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pathophysiology of the respiratory system
Tutor notes & Craft, J., Gordon, C., & Tiziani, A. (2011). Understanding pathophysiology. NSW: Elsevier
64
Nursing
Undergraduate 2
09/28/2014

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Term
eupnea
Definition
normal breathing
Term
hyperventilation
Definition
rapid, deep respirations
Term
dyspnea
Definition
laboured or difficult respirations
Term
orthopnea
Definition
relief of dyspnea by moving into an upright or sitting position
Term
apnea
Definition
nil respirations
Term
Cheynne-Stokes respirations (CSR)
Definition
Gradual increase in rapidity of respirations, followed by a decrease rapidity, then total cessation for 5-50 seconds
Term
diseases associated with Cheynne-Stokes respirations
Definition
Kidney failure, heart disease, asthma, increased intracranial pressure
Term
obstructive sleep apnoea
Definition
Excessive snoring followed by multiple apnoea (apnoea lasting for at least 10 seconds)
Term
respiratory arrest
Definition
Inability/failure to recommence respirations after period of apnoea
Term
paroxysmal nocturnal dyspnoea
Definition
a person suddenly awakens due to acute dyspnoea
Term
Kussmaul's respirations
Definition
respirations that are deep and sighing
Term
diseases associated with Kussmaul's
Definition
metabolic acidosis eg. diabetic ketoacidosis and renal failure
Term
define croup and who it affects
Definition
upper respiratory tract is acutely inflamed. Affects children from age of 6 moths- 5 years
Term
list at least 3 viral causes of croup
Definition
parainfluenza, influenza A, respiratory syncytial virus (RSV), adenovirus & measles
Term
2 causes of bacterial croup
Definition
diphtheria or pertussis
Term
region where croup attacks
Definition
subgloittic region: lower portion of the larynx. Region is located from under the vocal cords to the top of the trachea
Term
pathway and clinical manifestations of croup
Definition
increased susceptibility (eg. rhinorrea, fever and a sore throat, also age) -> viral or bacterial invasion -> inflammation of subglottic region -> region narrows (inflammatory response) -> increased work of breathing -> audible stridor, baking cough, strider at rest, tachypnoea and skin retraction during inspiration -> cyanosis (in severe cases)
Term
clinical manifestations of croup
Definition
inflammation of subglottic region causes narrowing. Making work of breathing difficult.
Clinical manifestations: barkin cough, stridor at rest, audible stridor (high pitched hoarse sounds), tachypnoea and skin retraction on inspirations
Term
5 treatments/interventions for croup management
Definition
relieve dysnopea with air that is cool and/or moist,
breath steamy air, use of anti-inflammatory agents (corticosteroids, analgesic and anti-inflammatories), use of aerosols (inhalers) to dilate airways, oxygen therapy in severe cases (hospitalisations)
Term
pneumonia definition
Definition
acute inflammation of the parenchyma of the lungs
Term
parenchyma
Definition
functional parts of the organ
Term
stroma
Definition
structural parts of an organ
Term
list at least 3 causative organisms of pnemonia (community acquired)
Definition
streptococcus pneumonaie, mycoplasma pnemoniae, haemophilus influnzae, respiratory viruses, chlamydia pneumonae
Term
list at least 2 hospital aquired pneumonia causative organisms
Definition
pseudomonas aeruginosa, e-coli, stapylococcus aureus, enterobacter
Term
2 types of pneumonia and describe
Definition
1) lobar pneumonia: affects entire lobe
2) bronchopneumonia: infection scattered along bronchial tree
Term
2 definitions of opportunistic pneumonia
Definition
1) already have a low immune response
2) malnutrition
Term
3 pathophysiology stages of pneumonia after infection
Definition
1) congestion
2) red hepatisation
3) grey hepatisation
Term
pathway of pneumonia pathophysiology
Definition
entry of causative organism through alveoli -> pathogen replicates -> inflammation -> congestion: inflammation process causes alveoli to fill with water and exudate -> red hepatisation: dilation of capillaries allow WBC (neutrophils, monocytes), RBCs and fibrin to migrate alveoli -> grey hepatisation: decrease blood flow to lungs. WBCs and fibrin localised in affected area -> resolution: healing if no complications
Term
4 nursing interventions for pneumonia
Definition
monitor vital signs (TPR, O2 sat, BP)
Position in semi-fowler
encourage slow deep breaths
postural drainage: encourage cough
Term
list at least five complications of pneumonia
Definition
pleurisy (causes chest pain), atelectasis (collapsed airless alveoli), delayed healing process, lung abscesses (especially from staphylococcus Aureus infections), empyema (accumadation of exudate in pleural cavity), necrosis of lungs, sepsis (systemic spread of infection causing pericarditis, arthritis, meningitis, endocarditis), worse scenario: respiratory failure
