Definition

Immediate

Dyspnea on exertion

orthopnea

cough

paroxismal nocturnal dyspnea

cyanosis (late sign)

basilar crackles

acute pulmonary edema

Term
Left Vent. failure forward S/S
Definition

fatigue

oliguria

inc. Heart rate

faint pulses

Brain: restlessness, confusion, anxiety

Term
most common cause of CHF
Definition

ischemic caridomyopathy

Caused by CAD and HTN

Term
Systolic CHF basic pathophys
Definition

impaired contractility

ischemia-->no ATP-->negative inotrope-->

Sympathetic nerv. system stimulates beta receptors-->over stimulation.

Term
diastolic CHF basic pathophys
Definition

heart can't fill

common: women, elderly, no prev. MI

impaires calcium removal from muscle

Term
right vent. failure backward effects
Definition
dec. ejection fraction-->inc. right vent. preload-->inc. right atrial pressure-->systemic congestion
Term
Right vent. failure forward effects
Definition
dec. output to left vent.-->dec. left vent. cardiac output-->dec. tissue perfusion. RAAS activation-->fluid retention-->inc right vent. preload(backward effect).
Term
Right vent. failure backward S/S
Definition

hepatomegaly

ascites (portal vein couldn't handle pressure)

splenomegaly

anorexia(pressure on gastric area)

subcutaneous edema

jugular vein distention

kidney congested (dec. GFR kicks in RAAS)

Term
Right vent. failure forward S/S
Definition

dec. perfusion:

fatigue

oliguria

inc. heart rate

faint pulses

restlessness, confusion, anxiety

 

Term
cardiac output equation
Definition
CO=HRxSV
Term
Heart Failure nervous sys. pathway for compensation
Definition

Baroreceptor response-->brain-->SNS activation-->inc. heart rate and contractility-->inc. cardiac output.

Heart is poorly Oxygenated so this increases failure

Term
Heart failure kindney pathway for compensation
Definition

dec. GFR-->RAAS activation-->kidney-->fluid retention-->inc. preload-->inc cardiac output.

heart is poorly oxygenated so this increases failure

Term
heart failure Heart pathway for compensation
Definition

inc. vent. wall tension-->heart-->myocyte growth-->hypertrophy-->inc. cardiac output.

 

increases failure

Term
To dec. preload
Definition

diuretics

keep upright

raise legs (not above heart)

low sodium diet

Term
To dec. afterload
Definition

drugs that dilute

BB's

Term
to improve contractility of heart
Definition

O2(positive inotrope)

inotropes(digoxin)

Term
Improve vent. filling
Definition

BB's (difficult to control)

control symptoms

diuretics

Term
potential complications of left sided heart failure
Definition

pulmonary edema

pleural effusion

renal insufficiency (forward effect)

dysrhythmia

LV thrombus(static blood)

cardiogenic shock (inc. pre/afterload)

 

Term
potential complications of right sided heart failure
Definition

renal insufficiency

hepatomegaly

splenomegaly

dysrhythmia

cardiogenic shock

LV thrombus?

Term
P wave
Definition
atrial depolarization
Term
QRS interval
Definition
Vent. depolarization and atrial repolarization
Term
large Q wave indicates
Definition
infarction or ishemia
Term
T wave
Definition
vent. repolarization
Term
normal sinus rhythm
Definition
60-100 BPM
Term
sinus tachycardia
Definition
> 100 BPM
Term
sinus bradycardia
Definition

<60

dec. cardiac output

Term
stenosis
Definition

doesn't open completely

inc. cardiac workload

Term
regurgitation
Definition

doesn't close completely

increases cardiac workload

Term
Mitral stenosis
Definition

Diastolic murmer

elevated LA pressure

Term
mitral regurgitation
Definition

hypertrophy of LA and LV

regurgitant flow through mitral valve

systolic murmer

Term
aortic stenosis
Definition

LV hypertrophy

dec. CO

Slow heartbeat

 systolic murmer

Term
aortic regurgitation
Definition

LV hypertrophy

head bobs as heart beats

diastolic murmer

 

Term
atrial septal defect
Definition

pulmonary HTN

right vent. hypertrophy

acyanotic

(RV hypertrophy reverses to become cyanotic)

Term
Ventricular septal defect
Definition
acyanotic till RV hypertrophy, then blood reverses into LV to become cyanotic
Term
patent ductus arteriosus
Definition

acyanotic

ductus between ascending aorta and pulmonary artery

Term
Coarctation of the aorta
Definition

narrowing of the aorta

dec. BP to lower body

prone to intercranial hemorrhage

arm and head BP inc.

can lead to CHF

Term
Tetralogy of fallot
Definition

pulmonic valve stenosis

RV hypertrophy

Ventricular septal defect

overriding aorta

Prone to: infective endocarditis. Polycythemia (baby bone marrow making up for lack of O2).

