Term
What TH1 cytokine interleukin is crucial for combating endogenous antigens (intracellular infections, cancer)? |
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Definition
IL-2 is crucial for what? |
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Term
Name the three primary Th cells? What are naive Th cells called? |
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Definition
What are Th1, Th2, Th17
What does Th0
indicated?
(good kitty. why are you hiding under Ryan's couch?)
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Term
What interleukins do TH2 cells have?
(come on, now! Imagine it's trivia night!) |
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Definition
IL-4 (B cells), IL-5 (eosinophils), and IL-8 (neutrophils) |
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Term
| What are TH2 cells crucial for? |
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Definition
What is crucial for
combating extracellular antigen via the generation of antibodies (humoral immunity), chemotaxis of eosinophils and PMNs and allergies? |
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Term
What does IL17 do? Which cell produces it?
(I hate to quote Homer Simpson, so I'll say "duh" and expect that we'll win the Nobel prize for naming it)
How about IL-22? Which cell produces this one?
(doh!) |
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Definition
Th17 produces both.
IL-17 which stimulates macrophages and other inflammatory cells to migrate to the area of injury;
IL-22 which stimulate epithelial cells to secrete antimicrobial chemicals. |
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Term
What inhibits Th2 activity?
How about Th1 activity? |
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Definition
Shouldn't have been such a "rockstar", huh?
These questions are too easy.
IFN g inhibits TH2 activity;
IL-4 inhibits TH1 activity |
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Term
What kind of cells are T regulatory cells?
How are they referred to?
(come on out, kitty; it's Tuesday; Ryan's at trivia) |
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Definition
Some CD4 cells are called T regulatory cells. They produce IL-10 and TGFb which suppress T cell activity.
This has been called the Th3 cytokine profile
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Term
Name the 4 interleukins Th2 makes? |
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Definition
Il4: B cells
IL5: eosionsophils (allergies)
Il8 neutrophils:
IL 13: epith cells and smooth muscles
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Term
Name some key effector cells? |
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Definition
macrophages, T cytotoxic cells, B cells, PMN's and Eosinophils |
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Term
Where are granzymes founds? And what do they do?
(imagine Tina on test day saying "duh") |
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Definition
granzymes include proteases, perforins and phospholipases that are toxic to the target cell and can directly kill the cell with release of cellular antigens (may become exogenous antigens for CD4 activation)
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Term
To really fight cancer or HIV what is given? |
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Definition
give IL2 to really kick in and then interferon--
to stimulate ability to kill cells infected or w/ cancer
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Term
In a Th1 cells, what does Interferon act upon?
in a Th1 cell, what does IL2 act upon? |
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Definition
Interferon---macrophages
IL2--T-cytotoxic cells |
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Term
What another name for a Th 8 cell?
How 'bout a Th 4 cell? |
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Definition
T cytotoxic cell
T helper cell
(you got it now. no need to study more. You got it!) |
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Term
What iL's does a Th2 cell make?
What what does each one of these act upon? |
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Definition
IL-4, IL-5 and IL-8
IL-4>>>>B cells
IL-5 >>> Eosinophils
IL-8>>>PMNs
(good job! your preceptor will be so proud. don't worry that you forgot to check vitals and put the suppository in with the wrapper intact. At least you remembered to take a lunch break)
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Term
This one is a little trickier.
What should our group name be at trivia night? |
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Definition
Come on, Matty! That's been used over 30 times. Enough with the Depends jokes, and may Patrick Swayze finally rest in peace. |
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Term
What creates IL-17 and IL-22?
Which cell type does IL-17 act upon?
IL-22? |
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Definition
Thelper 17 cell
(I know; these are too easy)
IL-17 acts on Macs
IL-22 epithelial cells |
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Term
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Definition
made from T-helper 1 cytokines
(N1ke? does that help?) |
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Term
do NK cells use MHC or activate CD4? |
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Definition
Nope, not at all.
- uses its own NK receptor to bind to transformed cells (especially tumor cells) without using the MHC complex
(MHC unrestricted) or the activation of CD4 cells then kills with toxins
(doh!)
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