Term
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Definition
-stimulates redistribution of P-selectin to the cell surface
-found predominantly in mast cells
-fragments of compliment can cause its release
-dilation of arterioles, increased permeability of venules
-principal mediator of the immediate transient phase |
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Term
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Definition
-major macrophage activating cytokine
-produced by activated T cells and NK cells |
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Term
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Definition
-stimulate release of histamine
-transmission of pain signals
-increase vascular permeability |
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Term
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Definition
-found mainly in platelets, released from platelts when platelets aggregate
-aid in coagulation |
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Term
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Definition
cause vasoconstriction
promotes platelet aggregation |
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Term
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Definition
| produced by vascular endothelium, causes vasodilation and inhibits platelet aggregation |
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Term
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Definition
| hyperalgesic and involved in cytokine-induced fever |
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Term
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Definition
major metabolite of cyclooxygenase in mast cells
vasodilation
increases permeability in venules and potentiates edema |
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Term
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Definition
| chemotaxis and stimulation of neutrophils |
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Term
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Definition
intense vasoconstriction
bronchospasm
increased vascular permeability
(lipoxygenase pathway) |
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Term
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Definition
| inhibit leukocyte recruitment and cellular components of inflammation |
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Term
| Platelet Activating Factor |
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Definition
comes in a variety of different cell types
platelet stimulation
vasoconstriction and bronchoconstriction
-at very low concentrations aids in inflammation process |
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Term
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Definition
VASODILATOR
reduces platelet aggregation and adhesion
reduces leukocyte recruitment
inhibits mas cell induced inflammation
limit replication of many microorganisms |
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Term
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Definition
-suppresses appetite, promotes lipid and protein mobilization
-regulates the effects of septic shock |
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Term
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Definition
| chemotaxis and WBC adhesion |
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Term
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Definition
produced when kallikrein (from activated Hageman) cleaves HMWK
increased vascular permeability
contraction of smooth muscle
dilation of blood vessels
pain when injected into the skin |
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Term
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Definition
converts HMWK to bradykinin
converts plasminogen into plasmin |
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Term
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Definition
| kinin system, clotting system, firinolytic system (produces plasmin through kallikrein activation) and produces anaphylotoxins C3a and C5a |
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Term
| What is the hallmark of chronic inflammation? |
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Definition
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Term
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Definition
| terminally differentiated B cells |
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Term
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Definition
within the granules of eosinophils
toxic to parasites
causes lysis of host epithelial cells (cause of tissue damage) |
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Term
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Definition
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