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Pathology Exam 1 lecture 5
Infectious disease
57
Physiology
Graduate
07/13/2016

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Term
outward signs of infection
Definition
-fever, chills, malaise
-enlarged lymph nodes (axillary, cervical, inguinal)
Term
integument signs of infection
Definition
drainage, rash, streaks
Term
cardiovascular signs of infection
Definition
tachycardia, hypotension
Term
central nervous system signs of infection
Definition
altered consciousness, confusion, convulsions, HA, photophobia, muscle aches
Term
Gastro intestinal signs of infection
Definition
nausea, vomiting, diarrhea
Term
genitourinary signs of infection
Definition
dysuria, hematuria, urgency, frequency
Term
respiratory signs of infection
Definition
tachypnea, cough, hoarseness, drainage, over-production, diminished exercise tolerance
Term
joint infection signs
Definition
effusion (increased intra-articular fluid.)
Term
fever temperatures and treatments
Definition
104: delerium, seizures
107.6: cell damage
-drugs reduce fever (acetaminophen)
-cool off with water or ice
Term
risks for infection associated with aging
Definition
-decreased # of T cells
-diminished cell-mediated immunity:dormant viruses reactivate
- changes in CV, resp, nutrition
- physical and mental disability
- impaired thermoregulation
- skin thinning
- drug intake could mask fever
Term
pathogen
Definition
any microorganism that has the capacity to cause disease
Term
things a pathogen may do
Definition
1. contaminate body surface and be destroyed by first-line defenses
2.subclinical infection - no symptoms other than identfiable immune response.
3. clinically apparent infection - causes obvious damage and is accompanied by clinical symptoms (infectious disease)
Term
communicability period
Definition
when an organism can be passed on to another person or organism
Term
incubation period
Definition
time between pathogen entering the host and appearance of symptoms
Term
virus classification
Definition
-size
-shape (spherical, rod shaped, cubic)
-means of transmission (resp., fecal, oral, sex.)
Term
bacteria
Definition
-single celled
-cell walls
-grow independently
Term
bacteria classification
Definition
according to
-response to staining (Gr+, Gr-, AcidFast)
-motility
-capsulation
-non/spore forming
Term
principle pathogens
Definition
cause disease in people with apparently intact immune system
Term
opportunistic pathogens
Definition
no disease in healthy people, but cause disease in the immunocompromised
Term
pathogenicity
-define
-influencing factors
Definition
-the ability of an organism to induce disease
depends on
-organism's speed of reproduction
-extent of damage on tissues
-strength of any toxins released
Term
virulence
-define
-how measured?
Definition
the potency of a pathogen in producing severe disease
-measured by fatality rate
Term
Transmission train components
Definition
-characteristics of pathogen
-portal of entry
- reservoir (humans, animals, environmental)
-portal of exit (resp.tract, GI, blood..)
-mode of transmission
-characteristics of the host
Term
components in controlling disease transmission
Definition
1. lines of defense (barrier, inflammatory, immune response)
2. PPE and hand washing
3. drug prophylaxis
4. nutrition
5. living conditions
Term
5 main routes of transmission
Definition
1. contact
2. airborne
3. droplet
4. vehicle
5. vector borne
Term
contact transmission
-define
Definition
-direct: skin-skin, mucousal mem.-mucousal mem.