only one that starts cyanotic

Term
acyanotic defect
Definition
oxygenated blood spilling into deoxygenated blood
Term
cyanotic defect
Definition
deoxygenated blood spilling into oxygenated blood
Term
fetus heart dominance
Definition
right side
Term
pulmonary embolism
Definition
undissolved material that occludes pulmonary vasculature
Term
fat embolism
Definition
usually caused by orthopedic surgery(pelvis and femur) or trauma
Term
pulmoary embolism etiologies
Definition
thromboses, labor(amniotic fluid and hair), air, tumor, foreign bodies(man made:sutures, needle caps, bullets), infection, parasites, DVT
Term
Virchows triad
Definition

hypercoaguable state

damage to vessel wall

venous stasis

Term
pulmonary embolism pathogenesis
Definition
thrombus forms-->trauma/excercise/change in blood flow dislodge it-->IVC-->RA-->RV-->lodges in pulmonary vasculature-->SNS response and release of serotonin, histamine, prostaglandins-->vasoconstriction of pulmonary vasculature-->steep pulmonary HTN-->R sided heart failure and dec. CO-->hypotension-->shock(most people die from this)-->SNS response and release of serotonin, histamine, prostaglandins-->pulmonary artery and bronchial artery constriction-->respiratory arrest
Term
pulmonary embolism clinical manifestations
Definition

may not appear until late.

1st: restlessness, anxiety, apprehension

dyspnea(sudden onset is bad sign)

feelings of impending doom

CP, inspiratory pain, hemoptysis

pleuritic CP (hurts to breath in)

Term
pulmonary edema diagnostics
Definition

Va/Q (high?)

ABG's: dec. PaO2, dec. PCO2, inc. PH

EKG: ST and T wave changes

CXR: effusions and infiltrates

pulmonary angiogram (conclusive test)

Term
pulmonary embolism Tx
Definition

prevention of DVT's

O2, anticoagulants, thrombolytics, filter in IVC, embolectomy

Term
Acute respiratory distress syndrome
Definition
sudden, progressive respiratory failure with severe dyspnea, refractory (doesn't respond to Tx) hypoxemia, and diffuse bilateral infiltrates
Term
ARDS pathogenesis
Definition
direct or indirect pulmonary trauma(non cardiogenic)-->massive inflammatory response that increases alveolar cappillary membrane permeablility-->fluid, fibrin, blood, and protiens shift from vasculature into interstitial space-->inc. space between capillary membrane and alveolar membrane--> dec. gas exchange--fluid shifts into alveoli-->pulmonary edema-->dec. gas exchange-->after 7-10 days, dec. surfactant-->atelectasis-->2-3 weeks, irreversible pulmonary fibrosis-->dec. gas exchange and dec. compliance
Term
ARDS late manifestations
Definition

hypoxemia refractory to oxygen leading to:

hypotension

dec. UO

respiratory acidosis

metabolic acidosis

cardiopulmonary arrest

Term
ARDS clinical manifestations
Definition

Hx or recent triggering event, suddent severe dyspnea, tachypnea, tachycardia, hypotension, low PaO2, dec. LOC, crackles, rhonchi, frothy secretions

(lungs can sound clear becuase they are so full of fluid)

Term
ARDS diagnostics
Definition

ABG's: dec. PaO2, inc. PCO2, dec. PH

CXR: white fluffy infiltrates

Va/Q shunt

Term
ARDS Tx
Definition

address the cause

balance F and E

maintain cardiac output-vasopressors

ventilator with PEEP (positive and expiratory pressure)

prone posistion

Term
ARDS potential complications
Definition
dysrhythmias, O2 tox, pneumothorax, renal failure, GIB(GI Bleed), sepsis, DIC(Tx heparin)
Term
Infant respiratory distress syndrome
Definition
respiratory distress from surfactant deficiency and immature thorax development
Term
IRDS etiologies
Definition

prem. infant(<32 wks) has dec. surfactant-->dec. alveolar compliance

prem. infant-->soft compliant chest-->draws in upon inspiration-->dec. intrathoracic pressure

prem. infant-->immature pulmonary capillaries--> hypoxemia

Term
IRDS pathogenesis
Definition

dec. alveolar compliance + dec. intrathoracic pressure-->progressive atelectasis--> reversion to circulation from foramen ovale to ductus arteriosus (R to L shunt)-->hypoxemia-->pulmonary vasoconstriction-->inc. PVR

 

hypoxemia-->anaerobic metabolism of lactic acid-->metabolic acidosis-->pulmonary vasoconstriction

Cellular damage, fluid administration, high levels of FiO2-->inc. cappilary perm.-->pulmonary edema

Term
IRDS clinical manifestations
Definition
often normal color and breathing at birth, within a few hours tachypnea (60-120), accessory muscle use, paradoxical respiration, hypotension, dec. breath sounds, oliguria, bradycardia, frothy sputum, expiratory grunt
Term
IRDS diagnostics
Definition

ABG: dec. PaO2, dec. PH

CXR: diffuse whiteout

Term
IRDS Tx
Definition

Balance F and E

Ventilator with PEEP with as low O2 as possible(high O2 will damage eyes)

exogenous surfactant (bottle?)

