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Pathology Unit V
Female Reproductive System: Female Genital Infections: Sexually-Transmitted Infections
36
Pathology
Graduate
03/06/2013

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Term
Trichomonas vaginalis definition
Definition
protozoal infection of the vagina/cervix = Trichomoniassis
Term
most common manifestations of Trichomonas vaginalis
Definition
discharge, pruritus, strawberry cervix
Term
characteristic method of dx of Trichomonas vaginalis
Definition
wet mounts, pap smear
Term
important clinical consequences of Trichomonas vaginalis
Definition
Term
Candida albicans definition
Definition
fungal infection of vagina/cervix = candidiasis
Term
most common manifestations of Candida albicans
Definition
yeast infection
Term
characteristic method of dx of Candida albicans
Definition
wet mounts demonstrating spores and pseudohyphae and pap smear
Term
important clinical consequences of Candida albicans
Definition
leukorrhea and pruritus. Common in women with diabetes mellitus, on oral contraceptives, pregnant, 40% mortality and morbidity in low birth-weight infants, affects 75% of women
Term
Gardnerella vaginalis definition
Definition
gram-negative, small bacillus thought to cause vaginitis/cervicitis = Gardnerella Infection
Term
most common manifestations of Gardnerella vaginalis
Definition
clue cells
Term
characteristic methods of dx of Gardnerella vaginalis
Definition
producing transient “fishy odor” when exposed to 10% potassium hydroxide (KOH whiff test)
Term
important clinical consequences of Gardnerella vaginalis
Definition
burning, itching, white or gray, malodorous vaginal discharge with a pH 5.0 to 5.5
Term
Herpes simplex virus definition
Definition
viral infection producing ulcerative lesions of vulva, vagina, cervix = Herpes genitalis
Term
most common manifestations of Herpes simplex virus
Definition
: multinucleated GC
Term
characteristic methods of dx of Herpes simplex virus
Definition
cytologic smear, culture and immunologic methods
Term
important clinical consequences of Herpes simplex virus
Definition
most important to avoid transmission during childbirth; may be a co-carcinogen.
Term
Chlamydia trachomatis definition
Definition
Ricketsiae infection that commonly causes cervicitis (chronic follicular) but may ascend to uterus, fallopian tubes, resulting in endometritis and salpingitis (PID).
Term
most common manifestations of Chlamydia trachomatis
Definition
C. trachomatis is a leading cause of preventable blindness (D-K), Lymphogranuloma venereum - venerally transmitted disease caused by the L-1, L-2, of L-3 serotype of C. trachomatis. Involves regional lymph nodes with production of buboes (abscesses), leading to continued inflammation and scarring - rectal stenosis or chronic genital lymphedema (L1-L3)
Term
characteristic methods of dx of Chlamydia trachomatis
Definition
culture, immunofluorescence (D-K), - histologic examination, tissue culture (L1-L3)
Term
important clinical consequences of Chlamydia trachomatis
Definition
chronic cervicitis, PID (D-K)
Term
Actinomyces israelii definition
Definition
: gram--positive, non-acid-fast, anaerobic bacteria that is associated with use of intrauterine contraceptive devices and other foreign bodies in the female genital tract
Term
most common manifestations of Actinomyces israelii
Definition
Bacterium associated with long term irritation by foreign bodies, such as IUDs. tampons, pessaries. Often commensal but does have ability to become invasive, cause pelvic actinomycosis
Term
characteristic methods of dx of Actinomyces israelii
Definition
sulfur granules in culture
Term
important clinical consequences of Actinomyces israelii
Definition
May affect uterine cervix, fallopian tubes, ovary, and associated pelvic organs.
Term
Neisseria gonorrhoeae definition
Definition
pyogenic gram-negative diplococci - cause of Gonorrhea
Term
most common manifestations of Neisseria gonorrhoeae
Definition
infection often produces pelvic inflammatory disease (PID
Term
characteristic methods of dx of Neisseria gonorrhoeae
Definition
culture, gram stain shows diplococci in cytoplasm of neutrophils
Term
important clinical consequences of Neisseria gonorrhoeae
Definition
: bilateral tubo-ovarian abscesses, salpingo-oophoritis, pyosalpinx, hydrosalpinx, peritonitis, intestinal obstruction due to adhesions between the small bowel and the pelvic organs, bacteremia, infertility.
Term
Treponema pallidum defintion
Definition
spirochete - cause of syphilis
Term
most common manifestations of Treponema pallidum
Definition
chancre (painless)
Term
characteristic methods of dx of Treponema pallidum
Definition
: silver impregnation, dark-field examination, or immunofluorescent techniques.
Term
important clinical consequences of Treponema pallidum
Definition
: chancre (on vulva or cervix), rash (generalized), papular lesions (condyloma lata, vulva), involvement of cardiovascular system, central nervous system, liver and other organs. Congenital - late abortion, stillbirth, or perinatal death, infection of lungs, CNS, eye, etc
Term
Human papillomavirus (HPV) definition
Definition
virus that causes Condyloma acuminatum - genital warts
Term
most common manifestations of Human papillomavirus (HPV
Definition
Cyto/histo feature – koilocytes
Term
characteristic methods of dx of Human papillomavirus (HPV
Definition
culture
Term
important clinical consequences of Human papillomavirus (HPV
Definition
May occur in vulva, cervix Viral types 6 and 11 are associated with simple warts. Types 16, 18, 33 are associated with cervical carcinoma.
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