Term
definition of pulmonary tuberculosis
Definition
chronic, highly contagious lung infection characterised by tubercles in the lung. It can progress to tissues outside of lungs and pleurae
Term
causative organism of TB
Definition
bacterial: mycobacterium tuberculosis bacilli
Term
mode of transmission for TB
Definition
airborne droplets
Term
2 types of TB
Definition
1) active
2) latent
Term
pathophysiology pathway of latent TB infection
Definition
inhaled mycobacterium tuberculosis bacilli inhaled -> multiply in lung tissue -> inflammation of luns -> alveolar neutrophils and macrophages are activated to engulf mycobacterium -> macrophages build walls around mycobacterium -> stops spread -> process forms granulomatous lesions (tubercles) -> formation of lung tissue necrosis from dead infected tissues -> ~10 days: macrophage work complete and scar tissues formed -> immunity developed -> ASYMPTOMATIC
Term
pathophysiology of active TB
Definition
mycobacterium not sealed off by macrophage -> mycobacterium multiplication -> inflammation -> formation of necrotic lung tissue -> tubercles forms and spread throughout lung -> can spread and affect glands, bones, meninges and kidneys
Term
list at least 2 diagnostic test for TB
Definition
mantoux test, chest x-ray, x3 positve sputum cultures, blood test showing interfon gamma (immune response to TB)
Term
list at least 5 clinical manifestations of active TB
Definition
cough persistent for at least 3 weeks, chest pain, haemoptysis (coughing up of blood), fatigue, weight loss, poor appetite, chills, fever, sweat at night
Term
infectious vs non-infectious TB
Definition
latent: not infectious
active: infectious
Term
haemoptysis
Definition
coughing up of blood
Term
name at least 3 drugs for tuberculosis treatment
Definition
anti-tubercular drugs:
isoniazid
rifampin
pyrazinamide
ethambutol
streptomycin
capreomycin
Term
define restrictive pulmonary disorders
Definition
lung tissue ability to stretch is reduced that restricts breathing
Term
factors inside lungs causing restrictive pulmonary disorders
Definition
fibosis (scarring), inflammation
Term
factors outside lungs causing restrictive pulmonary disorders
Definition
pain from pleurisy or injury
Term
pleurisy
Definition
inflammation of the pleura (membrane surrounding the lungs)
Term
define emphysema
Definition
reduced surface area of lungs caused by rupture or other damage to alveoli. There is an abnormal enlargement of the gas exchange airways and loss of elastic recoil. Accompanied by alveolar wall destruction
Term
define asthma
Definition
spasms of the airways + oedema and increased mucus production
Term
define chronic bronchitis
Definition
chronic inflammation of the bronchioles
Term
4 types of obstructive pulmonary disorders
Definition
chronic obstructive pulmonary disease (COPD)
chronic bronchitis
emphysema
asthma
Term
substances that may cause occlusion of the pulmonary vascular bed (5)
Definition
thrombus, embolus, tissue fragment, lipids or an air bubble
Term
most common area that a pulmonary emboli may arise from
Definition
deep veins in the legs and pelvis
Term
venostasis
Definition
slow blood flow from veins
Term
biological predisposing factors contributing to thrombus and occlusion of embolus (3)
Definition
venous stasis, hyper coagulability and injuries to endothelial cells lining the blood vessels
Term
thrombus
Definition
blood clot that is formed and remains in the blood vessels (http://www.umassmed.edu/strokestop/module_one/thrombus_embolus.html)
Term
embolus
Definition
large particle in the bloodstream that will eventually occlude a narrower lumen of the blood vessels. May an air air bubble, lipids, bits of plaque and is most often a thrombus (http://www.umassmed.edu/strokestop/module_one/thrombus_embolus.html)
Term
list at least 5 clinical manifestations of pulmonary embolism
Definition
dyspneoa, tachypneoea, chest pain, shock, systemic hypotension, decreased CO, decreased PaO2, pulmonary infarction, increased dead space
Term
Define and describe cor pulmonae
Definition
a pulmonary heart disease. Right ventricular enlargement.
Term
describe how for pulmonae is secondary to another condition
Definition
Secondary to pulmonary hypertension as it creates chronic pressure overload in the right ventricle
Term
pulmonary oedema
Definition
excess water in lungs
Term
hypoxaemia
Definition
ventilation/ perfusion difficulties
Term
hypoxia
Definition
low O2
Term
bronchiectasis
Definition
abnormally persistant dilation of bronchi
Term
pneumothorax
Definition
air or gas leaked into the pleural space
Term
atelectasis
Definition
partial or complete collapse of lungs. Alveoli become deflated
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