minimal handling

controlled temp

Term
IRDS potential complications
Definition
Retinal fibroplasia, pneumothorax
Term
pneumothorax
Definition
presence of air in pleural space that inhibits lung expansion
Term
closed pneumothorax pathogenesis
Definition
respiratory structure rips open(not from outside)-->pleural viscera torn-->air escapes from airway-->seal between visceral and parietal pleura broken-->lung collapses
Term
open pneumothorax pathogenesis (sucking chest wound)
Definition
open hole in chest wall-->parietal pleura is torn-->seal between visceral and parietal pleura broken-->lung collapses-->mediastinal flutter-->severe cardiopulmonary compromise
Term
mediastinal flutter
Definition

heart is pushed to one side on inspiration and swings back on expiration

(seen with open pneumothorax)

Term
tension pneumothorax pathogenesis
Definition

closed or open pneumothorax-->seal between visceral and parietal pleura broken-->lung collapses--air enters pleural space during inspiration and is trapped during expiration-->mediastinal shift (mimics cardiac tamponade)-->compression of contralateral lung, vena cava, aorta, heart-->death

 

Term
clinical manifestations of mediastinal shift
Definition
severe tachycardia, hypotension, tracheal shift, neck vein distension, SQ emphysema (air trapped under skin)
Term
clinical manifestations of pneumothorax
Definition
tachycardia, decreased/hyperresonant (big, empty space) breath sounds on affected side, CP, dyspnea
Term
Diagnostics
Definition

CXR: collapsed lung, shifts in tension pneumothorax

other tests rare

Term
peumothorax Tx
Definition

minor: symptom control only

dressing on open pneumothorax can create tension pneumothorax

insertion of chest tube

pleurodesis for collapsed lung (talcom powder)

 

Term
pleural effusion
Definition
pathological collection of fluid or pus in pleural cavity as a result of a disease process
Term
pleural effusion pathogenesis
Definition

1. inc. hydrostatic pressure of plasma(heart failure?)

2. dec. oncotic pressure of plasma(cirrhosis-low albumin)

3. inc. cappillary permeability(pancreas self digests, dumps gastric juices and destroys capillaries)

4. impaired lymphatic drainage

Term
pleural effusion etiologies
Definition
renal failure/nephrotic syndrom(lose protien in urine), heart failure, cirrhosis, myxedema, pancreatitis, pulmonary embolism, malignancy, infection, hemothorax, chylothorax
Term
pleural effusion clinical manifestations
Definition
pleuritic pain worsening with inspiration, dry cough, dec. chest wall mov't, dec. breath sounds, dec. tactile fremitus (vibration when someone speaks)
Term
pleural effusion diagnostics
Definition

CXR

CT/US

analysis of pleural fluid from thoracentesis

Term
pleural effusion Tx
Definition

thoracentesis

chest tube drainage

treat the underlying cause

Term
pulmonary edema
Definition
abnormal accumulation of fluid in the alveolar sacs and surrounding intersitium
Term
pulmonary edema pathogenesis
Definition
hydrostatic pressure of pulmonary capillaries overwhelms lymphatic drainage of the pulmonary interstitium
Term
pulmonary edema etiologies
Definition

cardiogenic: LV failure, MV stenosis, cardiogenic shock, cardiomyopathy, HTN

Noncardiogenic: fluid overload, aspiration of gastric contents, barotraumas(?), near drowning(fluid breathed in washes away surfactant, lung collapses), hypoalbinemia, O2 tox, ARDS, high altitudes, CNS imbalance

Term
pulmonary edema clinical manifestations
Definition

coughing thin, often pink, frothy sputum

severe dyspnea, tachypnea, thready tachcardia, severe orthopnea, crackles, wheezes, signs of R sided heart failure

Term
pulmonary edema diagnostics
Definition

ABG: dec. SaO2 (plummets), dec PaO2, resp. alkalosis

CXR: whiteout

 

Term
pulmonary edema Tx
Definition

correct hypoxemia: high FiO2, intubation and ventilation

reduce preload: fowlers, diuretics, NTG

reduce afterload: antihypertensives (ACE inhibitors), morphine(slows SNS)

treat underlying cause

Term
pneumonia
Definition
inflammation of alveoli and interstitium
Term
pneumonia etiologies
Definition

aspiration of oropharyngeal secretions

inhalation of infection agent

contamination from systemic circulation

Term
normal pulmonary defense mechanisms
Definition

coughing

sneezing

cilia (smoking paralyzes)

immune defenses

Term
pneumonia pathogenesis
Definition
microbial agent inters lung-->agent multiplies in alveoli septa and spaces--> pulmonary infammation-->inflammatory cells invade alveolar septa-->alveoli fill with liquid exudate-->exudate consolidates and resists clearance-->dec. gas exchange
Term
viral pneumonia
Definition
no exudate
Term
pneumonia clinical manifestations
Definition

fever, crackles, bronchial breath sounds, chills, cough, purulent sputum, older adult may present with mental status changes and dehydration.

viral pneumonia presents fever, coryza(head congestion), hoarseness, wheezes, rales

Term
pneumonia diagnostics
Definition

CXR: white patches

sputum gram stain and culture

Term
pneumonia Tx
Definition

antibiotics

fluid and electrolyte balance

O2, bronchodilators

pulmonary clearance: IS ambulate

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