-indirect: via an inanimate intermediate object
Term
contact transmission
-precautions
Definition
-private room
-gloves
-gown
-disinfect equipment
-use infectious waste cans
Term
bloodborne transmission precautions
Definition
everyone assumed to have something
Term
airborne transmission
-define
-precautions
Definition
-pathogen oragnisms are less than 5 microns, and can float on air currents
precautions
-monitored negative air flow
- private room
- door closed
- restrict entry
- limit transport from room
Term
droplet transmission
-define
-precautions
Definition
-pathogen organism travels in droplets, larger than 5 microns, so can only travel within 3 feet of host
----precautions----
-3 feet vulnerability
-open door ok
- mask w/in 3 feet
- have patient wear mask
Term
vehicle transmission
Definition
food source, water source
Term
vector-borne transmission
Definition
involves insects or animals that act as intermediaries between 2 or more hosts
Term
nosocomial infections
Definition
-acquired during hospitalization
-5% of disease in USA
-there are facility procedures and CDC guidelines
Term
clostridium difficile
Definition
-associated with antibiotic use
-transmission - fecal-oral
-presents as diarrhea and increased WBC
-diagnosed identifying toxin in stool
-individual taken off antibiotics
-prevent with contact precautions and private rooms
Term
staphylococcal bacteria
-general
Definition
-leading cause of nosocomial and community acquired infections - 13% of hospital infections
-common on skin
Term
staphylococcal bacteria
-transmission
-presentation
-treatment
Definition
Transmission
-direct contact, cannot infect through intact skin or mucous membranes
Presentation
-abcess, chills, fever, redness, increase WBC
-systemic symptoms
Treatment
-Antibiotics
-Methicillin, Vancomysin
Term
Streptococcal pyogenes
-transmission and forms
Definition
-transmission by droplet or direct contact
2 forms
-Suppurative (forms pus)
-nonsuppurative (doesn't form pus)
Term
Streptococcal pyogens
-presentation
-treatment
Definition
presentation:
-fever
-sore throat w/ swallowing pain
-beefy red pharynx
-edematous tonsils w/ exudate
-swollen lymph nodes along jaw line
-malaise
-anorexia, abdominal discomfort
TREAT WITH ANTIBIOTICS
Term
Suppurative streptococcal pyogenes -characteristic -symptoms
Definition
forms pus -pharyngitis - throat -impetigo - skin -necrotizing faciitis
Term
nonsuppurative streptococcal pyogenes
-characteristic
-symptoms
Definition
doesn't form pus
-rheumatic fever
-glomerulonephritis
Term
pharyingitis
Definition
-caused by streptococcus pyogenes
-redness, swelling of throat, painful swallowing
-treated with antibiotics
Term
impetigo
Definition
-caused by streptococcus pyogenes
-occurs in children 2-5 years
-pustules on face
Term
necrotizing faciitis
Definition
-caused by streptococcus pyogenes
-infection progresses along fascial planes, often in the legs, causing severe tissue damage
Term
streptococcus pneumonia
-associated conditions
-colonization
-transmission
-clinical manifestation
-diagnosis
-treatment
Definition
-pneumonia, meningitis
-in the oropharynx
-transmits in droplets of resp. secretions or direct contact
-fever, chills, dyspnea, blood in sputum, rapid progression over 24-48h with high mortality rate w/o treatment
-diagnose by lab tests of sputum
-treat with antibiotic and vaccine
Term
pseudomonas
-general info
-colonization
-transmission
-diagnosis
-treatment
Definition
-opportunistic invader (hospital environments, wounds, UTI, sepsis)
-likes moist environments
-transmits by contact
-diagnosis by testing body fluid
-treatment: antibiotics, airway clearance, debridement if wound
Term
pseudomonas
how's contact made?
Definition
depends on where located
-resp. tract infection
-CNS via ear infection or invasive procedure
-in skin via burn or wound
-bone & joint via surgery or from skin
-
Term
pseudomonas
-clinical manifestation
Definition
-fever
-tachypnea
-tachycardia
-hypotension
-delerium
-dyspnea
-cough
-elevated WBC
-can spread to blood and metastasize
Term
viral treatment
Definition
acyclovir
Term
shingles
Definition
type 3 herpes, caused by varicella zoster
recurring chicken pox, with blister-like lesions along dermatomes from T3-L3
-can lead to nerve pain: postherpetic neualgia (PHN)
Term
mononucleosis
Definition
-Herpes IV
-incubates for 14-16 days
-can be contagious days before rash
-transmission via contact
Term
cold sores
Definition
virus
herpes simplex 1
70% have it
Term
genital herpes
Definition
viral
herpes simplex 2
20% have it
Term
cytomegalovirus
-aka
-% occurance
-transmission
-threat
-diagnosed
Definition
viral
Herpes type 5
80% of people over 35 have it
-transmitted via bodily fluids
-no symptoms in healthy individual, but deadly in transplants and unborn babies
-diagnosed via culture (blood, sputum, throat swab)
Term
influenza
-transmission
-symptoms
-prevention
-treatment
Definition
-transmission - aerosol & direct
-symptoms: abrupt fever, chills, malaise, muscle ache, headache, sore throat, nasal congestion, dry cough
-prevent: vaccine
-treat: runs course in 3-7 days, rest, symptom control meds
Term
avain flu
-mortality
-transfer
Definition
50% mortality
person-person is difficult, mostly bird-person
Term
Lyme disease
-type of bacteria
-transmission
-symptoms
-treatment
Definition
-spirochete bacteria
-passed on by tick saliva
-imitates other diseases with flu, fever, chills, headache, lethargy
leads to MENINGITIS
-treatment: look for bullseye rash, easily treated early with antibiotics
Term
lyme disease diagnosis
Definition
-test blood for spirochete antibodies
(with enzyme immunoassay, EIA or IFA)
-western immunoblot for confirmation
Term
HPV
Definition
-STI
-genital warts
-vaccine exists
-primary cause of cervical cancer
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