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Pathology Exam 1 Lecture 9
Cerebrovascular Accident
81
Pathology
Graduate
07/20/2016

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Term
Ischemic CVA
-stats
-Types
Definition
-85% of CVA's
Types:
-Thrombus: clot within the cerebral arteries
-Embolus: traveling matter that occlude cerebral arteries
Term
Hemmorrhagic CVA
-stats
-what is it?
-Types?
Definition
-15% of CVA's, 40% of whom die
-Abnormal bleeding as a result of ruptured vessel
Types:
-SubArachnoid hemmorhage
-SubDural Hemmorhage
-Arteriovenous malformations
Term
Thrombotic CVA
progression
Definition
1. Atherosclerosis
-Plaque deposits
-decreases lumen
2. Blood flow
-Reduces, thus reducing oxygen to tissues
3. Cerebral infarction
-complete occlusion causes cell death
Term
Embolic CVA
progression
Definition
1. Embolus
-Atrial fibrillation, Myocardial infarction, valvular disease
-clot breaks away
2. Occlusion
-Clot lodges in a cerebral blood vessel
3. Cerebral infarction
-Perfusion <8-10mL/100mg, cell death occurs
Term
ischemic penumbra
Definition
tissue surrounding the irreversible ischemia of a thrombotic or embolic stroke, where ischemia can be reversed and cells recovered.
-Blood flow is 20-50% of norm,
Term
transient ischemic event
Definition
-temporary interruption of blood supply
-impairments resolve within 24 hours
-Recurring increases likelihood of CVA
Term
Diagnosis techniques for CVA
Definition
-determine etiology
-physical exam
-neuroimaging
Term
Acute medical management for CVA
Definition
-monitor neuro function
-prevent secondary complication
-regulate blood pressure, cerebral perfusion, and Intracranial pressure.
-pharmacology
-surgical intervention
Term
CVA recovery
Definition
-most significant within first 3 months
-impairment often persists
-15% die shortly after incident
Term
CVA risk factors
Definition
-hypertension
-cardiac disease
-diabetes mellitus
-smoking
-ETOH/drug use
-History of CVA/TIA
-Atrial Fibrillation
-inactivity
-obesity
-age >55years
-gender-male
-Race (AfricanAmer,Pac.Islanders, Hispan.)
Term
Hemispheric effects of CVA
-Visual perceptual
Definition
Right: left neglect, agnosias, difficulty processing visual cues

Left: Broca’s, Wernicke’s or global aphasia, difficulty processing verbal cues
Term
Hemispheric effects of CVA
-Behavioral
Definition
Right:Quick, impulsive, poor judgment, poor insight into deficits

Left: Slow, cautious, disorganized
Term
Hemispheric effects of CVA
-Intellectual
Definition
Right: Difficulty with abstract, rigidity of thought, difficulty with ‘whole idea’ of task

Left: Highly distractible, perseveration, difficulty initiating
Term
Hemispheric effects of CVA
-Emotional
Definition
Right: Difficulty perceiving emotions & expressing negative emotions

Left: Difficulty expressing positive emotions
Term
Hemispheric effects of CVA
-Task performance
Definition
Right: Fluctuations in performance

