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Patho - Test 2 - Starred
starred class questions
35
Pathology
Graduate
03/18/2011

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Term
What are the three types of arteriosclerosis?
Definition
1) Atherosclerosis
2) Monckeberg's arteriosclerosis
3) Arteriolosclerosis
Term
What is arteriosclerosis?
Definition
thickening and loss of elasticity of the arterial walls (hardening of the arteries)
Term
What is atherosclerosis?
Definition
plaque and fatty build up in the intima (inner-most layer of the heart); creates turbulance with blood flow; increased BP
Term
Explain Monckeberg's arteriosclerosis.
Definition
destruction of mm and elastic fibers and formation of Ca deposits

occurs in the middle layer of the heart
Term
What is arteriolosclerosis?
Definition
thickening of the walls of small A (arterioles)
Term
Name the 3 types of angina.
Definition
1) chronic stable
2) unstable
3) Prinzmetal's or vasospastic angina
Term
Explain what chronic stable angina (aka _____) is.
Definition
aka exertional angina because occurs at a predictable level of activity or emotional stress

goal: to workout just below the threshold so you can build up endurance
Term
Describe unstable angina.
Definition
unpredictable, not related to usual demand for myocardial O2

symptom of disease progression
Term
What does Prinzmetal's or vasospastic angina result from?
Definition
due to coronary artery spasm and is likely to occur in the first few hours of rising
Term
What are the 3 zones of damage in an MI?
Definition
1) Zone of infarction
2) Zone of hypoxic injury
3) Zone of ischemia
Term
What is the Zone of infarction?
Definition
area of myocardium that was completely deprived of O2 resulting in cell death
Term
What is the zone of hypoxic injury?
Definition
immediately surrounding the area of infarction and will recover if blood flow is quickly restored
Term
The zone of _______ is usually reversible.
Definition
Zone of Ischemia
Term
What is the healing amount 18-24 hours post-MI?
Definition
anti-inflammatory response
Term
What is the healing amount 2-4 days post-MI?
Definition
visible necrosis, proteolytic enzymes remove debris
Term
What is the healing amount 4-10 days post-MI?
Definition
debris is cleared, collagen matrix laid down
Term
10-14 days post-MI?
Definition
a weak, fibrotic scar begins to be revascularized
Term
What is the healing amount 6 weeks post-MI?
Definition
a tough, inelastic scar is in place which can now tolerate heavy stress
Term
Name the fxns of the following MI medications:

1) B-blocker
2) nitroglycerine
3) Ca-channel blockers
4) diuretics
5) Aspirin
6) ACE inhibitors
Definition
1) B-blocker - increase workload on heart, decreases reoccurance of MI

2) nitroglycerine - vasodilate peripheral vessels

3) Ca-channel blockers - relax the arteries

4) diuretics - change blood conc and vol...

5) Aspirin - anticoagulent

6) ACE inhibitors - improve pump fxn (and?)
Term
What are the clinical manifestations of cardiomyopathy?
Definition
- generally same as heart failure
- dilated (fatigue or weakness w/normal or low BP)
- hypertonic (freq asymptomatic, sudden death is a presenting sign, dyspnea common)
- restrictive - decreased CO leading to high intraventricular P and signs of CHF
Term
What are the 3 ways Pulmonary diseases are classified by?
Definition
1) acute or chronic
2) obstructive or restrictive
3) infectious or non-infectious
Term
Name the 5 altered breathing patterns and sounds...
Definition
1) apneustic
2) Cheyne-Stokes
3) Lateral costal breathing
4) Stridor
5) Wheezing
Term
Define apneustic.
Definition
gasping inspiration followed by short expiration

like sleep apnea
Term
What is Cheyne-Stokes breathing?
Definition
seen at end of life, repeated cycles of deep breathing f/b shallow breaths or cessation of breathing

breathing is: deep --> shallow --> stops
Term
Explain lateral costal breathing.
Definition
can't expand chest;chest flattened ant. w/ flaring of lower ribs (supine); min up chest expansion or accessory mm involvement; person breaths into lateral plane due to diaphragm and intercostal mm weakness
Term
Define stridor.
Definition
shrill, harsh sound on inspiration
Term
What is wheezing?
Definition
breathing with rasp or whistle due to constriction or obstruction
Term
Describe the main differences between restrictive and obstructive diseases.
Definition
Term
Name the 4 diseases related to the bronchioles.
Definition
1) asthma
2) chronic bronchitis
3) FINISH?
Term
What are the 3 classifications of cardiomyopathies?
Definition
1) dilated
2) hypertrophic
3) restrictive
Term
Define "dilated cardiomyopathy."
Definition
fatigue and weakness with normal or low BP
Term
Define "hypertrophic cardiomyopathy."
Definition
frequent asymptomatic with sudden death being a presenting sign, dyspnea is common
Term
What is restrictive cardiomyopathy?
Definition
decrease CO leading to high intraventricular P and signs of CHF
Term
What is Mitral Valve Prolapse (MVP)?
Definition
variation in shape/structure of the mitral valve, causing one or both of the mitral valve leaflets to billow or bulge backward into the L atrium during LV contraction
Term
List some of the symptoms of MVP.
Definition
- irregular heart beat
- tachycardia
- fatigue and weakness
- panic attack or anxiety
- sleeplessness, dizziness, migraines
- intestinal problems
- mitral click or murmur
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