Term
| Epidermal Growth Factor (EGF) |
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Definition
-produced by keratinocytes, macrophages, and other inflammatory cells
-stimulate proliferation of epithelial cells, hepatocytes, and fibroblasts
-keratinocyte migration, granulation tissue formation |
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Term
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Definition
-involved in epithelial cell proliferation in embryos and adults
-involved in malignant transformation of normal cells to cancer |
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Term
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Definition
-produced by fibroblasts, endothelial cells, non-parenchymal liver cells
-stimulates proliferation of epithelial cells
-promotes cell migration in embryonic development |
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Term
| Platelet Derived Growth Factor (PDGF) |
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Definition
-stored in platelet alpha granules
-also produced by many other cells
-causes migration and proliferation of fibroblasts, SMOOTH MUSCLE CELLS, monocytes |
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Term
| Vascular endothelial Growth factor (VEGF) |
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Definition
vasculogenesis
angiogenesis |
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Term
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Definition
stimulation of angiogenesis
-migration of macrophages, fibroblasts and endothelium
migration of epithelium for new epidermis
skeletal muscle development and lung maturation
differentiation of specific blood lineages |
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Term
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Definition
inhibits growth of epithelial cells and leukocytes by blocking the cell cycle through increased expression of cell cycle inhibitors
-stimulates production of fibroblasts and smooth muscle cells
-stimulates fibroblast chemotaxis
-strong anti-inflmmatory effect
-involved in development of fibrosis
-production of ECM proteins
-most important fibrogenic agent |
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Term
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Definition
| recruits periendothelial cells |
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