Left: Ideational/ideomotor apraxia
Term
incidence and cost of spinal cord injury
Definition
12,000 per year
~30-40/million annually
$2.2-4.6 mill
Term
most susceptible to Spinal cord injury
Definition
highly active persons
-16-30 years
-males account for 81% of all cases
Term
Syringomyelia
Definition
a chronic progressive disease in which longitudinal cavities form in the cervical region of the spinal cord.
-results in wasting of the muscles in the hands and a loss of sensation.
Term
SPinal cord contusion
Definition
-primary area damaged by hemmorhage, blood vessels cause necrosis
-Secondary injury from apoptosis, macrophages acting as immune mediators, and microglia damaging oligodendrocytes.
-Spared rim may allow preservatiton of function
Term
Mechanism for injury of spinal cord
Definition
-50% from excessive spinal flexion
-Concussion
-Contusion: glial tissue and cord intact
-Laceration:glia disrupted,cord maybe torn
-complete transection
Term
tetraplegia
Definition
aka quadriplegia, paralysis of 4 limbs
Term
paraplegia
Definition
paresis of the lower extremities and lower trunk
Term
incomplete spinal injury
Definition
-partial preservation of motor function/sensory below level of injury extending to S4-5
-Sacral sparring: anal sensation a voluntary contraction of anal sphincter
Term
Complete spinal injury
Definition
no sensory or motor function preserved in the segment s4-5
Term
Identifying the Level and extent of spinal injury
-naming
Definition
precisely document sensation in the dermatome and muscle strength in the myotome.
-named by the last intact neurological level
Term
SCI classification according to the asia impairment scale
Definition
A.Complete: no sensory or motor
B.Incomplete: sensory only
C.Incomplete: motor preserved below neurological level, more than half of the key muscles have a muscle grade <3to5
D. Incomplete: motor preserved below neurological level, more than half of the key muscles have a muscle grade >3to5
E. Normal
Term
CLinical manifestation of spinal cord injury
-skeletal
Definition
Heterotopic ossification
scoliosis
Term
CLinical manifestation of spinal cord injury
-pain
Definition
-Nerve root injury along with spinal cord damage
-Musculoskeletal pain especially from overworking muscles
Term
CLinical manifestation of spinal cord injury
-Cerebrovascular
Definition
-Autonomic nervous system dysfunction
-increased risk of deep venous thrombosis
Term
CLinical manifestation of spinal cord injury
-Respiratory
Definition
-High cervical lesions may lose independent breathing
-pneumonia - aspiration common cause of death
Term
CLinical manifestation of spinal cord injury
-Metabolic
Definition
-Osteoporosis
-Insulin resistance
-Increase in body fat
Term
CLinical manifestation of spinal cord injury
-bowel and bladder
Definition
-Normal reflexes may be absent
-Neurogenic Bladder
-UTI
Term
SPinal cord injury
-muscle tone
Definition
-flaccidity
-Autonomic symptoms (sweating, reflex incontinence)
-spasticity, all kinds
-Eventual atrophy of muscle
Term
Autonomic Dysreflexia
-what causes it
-symptoms
-immediate response/what to do
Definition
-occurs with spinal cord injury above T6
-Frequently will occur with an overextended bladder
-sympathetic response
-elevated BP >20mm Hg
-headache
Respond:
-remove noxious stimuli
-elevate head
Term
Pressure ulcers
-areas affected from supine position
Definition
-occiput
-scapulae
-vertebrae
-elbows
-sacrum
-coccyx
-heels
Term
pressure ulcers
-areas affected from prone position
Definition
-ears (head rotated)
-anterior shoulders
-iliac crest
-male genitalia
-patela
-dorsum of feet
Term
pressure ulcers
-areas affected from side-lying
Definition
-ears
-shoulders
-greater trochanter
-head of fibula
-knees (medial aspect from k-k contact)
-lateral malleolus
-medial malleolus
Term
Autonomic Dysreflexia
-what causes it
-symptoms
-immediate response/what to do
Definition
-occurs with spinal cord injury above T6
-Frequently will occur with an overextended bladder
-sympathetic response
-elevated BP >20mm Hg
-headache
Respond:
-remove noxious stimuli
-elevate head
Term
Pressure ulcers
-areas affected from supine position
Definition
-occiput
-scapulae
-vertebrae
-elbows
-sacrum
-coccyx
-heels
Term
pressure ulcers
-areas affected from prone position
Definition
-ears (head rotated)
-anterior shoulders
-iliac crest
-male genitalia
-patela
-dorsum of feet
Term
pressure ulcers
-areas affected from side-lying
Definition
-ears
-shoulders
-greater trochanter
-head of fibula
-knees (medial aspect from k-k contact)
-lateral malleolus
-medial malleolus
Term
Autonomic Dysreflexia
-what causes it
-symptoms
-immediate response/what to do
Definition
-occurs with spinal cord injury above T6
-Frequently will occur with an overextended bladder
-sympathetic response
-elevated BP >20mm Hg
-headache
Respond:
-remove noxious stimuli
-elevate head
Term
Autonomic Dysreflexia
-what causes it
-symptoms
-immediate response/what to do
Definition
-occurs with spinal cord injury above T6
-Frequently will occur with an overextended bladder
-sympathetic response
-elevated BP >20mm Hg
-headache
Respond:
-remove noxious stimuli
-elevate head
Term
Autonomic Dysreflexia
-what causes it
-symptoms
-immediate response/what to do
Definition
-occurs with spinal cord injury above T6
-Frequently will occur with an overextended bladder
-sympathetic response
-elevated BP >20mm Hg
-headache
Respond:
-remove noxious stimuli
-elevate head
Term
pressure ulcers
areas of concern when supine
Definition
-occiput
-scapulae
-vertebrae
-elbows
-sacrum
-coccyx
-heels
Term
pressure ulcers
areas of concern when prone
Definition
-ears (head rotated)
-anterior shoulders
-iliac crest
-male genitalia
-patela
-dorsum of feet
Term
pressure ulcers
areas of concern when side lying
Definition
-ears
-lateral shoulders
-greater trochanter
-head of fibula
-medial knees from knee-knee contact
-lateral maleolus
-medial maleolus from mal.-mal. contact
Term
Autonomic dysreflexia
-male sexual dysfunction
Definition
-depends on the level of injury
>High level lesions: reflexive erections but no ejaculate
>low level lesion: ejaculate but difficult erection
Term
Autonomic dysreflexia
-female reproductive organ dysfunction
Definition
-women may lose menses for 3-6 months
-pregnancy possible, but should be closely monitored for 2 loss of sensation
Term
autonomic dyreflexia
-sleep disorder
Definition
sleep apnea
Term
Autonomic dysreflexia
medical treatment
Definition
-spine stabilized via bracing
-medically induced hypothermia
-vital systems stabilized
-Surgical: internal spine fixation
-Pharmacological: control edema, blood flow & secondary neurologic sequalae, and corticosteroids
Term
Autonomic dysreflexia
-spasticity management
Definition
Baclofen
Functional electrical stimulation
Term
Autonomic dysreflexia
-Pain management
Definition
-meds
-Transcutaneous Electrical Nerve Stimulation
Term
Traumatic brain injury - cause
Definition
-caused by external physical force, contact or rotational
Term
Traumatic brain injury
Definition
2.2mill per year
male:female - 2:1
ages: 1-2y, 15-24y, >75y
Term
Types of traumatic brain injury
Definition
Open or closed
Term
OPEN TBI
Definition
OPEN
-skull fracture of displacement
-torn meninges
-brain exposure
-risk infection
Term
CLOSED TBI
Definition
-No skull fx
-Neural tissue damaged
-Dura remains intact
-Risk of ICP
Term
Traumatic brain injury, subtypes
Definition
Concussion
Contusion
Hematomas
Locked-In syndrome
Acquired brain injuries
Sudden impact syndrome
Term
Epidural Hematoma
Definition
blood fills space between dura and skull
LOC followed by A&O
Rapid deterioration
Term
Subdural hematoma
Definition
S/S fluctuate and resemble CVA
↓ LOC
Contralateral HP
Ipsilateral pupil dilation
Term
locked in syndrome
Definition
Complete paralysis of voluntary muscles except eyes
Cognition intact
Term
Acquired Brain Injuries
Definition
Not hereditary, congenital, degenerative, or birth trauma
Airway obstruction, near drowning, MI…
Term
medical management of TBI
Definition
Decompression of skull
Hemorrhage/hematoma evacuation
Intubation
Chest tubes
IVs, swan ganz catheter, epidural sensor
Term
primary damage with TBI
Definition
Damage at site of impact
Coup-Contrecoup injury
Diffuse axonal injury
Laceration to cerebral tissue
Term
Secondary damage with TBI
Definition
Changes due to brains rxn to trauma
-ICP
-Anoxic injuries
-Seizures
Term
Diffuse Axonal Injury
Definition
Disruption & tearing of axons and small vessels from shear-strain of angular acceleration

Neuronal death and petechial hemorrhages

High velocity & rotational injuries
Term
anoxia
& the brain
Definition
an absence or deficiency of oxygen reaching the tissues.
-Brain demands 20% of O2,
Term
seizure triggers
Definition
Vestibular stimulation
Stress
Poor nutrition
Electrolyte imbalance
Drug use
Missed meds
Infection
Term
Intracranial pressure description
Definition
Present in 70% of TBI cases
Normal ICP (0-15mm Hg)
Compression of brain tissue
↓ perfusion
Herniation
Term
increased intracranial pressure, signs and symptoms
Definition
↓ responsiveness
Impaired consciousness
Severe HA
Vomiting
Irritability
Papilledema
↑ BP, ↓ HR
Term
Problem areas with TBI
Definition
↓ level of arousal
Cognitive impairments
Motor disorders
Sensory problems
Communication deficits
Behavioral changes
Associated problems
Term
Glasgow Coma Scale
Definition
can be used to assess outcome of TBI
terms include:
Arousal: state of being awake
Awareness: conscious to internal & external stimuli
Consciousness: state of being aware
Stupor: general unresponsiveness
Obtundity: sleep lot, disinterested, slow to respond
Delirium: disorientation, fear, misperception of sensory stimulus
Term
Rancho Los Amigos LOCFRancho Los Amigos LOCF
Definition
can be used to assess outcome of TBI
terms include:
Disorientation
Poor attention span
Loss of memory
Loss of executive functions (planning & organizational skills, recognizing errors, problem solving, abstract thinking)
Inability to control emotional responses
Term
MOTOR DEFICITS associated with TBI
Definition
Abnormal postures
Decerebrate: severing of midbrain
Decorticate: dysfunction between basal nuclei & thalamus
Weakness
Initiation difficulty
Tonal abnormalities
Primitive & tonic reflex reemergence
Sequencing
Ataxia
Gait impairments
Balance impairments
Term
Decerebrate Rigidity
Definition
-hips adducted and internally rotated
-knees extended
-ankles plantar flexed
-feet supinated
-UE internally rotated, extended at shoulders and elbows, pronated forearms, flexed wrists and fingers
Term
Decorticate Rigidity
Definition
-hips adducted and internally rotated
-knees extended
-ankles plantar flexed
-feet supinated
UE: flexion with adduction and internal rotation of the shoulders, flexion of the elbows, pronation of the forearms, flexion of the wrists, and extension of the lower extremities
Term
Sensory Deficits
with TBI
Definition
Tactile & kinesthetic sensations
Visual, perceptual & proprioceptive deficits
Term
Communication Deficits
with TBI
Definition
Initiation of speech
Inappropriate speech
Receptive
Term
Behavioral Deficits
with TBI
Definition
Neuroses
Psychoses
Sexual disinhibition
Apathy
Irritability
Lability
Aggression
Low frustration tolerance
Term
associated problems with TBI
Definition
-heterotopic ossification
-myositis ossification
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